CN104381267A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN104381267A CN104381267A CN201410751762.5A CN201410751762A CN104381267A CN 104381267 A CN104381267 A CN 104381267A CN 201410751762 A CN201410751762 A CN 201410751762A CN 104381267 A CN104381267 A CN 104381267A
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- mandipropamid
- piperazine mycin
- shen piperazine
- bactericidal composition
- shen
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Abstract
The invention belongs to the technical field of pesticide and relates to a bactericidal composition. The bactericidal composition is characterized by comprising active components, mandipropamid and phenazino-1-carboxylic acid. The composition can be in forms of suspending agents and water dispersible granules, has remarkable synergism, and is environment-friendly, the lasting period of the bactericidal composition is prolonged and the using cost can be reduced.
Description
Technical field
The invention belongs to technical field of pesticide, contain the composite bactericide with synergistic effect of mandipropamid and Shen piperazine mycin specifically.
Background technology
Mandipropamid belongs to acid amide fungicides, and its mechanism of action is suppress the biosynthesis of phosphatide, all has good preventive effect to large absolutely number by ovum microbial leaf portion and fruit disease.To the spore being in the sprouting stage, there is higher activity, and mycelia can be suppressed to grow up and sporulation.Can be rapidly absorbed by blade, and rest in leaf table wax coat, blade is shielded.Mandipropamid has special efficacy to the disease that lower fungus causes, to downy mildew, capsicum and phytophthora root rot cucurbitaceous, potato late blight.This product is low toxicity to fish, bird, honeybee, silkworm.
Shen piperazine mycin (phenazino-1-carboxylic acid) is a kind of antibiotic secreted through biological culture by pseudomonas fluorescens, there is wide spectrum Suppressing phytopathogens simultaneously and the dual-use function of Promoting plant growth effect, this biological bactericide has wide spectrum, efficient feature, effectively can prevent and treat paddy rice, wheat, fusarium wilt on the crops such as vegetables, blight dis-ease, epidemic disease, banded sclerotial blight, false smut, rice blast, downy mildew, yellow rust, stalk break, head blight, anthracnose, gray mold, scab, leaf spot, bacterial wilt, canker, ginger plague and soil-borne disease soil treatment.
Potato late blight (Potato Late Bright) is caused by phytophthora infestans, causes the crushing oomycetes disease of one that potato haulm is dead and stem tuber is rotten.Serious blade of falling ill wither vertical, crispatura, cause the black corruption of complete stool eventually, full field a slice is dried-up, gives out corrupt smell.Stem tuber is caught an illness nascent brown or puce bulk scab, slightly caves in, and the subcutaneous potato meat in sick portion, also in brown, slowly expands to surrounding or rots, having a strong impact on output.
The agricultural chemicals of current use mostly is synthetic, and the intermediate having a lot of high poison in the overweight process of synthesis produces, and the use of a large amount of chemical pesticide has increasingly sharpened on the impact of environment.For current present situation, people start more to be conceived to the free of contamination biogenic pesticide of more low toxic and environment-friendly, because biogenic pesticide utilizes the antagonist properties between microorganism to prevent and treat pathogen, this is more efficient and environmental protection than existing chemosynthesis composition, new varieties and the complex preparation of current exploitation biogenic pesticide are more and more subject to people's attention, and relate in the present invention two kinds of active ingredient one are biogenic pesticide, and another kind is low toxicity and low residue new high-efficiency chemical pesticide.We by mandipropamid and Shen piperazine mycin composite, to the drug effect both strengthening, expand fungicidal spectrum, reduce the labour cost of peasant.
Summary of the invention
The object of this invention is to provide and a kind ofly there is synergistic effect and the bactericidal composition of safety and environmental protection, realize improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to mandipropamid and the composite bactericidal composition of Shen piperazine mycin.
Utilize the bactericidal composition described in the invention described above, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, comprise water dispersible granules and suspending agent.
In above-mentioned composite bactericide, the weight ratio of mandipropamid and Shen piperazine mycin is 1:100-100:1.
Above-mentioned composite bactericide has following characteristics: 1. biogenic pesticide, little to environmental influence; 2. utilize the antagonism between microorganism to carry out sterilization, effect is strong; 3. formulation environmental protection, does not add organic principle; 4. two kinds of compositions are composite, have synergistic effect; 5. between two-component without cross resistance; 6. delay the generation of active ingredient resistance, reduce the labour cost of peasant.
Embodiment
For determining mandipropamid and the composite synergistic effect of Shen piperazine mycin two kinds of active ingredients, first applicant uses these two kinds of compositions to carry out indoor biometrics test, test method and result as follows:
First, after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be and claims phytophthora infestans (Phytophthora infestans de Bary) by we, belongs to Mastigomycotina fungi.Sporangiophore branch, every one section the joint that expands of raw sporangium place tool.Sporangium lemon shape, size 2 ~ 38 × 12 ~ 23 (um), one end tool mastoid process, another end has stalklet, easily comes off, and discharges 5 ~ 9 kidney shape zoospores in water.Zoospore tool flagellum 2, becomes the spore that stops after losing flagellum, sprouts germ tube, and raw penetration peg invades in pin main body again.This bacterium can cause potato late blight.
The test method of indoor biometrics: adopt growth rate method to measure the inhibitory action of medicament Phytophthora infestans silk growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the former medicine of 93% mandipropamid and the 70% Shen former medicine of piperazine mycin with acetone to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking Rhizoctonia solani Kuhn bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics test data sees the following form:
Table 1 mandipropamid, Shen piperazine mycin and different ratio thereof are to the measurement result of potato late blight pathogen co-toxicity coefficient
Analyze above-mentioned data can find out, when mandipropamid and Shen piperazine mycin are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of potato late blight is had to the synergistic effect of different proportion, visible, the complex preparation of mandipropamid and Shen piperazine mycin, can become the favourable agents preventing and treating potato late blight.
