BR112014026910A8 - novo derivado de beta-alanina, seus sais farmaceuticamente aceitáveis, e composições farmacêuticas compreendendo o mesmo como ingrediente ativo. - Google Patents

novo derivado de beta-alanina, seus sais farmaceuticamente aceitáveis, e composições farmacêuticas compreendendo o mesmo como ingrediente ativo.

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Publication number
BR112014026910A8
BR112014026910A8 BR112014026910A BR112014026910A BR112014026910A8 BR 112014026910 A8 BR112014026910 A8 BR 112014026910A8 BR 112014026910 A BR112014026910 A BR 112014026910A BR 112014026910 A BR112014026910 A BR 112014026910A BR 112014026910 A8 BR112014026910 A8 BR 112014026910A8
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salts
pharmaceutical compositions
active ingredient
alanine derivative
Prior art date
Application number
BR112014026910A
Other languages
English (en)
Other versions
BR112014026910A2 (pt
Inventor
Jung Kwak Hyun
Hee Ahn Jin
Sook Song Jin
Young Kim Ki
Kim Kwang-Rok
Bae Myung-Ae
H S Pagire
Dal Rhee Sang
Hoon Jung Won
Original Assignee
Handok Pharmaceuticals Co Ltd
Korea Res Inst Chemical Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Handok Pharmaceuticals Co Ltd, Korea Res Inst Chemical Tech filed Critical Handok Pharmaceuticals Co Ltd
Publication of BR112014026910A2 publication Critical patent/BR112014026910A2/pt
Publication of BR112014026910A8 publication Critical patent/BR112014026910A8/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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Abstract

resumo novo derivado de beta-alanina, seus sais farmaceuticamente aceitáveis, e composições farmacêuticas compreendendo o mesmo como ingrediente ativo a presente invenção refere-se a um derivado da beta-alanina, sais farmaceuticamente aceitáveis, e uma composição farmacêutica incluindo o mesmo como um ingrediente ativo. os derivados e sais farmaceuticamente aceitáveis dos novos beta-alanina de acordo com a presente invenção pode eficazmente inibir a atividade de dgat1, que é uma enzima que serve como um catalisador, na etapa final da síntese de lípidos neutros, para desse modo ser eficazmente utilizado como uma composição farmacêutica para a prevenção ou tratamento de vários distúrbios relacionados com o metabolismo de lípidos selecionados a partir do grupo consistindo de obesidade, dislipidemia, fígado gordo, síndroma de resistência à insulina, e hepatite.
BR112014026910A 2012-04-25 2013-04-25 novo derivado de beta-alanina, seus sais farmaceuticamente aceitáveis, e composições farmacêuticas compreendendo o mesmo como ingrediente ativo. BR112014026910A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20120043189 2012-04-25
KR1020130045811A KR101472279B1 (ko) 2012-04-25 2013-04-25 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물
PCT/KR2013/003557 WO2013162298A1 (ko) 2012-04-25 2013-04-25 신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제학적 조성물

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BR112014026910A2 BR112014026910A2 (pt) 2017-06-27
BR112014026910A8 true BR112014026910A8 (pt) 2018-01-09

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US (1) US9321728B2 (pt)
EP (1) EP2842938A4 (pt)
JP (1) JP2015520136A (pt)
KR (1) KR101472279B1 (pt)
CN (1) CN104254519B (pt)
BR (1) BR112014026910A8 (pt)
CA (1) CA2870886A1 (pt)
IN (1) IN2014MN02135A (pt)
MX (1) MX2014012937A (pt)
RU (1) RU2014147220A (pt)
WO (1) WO2013162298A1 (pt)

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WO2017151786A1 (en) 2016-03-01 2017-09-08 University Of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
CN115246774A (zh) * 2021-04-27 2022-10-28 南昌弘益科技有限公司 一类新型双羰基类阿魏酸衍生物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69824037T2 (de) * 1997-11-24 2005-06-02 Merck & Co., Inc. Beta-alanin-derivate als zell-adhäsions-inhibitoren
JP4261639B2 (ja) * 1998-08-05 2009-04-30 日本曹達株式会社 フェニルイミダゾール系抗高脂血症薬
JP2003128639A (ja) * 2001-10-25 2003-05-08 Sankyo Co Ltd ベンツアミド誘導体
EP1533294A4 (en) 2002-05-28 2007-07-04 Ono Pharmaceutical Co BETA-ALANINE DERIVATIVE AND USE THEREOF
EP2120911A1 (en) * 2007-02-15 2009-11-25 Prosidion Limited Amide and urea derivatives for the treatment of metabolic diseases
US20090036425A1 (en) * 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
WO2010122968A1 (ja) * 2009-04-21 2010-10-28 アステラス製薬株式会社 ジアシルエチレンジアミン化合物
MA34097B1 (fr) * 2010-03-30 2013-03-05 Novartis Ag Utilisations d'inhibiteurs de dgat1

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CA2870886A1 (en) 2013-10-31
WO2013162298A1 (ko) 2013-10-31
EP2842938A1 (en) 2015-03-04
IN2014MN02135A (pt) 2015-09-04
JP2015520136A (ja) 2015-07-16
RU2014147220A (ru) 2016-06-10
MX2014012937A (es) 2015-05-11
US20150329504A1 (en) 2015-11-19
US9321728B2 (en) 2016-04-26
BR112014026910A2 (pt) 2017-06-27
CN104254519A (zh) 2014-12-31
KR101472279B1 (ko) 2014-12-16
EP2842938A4 (en) 2015-12-23
KR20130120414A (ko) 2013-11-04
CN104254519B (zh) 2016-04-20
WO2013162298A8 (ko) 2013-12-27

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