SG11201408194SA - Method for producing haemophilus influenzae type b antigens - Google Patents
Method for producing haemophilus influenzae type b antigensInfo
- Publication number
- SG11201408194SA SG11201408194SA SG11201408194SA SG11201408194SA SG11201408194SA SG 11201408194S A SG11201408194S A SG 11201408194SA SG 11201408194S A SG11201408194S A SG 11201408194SA SG 11201408194S A SG11201408194S A SG 11201408194SA SG 11201408194S A SG11201408194S A SG 11201408194SA
- Authority
- SG
- Singapore
- Prior art keywords
- culture
- des
- internationale
- influenzae type
- pour
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
(12) DEMANDE INTERNATIONALE PUBLIEE EN VERTU DU TRAITE DE COOPERATION EN MATIERE DE BREVETS (PCT) (19) Organisation Mondiale de la Propriete Intellectuelle Bureau international —- (I®) Numero de publication internationale (43) Date de la publication internationale ^ _ WO 2014/006318 A1 9 janvier 2014 (09.01.2014) WIPO I PCT (51) Classification internationale des brevets : C12N1/20 (2006.01) A61K 47/26 (2006.01) A61K39/102 ( 2006.01) (21) Numero de la demande internationale : PCT/FR2013/051549 (22) Date de depot international: (25) Langue de depot: (26) Langue de publication : 2 juillet 2013 (02.07.2013) frarujais frarujais (30) Donnees relatives a la priorite : 1256329 2 juillet 2012 (02.07.2012) FR (71) Deposant : SANOFI PASTEUR [FR/FR]; 2 avenue Pont Pasteur, F-69367 Lyon cedex 07 (FR). (72) Inventeurs : LE HIR, Jerome; 44 rue de la Loubiere, F- 13006 Marseille (FR). LOUBIERE, Pascal; 9 chemin de Pellegri, F-31450 Donneville (FR). BARBIRATO, Fa- Publiee bien; 5 rue Victor Hugo, F-69530 Brignais (FR). LIND- LEY, Nicholas; La Vergnerie basse, F-81310 Parisot (FR). (81) Etats designes (sauf indication contraire, pour tout titre de protection nationale disponible) : AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Etats designes (sauf indication contraire, pour tout titre de protection regionale disponible) : ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), eurasien (AM, AZ, BY, KG, KZ, RU, TJ, TM), europeen (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). : — avec rapport de recherche internationale (Art. 21(3)) 00 i-H m o o o CJ (54) Title : METHOD FOR PRODUCING HAEMOPHILUS INFLUENZAE TYPE B ANTIGENS (54) Titre : PROCEDE DE PRODUCTION D'ANTIGENES HAEMOPHILUS INFLUENZAE TYPE B (57) Abstract : The invention concerns method a for producing, on an industrial scale, capsular polysaccharide of Haemophilus in fluenzae type (PRP) b intended for vaccine purposes, according to which strain of a Haemophilus influenzae type b (Hib) is cultured in culture medium, a the culture supernatant is harvested and treated in order to extract the capsular polysaccharide therefrom, said culture medium comprising at least: - one source of carbon, - protoporphyrin, - salts, - amino acids, - NAD or NADH, vitamins, - - means for regulating the pH, characterised in that said culture medium is chemically defined. (57) Abrege : L'invention pour a objet un precede pour la production a l'echelle industrielle, de polysaccharide capsulaire de Hae mophilus influenzae type b (PRP) destine des a fins vaccinales, selon lequel on cultive une souche d' Haemophilus influenzae type b (Hib) dans un milieu de culture, on recueille le surnageant de culture que l'on traite pour en extraire le polysaccharide capsulaire, le- dit milieu de culture comprenant au moins: -une source de carbone, -de la protoporphyrine, -des sels, -des acides amines, -du NAD ou NADH, -des vitamines, -des moyens de regulation du p H, caracterise en ce que ledit milieu de culture est chimiquement defini.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1256329A FR2992656B1 (en) | 2012-07-02 | 2012-07-02 | METHOD FOR PRODUCING ANTIGENS HAEMOPHILUS INFLUENZAE TYPE B |
