CN104540827B - 吡咯并苯并二氮杂卓 - Google Patents

吡咯并苯并二氮杂卓 Download PDF

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Publication number
CN104540827B
CN104540827B CN201380035161.8A CN201380035161A CN104540827B CN 104540827 B CN104540827 B CN 104540827B CN 201380035161 A CN201380035161 A CN 201380035161A CN 104540827 B CN104540827 B CN 104540827B
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CN
China
Prior art keywords
nme
alkyl
group
compound
phenyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380035161.8A
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English (en)
Chinese (zh)
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CN104540827A (zh
Inventor
菲利普·威尔逊·霍华德
戴维·埃德温·瑟斯顿
洪达克·米拉祖尔·拉赫曼
彼得·威廉·泰勒
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MedImmune Ltd
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MedImmune Ltd
ADC Products UK Ltd
UCL Business Ltd
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Publication of CN104540827A publication Critical patent/CN104540827A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201380035161.8A 2012-04-30 2013-04-30 吡咯并苯并二氮杂卓 Expired - Fee Related CN104540827B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
US61/640,316 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
CN104540827A CN104540827A (zh) 2015-04-22
CN104540827B true CN104540827B (zh) 2018-03-23

Family

ID=48289484

Family Applications (1)

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CN201380035161.8A Expired - Fee Related CN104540827B (zh) 2012-04-30 2013-04-30 吡咯并苯并二氮杂卓

Country Status (14)

Country Link
US (1) US9321774B2 (enExample)
EP (1) EP2855481A1 (enExample)
JP (1) JP6125614B2 (enExample)
KR (1) KR101960130B1 (enExample)
CN (1) CN104540827B (enExample)
AU (1) AU2013255612B2 (enExample)
BR (1) BR112014027190B1 (enExample)
CA (1) CA2872205C (enExample)
HK (1) HK1208217A1 (enExample)
IN (1) IN2014MN02175A (enExample)
MX (1) MX2014013144A (enExample)
NZ (1) NZ701478A (enExample)
WO (1) WO2013164592A1 (enExample)
ZA (1) ZA201408043B (enExample)

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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
KR20200032243A (ko) 2017-02-08 2020-03-25 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
IL301638B2 (en) 2017-09-29 2024-09-01 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
EP3717021A1 (en) 2017-11-27 2020-10-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
IL286326B2 (en) 2019-03-15 2025-10-01 Medimmune Ltd Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer
KR20210086557A (ko) 2019-12-31 2021-07-08 주식회사 레고켐 바이오사이언스 피롤로벤조디아제핀 유도체 및 이의 리간드-링커 접합체
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
AU2023298568A1 (en) 2022-06-30 2025-01-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
AU2023393382A1 (en) 2022-12-14 2025-06-19 Pheon Therapeutics Ltd Cytotoxic compounds

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Also Published As

Publication number Publication date
NZ701478A (en) 2016-08-26
CA2872205C (en) 2020-07-21
CA2872205A1 (en) 2013-11-07
US20150126495A1 (en) 2015-05-07
US9321774B2 (en) 2016-04-26
JP6125614B2 (ja) 2017-05-10
BR112014027190A2 (pt) 2017-06-27
JP2015516987A (ja) 2015-06-18
AU2013255612A1 (en) 2014-11-20
IN2014MN02175A (enExample) 2015-08-28
BR112014027190B1 (pt) 2020-03-03
MX2014013144A (es) 2015-05-11
HK1208217A1 (en) 2016-02-26
ZA201408043B (en) 2017-08-30
AU2013255612B2 (en) 2017-06-22
KR101960130B1 (ko) 2019-03-19
EP2855481A1 (en) 2015-04-08
CN104540827A (zh) 2015-04-22
WO2013164592A1 (en) 2013-11-07
KR20150014935A (ko) 2015-02-09

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