CN104507942B - 作为蛋白质激酶抑制剂的吡啶并嘧啶衍生物 - Google Patents

作为蛋白质激酶抑制剂的吡啶并嘧啶衍生物 Download PDF

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Publication number
CN104507942B
CN104507942B CN201380041839.3A CN201380041839A CN104507942B CN 104507942 B CN104507942 B CN 104507942B CN 201380041839 A CN201380041839 A CN 201380041839A CN 104507942 B CN104507942 B CN 104507942B
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mmol
compound
equiv
pyrido
room temperature
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CN104507942A (zh
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L.布格多夫
D.库恩
T.罗斯
C.多伊奇
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Merck Patent GmbH
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Merck Patent GmbH
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  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
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CN201380041839.3A 2012-08-07 2013-07-10 作为蛋白质激酶抑制剂的吡啶并嘧啶衍生物 Expired - Fee Related CN104507942B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12005716 2012-08-07
EP12005716.1 2012-08-07
PCT/EP2013/002032 WO2014023385A1 (en) 2012-08-07 2013-07-10 Pyridopyrimidine derivatives as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CN104507942A CN104507942A (zh) 2015-04-08
CN104507942B true CN104507942B (zh) 2017-03-22

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US (1) US9725462B2 (enExample)
EP (1) EP2882746B1 (enExample)
JP (2) JP6374384B2 (enExample)
CN (1) CN104507942B (enExample)
AR (1) AR092365A1 (enExample)
AU (1) AU2013301865B2 (enExample)
CA (1) CA2881279C (enExample)
ES (1) ES2618004T3 (enExample)
IL (1) IL237073A (enExample)
WO (1) WO2014023385A1 (enExample)

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EP2817308B1 (en) * 2012-02-23 2016-09-07 AbbVie Inc. Pyridopyrimidinone inhibitors of kinases
EP2882746B1 (en) * 2012-08-07 2016-12-07 Merck Patent GmbH Pyridopyrimidine derivatives as protein kinase inhibitors
KR20140027714A (ko) * 2012-08-27 2014-03-07 주식회사 홍인터내셔날 외부 디바이스와 연동하는 다트 게임 장치
RU2732576C2 (ru) * 2015-07-21 2020-09-21 Гуанчжоу Максиновел Фармасьютикалс Ко., Лтд. Пиримидиновое соединение с конденсированными кольцами, его промежуточное соединение, способ получения, композиция и применение
KR102598895B1 (ko) 2016-07-12 2023-11-07 레볼루션 메디슨즈, 인크. 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
NZ754364A (en) 2016-12-22 2023-04-28 Calithera Biosciences Inc Compositions and methods for inhibiting arginase activity
JP7240319B2 (ja) 2017-01-23 2023-03-15 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としての二環式化合物
KR20190110588A (ko) 2017-01-23 2019-09-30 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 피리딘 화합물
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
US20200291018A1 (en) * 2017-07-13 2020-09-17 Syros Pharmaceuticals, Inc. Tam kinase inhibitors
ES2928576T3 (es) 2017-09-08 2022-11-21 Amgen Inc Inhibidores de KRAS G12C y métodos de uso de los mismos
MX2020003579A (es) 2017-10-12 2020-07-22 Revolution Medicines Inc Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
WO2019100106A1 (en) * 2017-11-24 2019-05-31 The University Of Sydney Antibacterial compounds and methods of use thereof
TW201927791A (zh) 2017-12-15 2019-07-16 美商銳新醫藥公司 作為變構shp2抑制劑的多環化合物
MA52501A (fr) 2018-05-04 2021-03-10 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
MA51848A (fr) 2018-06-12 2021-04-21 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
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