JP6374384B2 - プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 - Google Patents

プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 Download PDF

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JP6374384B2
JP6374384B2 JP2015525760A JP2015525760A JP6374384B2 JP 6374384 B2 JP6374384 B2 JP 6374384B2 JP 2015525760 A JP2015525760 A JP 2015525760A JP 2015525760 A JP2015525760 A JP 2015525760A JP 6374384 B2 JP6374384 B2 JP 6374384B2
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mmol
pyrido
pyrimidin
added
cancer
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JP2015529657A (ja
JP2015529657A5 (enExample
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バークドルフ，ラース
クーン，ダニエル
ロス，タトジャナ
ドゥトッシュ，カール
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2015525760A 2012-08-07 2013-07-10 プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 Expired - Fee Related JP6374384B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12005716.1 2012-08-07
EP12005716 2012-08-07
PCT/EP2013/002032 WO2014023385A1 (en) 2012-08-07 2013-07-10 Pyridopyrimidine derivatives as protein kinase inhibitors

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JP2018076582A Division JP2018150307A (ja) 2012-08-07 2018-04-12 プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体

Publications (3)

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JP2015529657A JP2015529657A (ja) 2015-10-08
JP2015529657A5 JP2015529657A5 (enExample) 2017-09-28
JP6374384B2 true JP6374384B2 (ja) 2018-08-15

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JP2015525760A Expired - Fee Related JP6374384B2 (ja) 2012-08-07 2013-07-10 プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体
JP2018076582A Pending JP2018150307A (ja) 2012-08-07 2018-04-12 プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体

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US (1) US9725462B2 (enExample)
EP (1) EP2882746B1 (enExample)
JP (2) JP6374384B2 (enExample)
CN (1) CN104507942B (enExample)
AR (1) AR092365A1 (enExample)
AU (1) AU2013301865B2 (enExample)
CA (1) CA2881279C (enExample)
ES (1) ES2618004T3 (enExample)
IL (1) IL237073A (enExample)
WO (1) WO2014023385A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018150307A (ja) * 2012-08-07 2018-09-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体

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US10494378B2 (en) 2015-07-21 2019-12-03 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Fused ring pyrimidine compound, intermediate, and preparation method, composition and use thereof
IL311645B2 (en) 2016-07-12 2025-11-01 Revolution Medicines Inc 2,5- disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines asallosteric shp2 inhibitors
WO2018119440A1 (en) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CN110446709B (zh) 2017-01-23 2023-09-12 锐新医药公司 作为变构shp2抑制剂的二环化合物
CA3051054A1 (en) 2017-01-23 2018-07-26 Revolution Medicines, Inc. Pyridine compounds as allosteric shp2 inhibitors
UA127968C2 (uk) 2017-05-22 2024-02-28 Емджен Інк. Інгібітори g12c kras і способи їх застосування
EP3652174A4 (en) * 2017-07-13 2021-06-30 Syros Pharmaceuticals, Inc. TAM KINASE INHIBITORS
US10640504B2 (en) 2017-09-08 2020-05-05 Amgen Inc. Inhibitors of KRAS G12C and methods of using the same
BR112020007058A2 (pt) 2017-10-12 2020-10-06 Revolution Medicines, Inc. compostos de piridina, pirazina, e triazina como inibidores de shp2 alostéricos
WO2019100106A1 (en) * 2017-11-24 2019-05-31 The University Of Sydney Antibacterial compounds and methods of use thereof
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