WO2013162298A8 - 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물 - Google Patents

신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물 Download PDF

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WO2013162298A8
WO2013162298A8 PCT/KR2013/003557 KR2013003557W WO2013162298A8 WO 2013162298 A8 WO2013162298 A8 WO 2013162298A8 KR 2013003557 W KR2013003557 W KR 2013003557W WO 2013162298 A8 WO2013162298 A8 WO 2013162298A8
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WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
acceptable salts
active ingredient
alanine derivatives
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PCT/KR2013/003557
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English (en)
French (fr)
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WO2013162298A1 (ko
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안진희
파기레
이상달
김기영
정원훈
배명애
송진숙
김광록
곽현정
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한국화학연구원
주식회사 한독약품
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Application filed by 한국화학연구원, 주식회사 한독약품 filed Critical 한국화학연구원
Priority to RU2014147220A priority Critical patent/RU2014147220A/ru
Priority to MX2014012937A priority patent/MX2014012937A/es
Priority to EP13781273.1A priority patent/EP2842938A4/en
Priority to CA2870886A priority patent/CA2870886A1/en
Priority to JP2015508867A priority patent/JP2015520136A/ja
Priority to US14/396,663 priority patent/US9321728B2/en
Priority to CN201380022350.1A priority patent/CN104254519B/zh
Priority to BR112014026910A priority patent/BR112014026910A8/pt
Priority to IN2135MUN2014 priority patent/IN2014MN02135A/en
Publication of WO2013162298A1 publication Critical patent/WO2013162298A1/ko
Publication of WO2013162298A8 publication Critical patent/WO2013162298A8/ko

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Abstract

본 발명은 베타 알라닌 유도체，이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 포함하는 약학적 조성물에 관한 것이다. 본 발명의 신규한 베타 알라닌 유도체 및 이의 약제학적 허용 가능한 염은 중성지방 합성의 최종 단계를 촉매하는 효소인 DGAT1의 활성을 효과적으로 억제함으로써 비만, 이상지방혈증, 지방간, 인슐린 저항성 증후군 및 간염으로 구성된 군으로부터 선택되는 다양한 지질대사 관련 질환의 예방 또는 치료용 약제학적 조성물로 유용하게 이용될 수 있다.
PCT/KR2013/003557 2012-04-25 2013-04-25 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물 WO2013162298A1 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
RU2014147220A RU2014147220A (ru) 2012-04-25 2013-04-25 Новое бета-аланиновое производное, его фармацевтически приемлемые соли и фармацевтическая композиция, включающая его в качестве активного ингредиента
MX2014012937A MX2014012937A (es) 2012-04-25 2013-04-25 Derivados novedosos de beta-alanina, sales farmaceuticamente aceptables del los mismos y una composicion farmaceutica que comprende los mismos como el ingrediente activo.
EP13781273.1A EP2842938A4 (en) 2012-04-25 2013-04-25 NOVEL BETA-ALANINE DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AS ACTIVE INGREDIENT
CA2870886A CA2870886A1 (en) 2012-04-25 2013-04-25 Novel beta-alanine derivative, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient
JP2015508867A JP2015520136A (ja) 2012-04-25 2013-04-25 新規なベータアラニン誘導体、薬学的に許容される塩、及びそれを有効成分として含有する医薬組成物
US14/396,663 US9321728B2 (en) 2012-04-25 2013-04-25 Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient
CN201380022350.1A CN104254519B (zh) 2012-04-25 2013-04-25 贝塔丙氨酸衍生物、药学上允许的盐及包含其作为有效成分的药物组合物
BR112014026910A BR112014026910A8 (pt) 2012-04-25 2013-04-25 novo derivado de beta-alanina, seus sais farmaceuticamente aceitáveis, e composições farmacêuticas compreendendo o mesmo como ingrediente ativo.
IN2135MUN2014 IN2014MN02135A (ko) 2012-04-25 2013-04-25

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KR20120043189 2012-04-25
KR10-2012-0043189 2012-04-25
KR1020130045811A KR101472279B1 (ko) 2012-04-25 2013-04-25 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물
KR10-2013-0045811 2013-04-25

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WO2013162298A1 WO2013162298A1 (ko) 2013-10-31
WO2013162298A8 true WO2013162298A8 (ko) 2013-12-27

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EP (1) EP2842938A4 (ko)
JP (1) JP2015520136A (ko)
KR (1) KR101472279B1 (ko)
CN (1) CN104254519B (ko)
BR (1) BR112014026910A8 (ko)
CA (1) CA2870886A1 (ko)
IN (1) IN2014MN02135A (ko)
MX (1) MX2014012937A (ko)
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WO (1) WO2013162298A1 (ko)

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WO2017151786A1 (en) 2016-03-01 2017-09-08 University Of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
CN115246774A (zh) * 2021-04-27 2022-10-28 南昌弘益科技有限公司 一类新型双羰基类阿魏酸衍生物

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Publication number Priority date Publication date Assignee Title
DE69824037T2 (de) * 1997-11-24 2005-06-02 Merck & Co., Inc. Beta-alanin-derivate als zell-adhäsions-inhibitoren
JP4261639B2 (ja) * 1998-08-05 2009-04-30 日本曹達株式会社 フェニルイミダゾール系抗高脂血症薬
JP2003128639A (ja) * 2001-10-25 2003-05-08 Sankyo Co Ltd ベンツアミド誘導体
EP1533294A4 (en) 2002-05-28 2007-07-04 Ono Pharmaceutical Co BETA-ALANINE DERIVATIVE AND USE THEREOF
EP2120911A1 (en) * 2007-02-15 2009-11-25 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
US20090036425A1 (en) * 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
WO2010122968A1 (ja) * 2009-04-21 2010-10-28 アステラス製薬株式会社 ジアシルエチレンジアミン化合物
MA34097B1 (fr) * 2010-03-30 2013-03-05 Novartis Ag Utilisations d'inhibiteurs de dgat1

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CA2870886A1 (en) 2013-10-31
WO2013162298A1 (ko) 2013-10-31
EP2842938A1 (en) 2015-03-04
BR112014026910A8 (pt) 2018-01-09
IN2014MN02135A (ko) 2015-09-04
JP2015520136A (ja) 2015-07-16
RU2014147220A (ru) 2016-06-10
MX2014012937A (es) 2015-05-11
US20150329504A1 (en) 2015-11-19
US9321728B2 (en) 2016-04-26
BR112014026910A2 (pt) 2017-06-27
CN104254519A (zh) 2014-12-31
KR101472279B1 (ko) 2014-12-16
EP2842938A4 (en) 2015-12-23
KR20130120414A (ko) 2013-11-04
CN104254519B (zh) 2016-04-20

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