WO2014101295A3 - 一种詹纳斯激酶(jaks)抑制活性的异恶唑衍生物 - Google Patents
一种詹纳斯激酶(jaks)抑制活性的异恶唑衍生物 Download PDFInfo
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- WO2014101295A3 WO2014101295A3 PCT/CN2013/001648 CN2013001648W WO2014101295A3 WO 2014101295 A3 WO2014101295 A3 WO 2014101295A3 CN 2013001648 W CN2013001648 W CN 2013001648W WO 2014101295 A3 WO2014101295 A3 WO 2014101295A3
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- jaks
- janus kinases
- isoxazole derivative
- formula
- inhibits activity
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Diabetes (AREA)
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- Dermatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种詹纳斯激酶(JAKs)抑制活性的异恶唑衍生物,结构如通式I、通式II、通式IX和通式XI所示,通式中各取代基定义如说明书所述。还公开了所述化合物的药物组合物及相关制药用途。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210579810.8 | 2012-12-28 | ||
CN201210579810.8A CN103896946B (zh) | 2012-12-28 | 2012-12-28 | 用于预防及治疗多种自身免疫疾病的新化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014101295A2 WO2014101295A2 (zh) | 2014-07-03 |
WO2014101295A3 true WO2014101295A3 (zh) | 2014-08-14 |
Family
ID=50988563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2013/001648 WO2014101295A2 (zh) | 2012-12-28 | 2013-12-26 | 一种詹纳斯激酶(JAKs)抑制活性的异恶唑衍生物 |
Country Status (2)
Country | Link |
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CN (1) | CN103896946B (zh) |
WO (1) | WO2014101295A2 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU24396B1 (es) | 2013-12-05 | 2019-04-04 | Pfizer | Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo |
KR101710127B1 (ko) * | 2014-08-29 | 2017-02-27 | 한화제약주식회사 | 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민 |
CN104530055A (zh) * | 2014-12-23 | 2015-04-22 | 南京艾德凯腾生物医药有限责任公司 | 枸橼酸托法替布的制备方法 |
CN105732637B (zh) * | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
CN104788461A (zh) * | 2015-04-30 | 2015-07-22 | 南京臣功制药股份有限公司 | 一种适合枸橼酸托法替尼工业化的生产方法 |
KR101771219B1 (ko) * | 2015-08-21 | 2017-09-05 | 양지화학 주식회사 | 야누스 키나제 1 선택적 억제제 및 그 의약 용도 |
CN107098908B (zh) * | 2016-02-23 | 2021-01-08 | 欣凯医药科技(上海)有限公司 | 一种吡咯并嘧啶类化合物的制备方法和应用 |
KR20170101724A (ko) * | 2016-02-29 | 2017-09-06 | 양지화학 주식회사 | 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민의 용도 |
TW201825458A (zh) * | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
CR20240101A (es) | 2018-03-08 | 2024-05-24 | Incyte Corp | COMPUESTOS DIÓLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-y (DIVISIONAL 2020-464) |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006069080A2 (en) * | 2004-12-22 | 2006-06-29 | Incyte Corporation | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2m3-b]pyrimidin-4-yl-amines as janus kinase inhibitors |
WO2010020905A1 (en) * | 2008-08-20 | 2010-02-25 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
WO2011045702A1 (en) * | 2009-10-15 | 2011-04-21 | Pfizer Inc. | Pyrrolo[2,3-d] pyrimidine compounds |
WO2011097087A1 (en) * | 2010-02-05 | 2011-08-11 | Pfizer Inc. | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors |
WO2013173506A2 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
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2012
- 2012-12-28 CN CN201210579810.8A patent/CN103896946B/zh active Active
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2013
- 2013-12-26 WO PCT/CN2013/001648 patent/WO2014101295A2/zh active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006069080A2 (en) * | 2004-12-22 | 2006-06-29 | Incyte Corporation | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2m3-b]pyrimidin-4-yl-amines as janus kinase inhibitors |
WO2010020905A1 (en) * | 2008-08-20 | 2010-02-25 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
WO2011045702A1 (en) * | 2009-10-15 | 2011-04-21 | Pfizer Inc. | Pyrrolo[2,3-d] pyrimidine compounds |
WO2011097087A1 (en) * | 2010-02-05 | 2011-08-11 | Pfizer Inc. | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors |
WO2013173506A2 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
Also Published As
Publication number | Publication date |
---|---|
CN103896946B (zh) | 2018-04-03 |
WO2014101295A2 (zh) | 2014-07-03 |
CN103896946A (zh) | 2014-07-02 |
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