CN1043897C - 膦酸二酯衍生物 - Google Patents

膦酸二酯衍生物 Download PDF

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Publication number
CN1043897C
CN1043897C CN94190705A CN94190705A CN1043897C CN 1043897 C CN1043897 C CN 1043897C CN 94190705 A CN94190705 A CN 94190705A CN 94190705 A CN94190705 A CN 94190705A CN 1043897 C CN1043897 C CN 1043897C
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CN
China
Prior art keywords
reaction
formula
halogen atom
compound
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94190705A
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English (en)
Chinese (zh)
Other versions
CN1114835A (zh
Inventor
宫田一义
黑木保久
津田可彦
堤一彦
岩本武史
奈波智惠子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Publication of CN1114835A publication Critical patent/CN1114835A/zh
Application granted granted Critical
Publication of CN1043897C publication Critical patent/CN1043897C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN94190705A 1993-08-20 1994-08-08 膦酸二酯衍生物 Expired - Fee Related CN1043897C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20625993 1993-08-20
JP206259/93 1993-08-20

Publications (2)

Publication Number Publication Date
CN1114835A CN1114835A (zh) 1996-01-10
CN1043897C true CN1043897C (zh) 1999-06-30

Family

ID=16520375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190705A Expired - Fee Related CN1043897C (zh) 1993-08-20 1994-08-08 膦酸二酯衍生物

Country Status (12)

Country Link
US (1) US5527786A (enExample)
EP (1) EP0666265B1 (enExample)
JP (1) JP3074332B2 (enExample)
KR (1) KR100305959B1 (enExample)
CN (1) CN1043897C (enExample)
AT (1) ATE189224T1 (enExample)
AU (1) AU678276B2 (enExample)
CA (1) CA2147375C (enExample)
DE (1) DE69422793T2 (enExample)
ES (1) ES2141830T3 (enExample)
TW (1) TW268008B (enExample)
WO (1) WO1995006051A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3533542B2 (ja) * 1994-03-08 2004-05-31 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
JP2012525331A (ja) * 2009-04-27 2012-10-22 リメリック バイオファーマ， インコーポレイテッド 治療的処置のためのリン酸化ピロン類似体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232010A (en) * 1978-05-15 1980-11-04 Kanebo, Ltd. Calcium-antagonistic composition
JPH04243888A (ja) * 1991-01-24 1992-08-31 Otsuka Pharmaceut Factory Inc イミダゾ［１，２−ａ］ピリジン誘導体、その製造方法及びその中間体としてのα−ハロケトン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH471113A (de) * 1965-01-29 1969-04-15 Merck Ag E Verfahren zur Herstellung von wasserlöslichen Flavanoidderivaten
US4434162A (en) * 1981-02-17 1984-02-28 Kanebo, Ltd. Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same
JPS5851958B2 (ja) * 1982-01-30 1983-11-19 カネボウ株式会社 新規１−（ベンゾチアゾ−ル−２−イル）−４−ジエトキシ−又はジイソプロポキシ−ホスフイニルベンゼン
US4870199A (en) * 1986-04-30 1989-09-26 Sandoz Pharm. Corp. Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
JP2584336B2 (ja) * 1989-05-30 1997-02-26 株式会社大塚製薬工場 カルボン酸アミド誘導体
JP2696150B2 (ja) * 1991-02-05 1998-01-14 株式会社大塚製薬工場 キノリン誘導体
JP2869608B2 (ja) * 1992-04-28 1999-03-10 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232010A (en) * 1978-05-15 1980-11-04 Kanebo, Ltd. Calcium-antagonistic composition
JPH04243888A (ja) * 1991-01-24 1992-08-31 Otsuka Pharmaceut Factory Inc イミダゾ［１，２−ａ］ピリジン誘導体、その製造方法及びその中間体としてのα−ハロケトン誘導体

Also Published As

Publication number Publication date
AU678276B2 (en) 1997-05-22
US5527786A (en) 1996-06-18
AU7276394A (en) 1995-03-21
WO1995006051A1 (en) 1995-03-02
DE69422793T2 (de) 2000-06-21
JP3074332B2 (ja) 2000-08-07
KR950704335A (ko) 1995-11-17
TW268008B (enExample) 1996-01-11
CA2147375A1 (en) 1995-03-02
KR100305959B1 (ko) 2001-12-28
DE69422793D1 (de) 2000-03-02
ES2141830T3 (es) 2000-04-01
CA2147375C (en) 2003-02-11
ATE189224T1 (de) 2000-02-15
EP0666265A1 (en) 1995-08-09
CN1114835A (zh) 1996-01-10
EP0666265A4 (en) 1996-04-17
EP0666265B1 (en) 2000-01-26

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CF01 Termination of patent right due to non-payment of annual fee