Tested by indoor biometrics, determine mandipropamid and Shen piperazine mycin two kinds of active ingredients composite after, can have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Example one, 10.1% mandipropamid Shen piperazine mycin suspending agent
Example two, 25.5% mandipropamid Shen piperazine mycin water dispersible granules
Example three, 31% mandipropamid Shen piperazine mycin suspending agent
Example four, 8.8% mandipropamid Shen piperazine mycin water dispersible granules
Example five, 6% mandipropamid Shen piperazine mycin suspending agent
Example six, 3% mandipropamid Shen piperazine mycin water dispersible granules
Example seven, 6.6% mandipropamid Shen piperazine mycin suspending agent
Example eight, 30.6% mandipropamid Shen piperazine mycin water dispersible granules
Example nine, 20.2% mandipropamid Shen piperazine mycin suspending agent
Example ten, 20% mandipropamid Shen piperazine mycin water dispersible granules
Select above example to carry out preventing and treating the field trial of potato late blight, determine to fill a prescription and prevent and treat the effect of potato late blight; Simultaneously by the Contrast on effect with mandipropamid and Shen piperazine mycin single dose, verify composite after synergistic effect.Concrete test method and data as follows:
The field control effectiveness test of potato late blight prevented and treated by 6% mandipropamid Shen piperazine mycin suspending agent and other preparation.Test site is Luliang county, and the time is on October 1st, 2013, and test each process three repetition, community randomized arrangement, each plot area is 40m
2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method: random 5 samplings in field, fixes 13 strains at often, and after secondary dispenser, 7d, 14d investigate strong leaf rate, the incidence of disease, the disease index of potato plant, calculates preventive effect.
Potato late blight grade scale:
0 grade: without scab;
1 grade: lesion area accounts for whole leaf area less than 5%:
3 grades: lesion area accounts for whole leaf area 6% ~ 10%:
5 grades: lesion area accounts for whole leaf area l1% ~ 20%:
7 grades: lesion area accounts for whole leaf area 21% ~ 50%:
9 grades: lesion area accounts for whole leaf area more than 50%.
Table 3 20.8% mandipropamid Shen piperazine mycin suspending agent and different agents are to the preventive effect of potato late blight
As can be seen from above-mentioned data, mandipropamid and Shen piperazine mycin complex preparation, after medicine, 7 days preventive effects are all more than 71%, and mandipropamid single dose preventive effect of 7 days after medicine is only 48.36%, the preventive effect of Shen piperazine mycin single dose is 56.38%, compare two kinds of single doses, complex preparation has good synergistic effect.And after medicine 14 days, the lasting period of complex preparation extends, more lasting to the control efficiency of potato late blight.Complex preparation can well improve drug effect, extends the lasting period, alleviates the amount of labour of peasant, have very high practicality.
Claims (2)
1. a bactericidal composition, is characterized in that: active component is made up of mandipropamid and Shen piperazine mycin, and the weight ratio of described mandipropamid and Shen piperazine mycin is 1:100 ~ 100:1.
2. composition according to claim 1, is characterized in that: make suspending agent, water dispersible granules by active component and auxiliary material.
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| CN201410751762.5A CN104381267B (en) | 2014-12-09 | 2014-12-09 | A kind of bactericidal composition |
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| CN201410751762.5A CN104381267B (en) | 2014-12-09 | 2014-12-09 | A kind of bactericidal composition |
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| CN104381267A true CN104381267A (en) | 2015-03-04 |
| CN104381267B CN104381267B (en) | 2016-03-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105104385A (en) * | 2015-09-01 | 2015-12-02 | 河北中天邦正生物科技股份公司 | Bactericide composition and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429198A (en) * | 2000-05-17 | 2003-07-09 | 辛根塔参与股份公司 | Novel phenyl-proparylether derivatives |
| CN102395272A (en) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | Fungicidal mixtures |
| WO2014037314A2 (en) * | 2012-09-07 | 2014-03-13 | Bayer Cropscience Ag | Active compound combinations |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429198A (en) * | 2000-05-17 | 2003-07-09 | 辛根塔参与股份公司 | Novel phenyl-proparylether derivatives |
| CN102395272A (en) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | Fungicidal mixtures |
| WO2014037314A2 (en) * | 2012-09-07 | 2014-03-13 | Bayer Cropscience Ag | Active compound combinations |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105104385A (en) * | 2015-09-01 | 2015-12-02 | 河北中天邦正生物科技股份公司 | Bactericide composition and application thereof |
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Address after: 102488, Beijing, Fangshan District Star Street, No. 1 hospital green sail, No. 16, building 8 Applicant after: Beijing Yanhua Yongle Biotechnology Co., Ltd. Address before: 102488 No. 8, Liangxiang, Beijing, Fangshan District Applicant before: Beijing Yanhua Yongle Biotechnology Co., Ltd. |
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Effective date of registration: 20171215 Address after: 063600 Leting County Economic Development Zone, Tangshan City, Hebei Patentee after: Yanhua Yongle (Leting) Biological Technology Co. Ltd. Address before: 102488, Beijing, Fangshan District Star Street, No. 1 hospital green sail, No. 16, building 8 Patentee before: Beijing Yanhua Yongle Biotechnology Co., Ltd. |