| PCT/FR2013/051549 WO2014006318A1 (en) | 2012-07-02 | 2013-07-02 | Method for producing haemophilus influenzae type b antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201408194SA true SG11201408194SA (en) | 2015-01-29 |
Family
ID=47666183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201408194SA SG11201408194SA (en) | 2012-07-02 | 2013-07-02 | Method for producing haemophilus influenzae type b antigens |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US9556464B2 (en) |
| EP (1) | EP2885397B1 (en) |
| JP (1) | JP6347778B2 (en) |
| KR (1) | KR102051482B1 (en) |
| CN (1) | CN104583390B (en) |
| AU (1) | AU2013285306B2 (en) |
| BR (1) | BR112014033082B1 (en) |
| CA (1) | CA2878053C (en) |
| CR (1) | CR20140559A (en) |
| CY (1) | CY1120465T1 (en) |
| DK (1) | DK2885397T3 (en) |
| ES (1) | ES2681993T3 (en) |
| FR (1) | FR2992656B1 (en) |
| GE (1) | GEP201706788B (en) |
| HK (1) | HK1208493A1 (en) |
| HR (1) | HRP20181206T1 (en) |
| HU (1) | HUE038865T2 (en) |
| IL (1) | IL236208A0 (en) |
| LT (1) | LT2885397T (en) |
| MX (1) | MX358953B (en) |
| NZ (1) | NZ702471A (en) |
| PE (1) | PE20150192A1 (en) |
| PH (1) | PH12014502730B1 (en) |
| PL (1) | PL2885397T3 (en) |
| PT (1) | PT2885397T (en) |
| RS (1) | RS57495B1 (en) |
| RU (1) | RU2644246C2 (en) |
| SG (1) | SG11201408194SA (en) |
| SI (1) | SI2885397T1 (en) |
| TR (1) | TR201810678T4 (en) |
| UA (1) | UA115787C2 (en) |
| WO (1) | WO2014006318A1 (en) |
| ZA (2) | ZA201500014B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2624014C1 (en) * | 2016-04-08 | 2017-06-30 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства России (ФГУП СПбНИИВС ФМБА России) | Haemophilus influenzae spb strain type b - highly active producer of capsular polyribosylribitolphosphate polysaccharide |
| US11027005B2 (en) | 2016-10-20 | 2021-06-08 | Km Biologics Co., Ltd. | Method for producing Hib conjugate vaccine using PRP with lowered molecular weight |
| UA127497C2 (en) * | 2017-04-22 | 2023-09-13 | Байолоджикал Е Лімітед | An improved method for high level production of crm |
| RU2704452C1 (en) * | 2019-04-22 | 2019-10-28 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства | Method of producing a hemophilic b type conjugated vaccine |
| CN109975559B (en) * | 2019-04-29 | 2023-07-11 | 厦门稀土材料研究所 | Kit and method for time-resolved fluorescence quantitative detection of 25-hydroxy vitamin D |
| CN111000994A (en) * | 2019-12-26 | 2020-04-14 | 北京科兴中维生物技术有限公司 | Liquid vaccine composition, preparation method and application thereof |
| CN112212779B (en) * | 2020-09-04 | 2022-05-17 | 厦门大学 | Preparation method of hydrogel flexible strain sensor |
| KR20220072781A (en) * | 2020-11-25 | 2022-06-02 | 주식회사 엘지화학 | Method of Quality Evaluation for Purification Process of PRP Antigen of Haemophilus Influenza Type b |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03183416A (en) * | 1989-12-12 | 1991-08-09 | Shozo Oyama | Cultivation of mycorrhizal fungus and preparation of fruit body of the fungus |
| FR2791895B1 (en) * | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | USE OF TREHALOSE TO STABILIZE A LIQUID VACCINE |
