JP6125614B2 - ピロロベンゾジアゼピン - Google Patents

ピロロベンゾジアゼピン Download PDF

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Publication number
JP6125614B2
JP6125614B2 JP2015509487A JP2015509487A JP6125614B2 JP 6125614 B2 JP6125614 B2 JP 6125614B2 JP 2015509487 A JP2015509487 A JP 2015509487A JP 2015509487 A JP2015509487 A JP 2015509487A JP 6125614 B2 JP6125614 B2 JP 6125614B2
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compound according
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Japanese (ja)
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JP2015516987A (ja
Inventor
フィリップ・ウィルソン・ハワード
デイビッド・エドウィン・サーストン
コンデーカー・ミラズール・ラフマーン
ピーター・ウィリアム・テイラー
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MedImmune Ltd
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015509487A 2012-04-30 2013-04-30 ピロロベンゾジアゼピン Active JP6125614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
US61/640,316 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
JP2015516987A JP2015516987A (ja) 2015-06-18
JP6125614B2 true JP6125614B2 (ja) 2017-05-10

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015509487A Active JP6125614B2 (ja) 2012-04-30 2013-04-30 ピロロベンゾジアゼピン

Country Status (14)

Country Link
US (1) US9321774B2 (enExample)
EP (1) EP2855481A1 (enExample)
JP (1) JP6125614B2 (enExample)
KR (1) KR101960130B1 (enExample)
CN (1) CN104540827B (enExample)
AU (1) AU2013255612B2 (enExample)
BR (1) BR112014027190B1 (enExample)
CA (1) CA2872205C (enExample)
HK (1) HK1208217A1 (enExample)
IN (1) IN2014MN02175A (enExample)
MX (1) MX2014013144A (enExample)
NZ (1) NZ701478A (enExample)
WO (1) WO2013164592A1 (enExample)
ZA (1) ZA201408043B (enExample)

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BR112014008888A2 (pt) 2011-10-14 2017-04-18 Seattle Genetics Inc pirrolobenzodiazepinas
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CN103997893B (zh) 2011-10-14 2019-04-12 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
PT3470086T (pt) 2012-10-12 2021-02-01 Medimmune Ltd Pirrolobenzodiazepinas e conjugados das mesmas
CA2885340C (en) 2012-10-12 2016-11-08 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
JP6367204B2 (ja) 2012-10-12 2018-08-01 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ 結合用のピロロベンゾジアゼピン誘導体の合成および中間体
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BR112015014669B1 (pt) 2012-12-21 2023-09-26 Medimmune Limited Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa
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GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
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JP7049276B2 (ja) * 2016-06-24 2022-04-06 メルサナ セラピューティクス インコーポレイテッド ピロロベンゾジアゼピンおよびその結合体
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
MX375569B (es) 2017-02-08 2025-03-04 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
JP7408396B2 (ja) 2017-04-20 2024-01-05 アーデーセー セラピューティクス ソシエテ アノニム 併用療法
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
KR102312910B1 (ko) 2017-08-18 2021-10-15 메디뮨 리미티드 피롤로벤조디아제핀 컨쥬게이트
TWI885539B (zh) 2017-09-29 2025-06-01 日商第一三共股份有限公司 抗體－吡咯并苯二氮呯衍生物複合體
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GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
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GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
SG11202108900WA (en) 2019-03-15 2021-09-29 Medimmune Ltd Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
US20230310640A1 (en) 2019-12-31 2023-10-05 Legochem Biosciences, Inc. Pyrrolobenzodiazepine derivative and ligand-linker conjugate thereof
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
CN119486758A (zh) 2022-06-30 2025-02-18 东丽株式会社 癌的治疗和/或预防用药物组合物
KR20250135788A (ko) 2022-12-14 2025-09-15 페온 테라퓨틱스 리미티드 세포독성 화합물
WO2025262641A1 (en) 2024-06-19 2025-12-26 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof

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Also Published As

Publication number Publication date
ZA201408043B (en) 2017-08-30
AU2013255612B2 (en) 2017-06-22
US9321774B2 (en) 2016-04-26
NZ701478A (en) 2016-08-26
BR112014027190A2 (pt) 2017-06-27
CA2872205C (en) 2020-07-21
CN104540827B (zh) 2018-03-23
AU2013255612A1 (en) 2014-11-20
IN2014MN02175A (enExample) 2015-08-28
JP2015516987A (ja) 2015-06-18
US20150126495A1 (en) 2015-05-07
EP2855481A1 (en) 2015-04-08
CA2872205A1 (en) 2013-11-07
MX2014013144A (es) 2015-05-11
KR20150014935A (ko) 2015-02-09
CN104540827A (zh) 2015-04-22
KR101960130B1 (ko) 2019-03-19
HK1208217A1 (en) 2016-02-26
BR112014027190B1 (pt) 2020-03-03
WO2013164592A1 (en) 2013-11-07

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