CN104254519B - 贝塔丙氨酸衍生物、药学上允许的盐及包含其作为有效成分的药物组合物 - Google Patents
贝塔丙氨酸衍生物、药学上允许的盐及包含其作为有效成分的药物组合物 Download PDFInfo
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- CN104254519B CN104254519B CN201380022350.1A CN201380022350A CN104254519B CN 104254519 B CN104254519 B CN 104254519B CN 201380022350 A CN201380022350 A CN 201380022350A CN 104254519 B CN104254519 B CN 104254519B
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- phenyl
- cyclohexyl
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- propionylamino
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- 0 CCCC(N*(C=C)=CCC(C)C1CCC(CC(*I)=[U])CC1)=* Chemical compound CCCC(N*(C=C)=CCC(C)C1CCC(CC(*I)=[U])CC1)=* 0.000 description 10
- XUDVDBXAGQVOMU-XCONPDAUSA-N CC(CC[C@H](C)[Ar])[C@H]1CC[C@H](CC(N=O)O)CC1 Chemical compound CC(CC[C@H](C)[Ar])[C@H]1CC[C@H](CC(N=O)O)CC1 XUDVDBXAGQVOMU-XCONPDAUSA-N 0.000 description 1
- OAGKBUWPMROMTO-CJOLWQCUSA-N CCC(C)c(cc1)ccc1NC(CCN(C)C(C)C1C(CCC=C2)=C2C(F)=C[C@H]1C)=[U+] Chemical compound CCC(C)c(cc1)ccc1NC(CCN(C)C(C)C1C(CCC=C2)=C2C(F)=C[C@H]1C)=[U+] OAGKBUWPMROMTO-CJOLWQCUSA-N 0.000 description 1
- IAQROUKVYCFKIN-OWOJBTEDSA-N OC(C/C=C/CCC(NC1C=CC(C(CC2)CCC2NC(O)O)=CC1)=O)C(CC1)=CC=C1C1CCC(CC(C2)C2O)CC1 Chemical compound OC(C/C=C/CCC(NC1C=CC(C(CC2)CCC2NC(O)O)=CC1)=O)C(CC1)=CC=C1C1CCC(CC(C2)C2O)CC1 IAQROUKVYCFKIN-OWOJBTEDSA-N 0.000 description 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0043189 | 2012-04-25 | ||
| KR20120043189 | 2012-04-25 | ||
| KR10-2013-0045811 | 2013-04-25 | ||
| KR1020130045811A KR101472279B1 (ko) | 2012-04-25 | 2013-04-25 | 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| PCT/KR2013/003557 WO2013162298A1 (ko) | 2012-04-25 | 2013-04-25 | 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104254519A CN104254519A (zh) | 2014-12-31 |
| CN104254519B true CN104254519B (zh) | 2016-04-20 |
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| CN201380022350.1A Active CN104254519B (zh) | 2012-04-25 | 2013-04-25 | 贝塔丙氨酸衍生物、药学上允许的盐及包含其作为有效成分的药物组合物 |
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|---|---|
| US (1) | US9321728B2 (https=) |
| EP (1) | EP2842938A4 (https=) |
| JP (1) | JP2015520136A (https=) |
| KR (1) | KR101472279B1 (https=) |
| CN (1) | CN104254519B (https=) |
| BR (1) | BR112014026910A8 (https=) |
| CA (1) | CA2870886A1 (https=) |
| IN (1) | IN2014MN02135A (https=) |
| MX (1) | MX2014012937A (https=) |
| RU (1) | RU2014147220A (https=) |
| WO (1) | WO2013162298A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10882841B2 (en) | 2016-03-01 | 2021-01-05 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| CN115246774A (zh) * | 2021-04-27 | 2022-10-28 | 南昌弘益科技有限公司 | 一类新型双羰基类阿魏酸衍生物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999026921A1 (en) * | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS |
| WO2003099765A1 (en) * | 2002-05-28 | 2003-12-04 | Ono Pharmaceutical Co., Ltd. | β-ALANINE DERIVATIVE AND USE THEREOF |
| WO2011123401A1 (en) * | 2010-03-30 | 2011-10-06 | Novartis Ag | Uses of dgat1 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4261639B2 (ja) * | 1998-08-05 | 2009-04-30 | 日本曹達株式会社 | フェニルイミダゾール系抗高脂血症薬 |
| JP2003128639A (ja) * | 2001-10-25 | 2003-05-08 | Sankyo Co Ltd | ベンツアミド誘導体 |
| WO2008099221A1 (en) * | 2007-02-15 | 2008-08-21 | Prosidion Limited | Amide and urea derivatives for the treatment of metabolic diseases |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| EP2423182A4 (en) * | 2009-04-21 | 2012-11-07 | Astellas Pharma Inc | DIACYLETHYLENEDIAMINE COMPOUND |
-
2013
- 2013-04-25 MX MX2014012937A patent/MX2014012937A/es unknown
- 2013-04-25 CN CN201380022350.1A patent/CN104254519B/zh active Active
- 2013-04-25 CA CA2870886A patent/CA2870886A1/en not_active Abandoned
- 2013-04-25 US US14/396,663 patent/US9321728B2/en active Active
- 2013-04-25 BR BR112014026910A patent/BR112014026910A8/pt not_active IP Right Cessation
- 2013-04-25 JP JP2015508867A patent/JP2015520136A/ja not_active Ceased
- 2013-04-25 WO PCT/KR2013/003557 patent/WO2013162298A1/ko not_active Ceased
- 2013-04-25 KR KR1020130045811A patent/KR101472279B1/ko active Active
- 2013-04-25 EP EP13781273.1A patent/EP2842938A4/en not_active Withdrawn
- 2013-04-25 IN IN2135MUN2014 patent/IN2014MN02135A/en unknown
- 2013-04-25 RU RU2014147220A patent/RU2014147220A/ru not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999026921A1 (en) * | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | SUBSTITUTED β-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS |
| WO2003099765A1 (en) * | 2002-05-28 | 2003-12-04 | Ono Pharmaceutical Co., Ltd. | β-ALANINE DERIVATIVE AND USE THEREOF |
| WO2011123401A1 (en) * | 2010-03-30 | 2011-10-06 | Novartis Ag | Uses of dgat1 inhibitors |
Non-Patent Citations (2)
| Title |
|---|
| Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1;Robert L. Dow et al.;《ACS Med. Chem. Lett.》;20111231;407–412 * |
| New â-Alanine Derivatives Are Orally Available Glucagon Receptor Antagonists;Jesper Lau et al.;《J. Med. Chem.》;20071231;第50卷;113-128 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104254519A (zh) | 2014-12-31 |
| JP2015520136A (ja) | 2015-07-16 |
| KR101472279B1 (ko) | 2014-12-16 |
| BR112014026910A2 (pt) | 2017-06-27 |
| US9321728B2 (en) | 2016-04-26 |
| MX2014012937A (es) | 2015-05-11 |
| RU2014147220A (ru) | 2016-06-10 |
| WO2013162298A8 (ko) | 2013-12-27 |
| IN2014MN02135A (https=) | 2015-09-04 |
| EP2842938A4 (en) | 2015-12-23 |
| US20150329504A1 (en) | 2015-11-19 |
| WO2013162298A1 (ko) | 2013-10-31 |
| EP2842938A1 (en) | 2015-03-04 |
| CA2870886A1 (en) | 2013-10-31 |
| BR112014026910A8 (pt) | 2018-01-09 |
| KR20130120414A (ko) | 2013-11-04 |
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