| RU2258737C2 (en) * | 2003-09-01 | 2005-08-20 | Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН | Nutrient medium for culturing microorganism haemophilus influenzae type b |
| FR2914302A1 (en) * | 2007-03-30 | 2008-10-03 | Sanofi Pasteur Sa | PROCESS FOR PREPARING PORPHYRIN DERIVATIVES, SUCH AS PROTOPORPHYRIN (IX) AND INTERMEDIATE SYNTHESIS |
| FR2918671B1 (en) * | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | GROWING MEDIUM OF HAEMOPHILUS INFLUENZAE TYPE B. |
| GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| PE20100366A1 (en) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | NOVEL COMPOSITIONS OF VACCINE WITH CELLULAR WHOOUS COUGH AS WELL AS THE METHOD FOR ITS ELABORATION |
| TW201129698A (en) * | 2009-12-10 | 2011-09-01 | Jgc Corp | New cell culture method |
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2012
- 2012-07-02 FR FR1256329A patent/FR2992656B1/en active Active
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2013
- 2013-07-02 BR BR112014033082-4A patent/BR112014033082B1/en active IP Right Grant
- 2013-07-02 HU HUE13744668A patent/HUE038865T2/en unknown
- 2013-07-02 US US14/411,241 patent/US9556464B2/en active Active
- 2013-07-02 RS RS20180874A patent/RS57495B1/en unknown
- 2013-07-02 AU AU2013285306A patent/AU2013285306B2/en active Active
- 2013-07-02 DK DK13744668.8T patent/DK2885397T3/en active
- 2013-07-02 GE GEAP201313708A patent/GEP201706788B/en unknown
- 2013-07-02 PE PE2014002572A patent/PE20150192A1/en not_active Application Discontinuation
- 2013-07-02 SI SI201331114T patent/SI2885397T1/en unknown
- 2013-07-02 ES ES13744668.8T patent/ES2681993T3/en active Active
- 2013-07-02 CA CA2878053A patent/CA2878053C/en active Active
- 2013-07-02 EP EP13744668.8A patent/EP2885397B1/en active Active
- 2013-07-02 SG SG11201408194SA patent/SG11201408194SA/en unknown
- 2013-07-02 NZ NZ702471A patent/NZ702471A/en unknown
- 2013-07-02 RU RU2015103140A patent/RU2644246C2/en active
- 2013-07-02 TR TR2018/10678T patent/TR201810678T4/en unknown
- 2013-07-02 UA UAA201500772A patent/UA115787C2/en unknown
- 2013-07-02 CN CN201380035582.0A patent/CN104583390B/en active Active
- 2013-07-02 LT LTEP13744668.8T patent/LT2885397T/en unknown
- 2013-07-02 PL PL13744668T patent/PL2885397T3/en unknown
- 2013-07-02 JP JP2015519306A patent/JP6347778B2/en active Active
- 2013-07-02 MX MX2014014607A patent/MX358953B/en active IP Right Grant
- 2013-07-02 WO PCT/FR2013/051549 patent/WO2014006318A1/en active Application Filing
- 2013-07-02 PT PT137446688T patent/PT2885397T/en unknown
- 2013-07-02 KR KR1020157002676A patent/KR102051482B1/en active IP Right Grant
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2014
- 2014-12-04 CR CR20140559A patent/CR20140559A/en unknown
- 2014-12-05 PH PH12014502730A patent/PH12014502730B1/en unknown
- 2014-12-11 IL IL236208A patent/IL236208A0/en active IP Right Grant
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2015
- 2015-01-05 ZA ZA2015/00014A patent/ZA201500014B/en unknown
- 2015-01-05 ZA ZA2015/00028A patent/ZA201500028B/en unknown
- 2015-09-16 HK HK15109036.0A patent/HK1208493A1/en unknown
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2016
- 2016-12-16 US US15/381,436 patent/US10144940B2/en active Active
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2018
- 2018-07-25 CY CY20181100777T patent/CY1120465T1/en unknown
- 2018-07-25 HR HRP20181206TT patent/HRP20181206T1/en unknown
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