CN104248703A - Traditional Chinese medicine composition for treating mycoplasma gallisepticum infection - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating mycoplasma gallisepticum infection. The composition consists of honeysuckle, forsythia, bupleurum root, folium isatidis, radix scutellariae, bulbus fritillariae cirrhosae and peppermint oil. Clinical tests prove that the composition can effectively treat chicken runny nose, fever, cough, asthma, dry and wet rales, bloody mucus caused by coughs, loss of appetite, lethargy, eye closure and other symptoms.

Description

A kind of Chinese medicine composition being used for the treatment of mycoplasma gallisepticam infection

Technical field

The present invention relates to a kind of removing summer-heat removing toxic substances, treatment mycoplasma gallisepticam infection, and the Chinese medicine composition of energy enhancing human body immunity power.

Background technology

Mycoplasma gallisepticam infection is popular in whole world chicken house, especially general at home.Primary disease mainly betides 1-2 monthly age chickling, the easier happening and prevelence of the chicken house that, density large in the number of animals raised is high.

The modal symptom of mycoplasma gallisepticam infection is respiratory symptom, and main manifestations is cough, sneeze, tracheal rale and rhinitis.The change of respiratory tract also weight differs.Slight not easily discovers, and occurs many viscous liquids or Catarrhal secretions in nostril, nasal sinuses, trachea and lung, and tracheal wall is edema slightly.Along with the development infected, air bag is muddy gradually, airbag wall occurs cheese shape exudate, as pearl during beginning, and in bulk in heaps time serious.Under socket of the eye there is inflammation in hole, Dou Chengxian viscosity and cheese shape exudate under chicken socket of the eye.Sometimes there is pericarditis and perihepatitis change.When there is joint symptoms, arthroncus edema, the survival rate of infected chicken declines, and live-weight reduces, or causes the great outburst of other diseases.This disease is very general at chicken house, has a strong impact on the economic benefit of chicken house.Current domesticly mainly have inhibiting antibiotic to treat with some to viral mycoplasma, no matter drinking-water or feedstuff are mixed clothes and all will be used in conjunction several days, due to antibiotic a large amount of use, the operating cost of chicken house is caused to strengthen, and easily form antibiotic abuse, thus the antibacterial in chicken body is caused to produce drug resistance.

Disclose the pharmaceutical composition of mycoplasma gallisepticam infection for such situation the present invention, composition of medicine is become with Herba Menthae wet goods Chinese drug-treated group by Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, Folium Isatidis, Radix Scutellariae, Bulbus Fritillariae Cirrhosae.Prove through clinical trial, this prescription successful, has no side effect, and fragrant, refreshment, the immunity of chicken can be increased, in animal body drug residue free, can not drug resistance be produced, avoid the possibility of abuse, overcome the shortcoming that antibiotic self is intrinsic well, and cheap, large burden can not be caused to chicken house.

Summary of the invention

The object of this invention is to provide a kind of pharmaceutical composition for the treatment of chicken virus mycoplasma disease.

Described compositions comprises Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, Folium Isatidis, Radix Scutellariae, Bulbus Fritillariae Cirrhosae and Oleum menthae.

The consumption of described compositions is: Flos Lonicerae 6-15g, Fructus Forsythiae 6-15g, Radix Bupleuri 5-9g, Folium Isatidis 9-15g, Radix Scutellariae 3-9g, Bulbus Fritillariae Cirrhosae 3-10g and Oleum menthae 0.016-0.03g.

The consumption of described compositions is preferably: Flos Lonicerae 15g, Fructus Forsythiae 8g, Radix Bupleuri 6g, Folium Isatidis 12g, Radix Scutellariae 9g, Bulbus Fritillariae Cirrhosae 10g, Oleum menthae 0.016-0.03g.

Described compositions is completed by following preparation technology:

(1) take each component of compositions by recipe quantity, decoct with water twice, for the first time 8 times of water gagings, second time 6 times of water gagings, keep micro-at every turn and boil 2 hours after boiling, 200 mesh filter screens filter while hot.Merge twice filtrate, mixing, is concentrated into five times of composition quality, and adding ethanol to the concentration of ethanol is 30%, cold preservation 24 hours, and filter, filtrate recycling ethanol, is concentrated into every milliliter and is equivalent to crude drug in whole 1g;

(2) get above-mentioned solution, add 0.3% sodium benzoate, recipe quantity Oleum menthae, stir, subpackage and get final product.

Beneficial effect of the present invention:

This invention compatibility rationally, have no side effect, can immunity of organisms be improved, chicken viral mycoplasma infection can be treated well, and prepare simple, cheap on a large scale compared with the medicine used with present chicken house, drug residue free, there is good economic worth, can industrial application.

Detailed description of the invention:

Embodiment 1

Embodiment 2

Embodiment 3

Embodiment 4

Embodiment 5

Preparation method:

(1) taking Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, Folium Isatidis, Radix Scutellariae, Bulbus Fritillariae Cirrhosae by often organizing recipe quantity, decocting with water twice, for the first time 8 times of water gagings, second time 6 times of water gagings, keep micro-at every turn and boil 2 hours after boiling, 200 mesh filter screens filter while hot.Merge twice filtrate, mixing, is concentrated into five times of composition quality, and adding ethanol to the concentration of ethanol is 30%, cold preservation 24 hours, and filter, filtrate recycling ethanol, is concentrated into every milliliter and is equivalent to crude drug in whole 1g;

(2) get above-mentioned solution, add 0.3% sodium benzoate, recipe quantity Oleum menthae, stir, subpackage and get final product.

Embodiment 6 present composition is to the clinical trial of mycoplasma gallisepticam infection:

1. experiment material

Compositions, 10% tylosin tartrate soluble powder (self-control) of the proportions in 11 employing embodiments 1.

1.2 are diagnosed as and suffer from mycoplasma gallisepticam infection, and 60 chickens that symptom is close

2. method

Three components is divided into not number at random 60 chickens

(1) first group is positive controls, not drug administration.

(2) second groups is drug control group.10% tylosin tartrate soluble powder is added according to the ratio of 1: 200 in drinking-water.

(3) the 3rd groups is 20 chickens infected, the oral liquid made according to the ratio in embodiment 1.With water according to 1: 500 ratio mix and take.

Within second day, observe, chicken heating, asthma, the inappetence of first group, close blurred vision and to sleep serious symptom.The chicken heating of second group, the symptom of asthma alleviates but inappetence, close the symptom that blurred vision sleeps and have no alleviation.The chicken heating of the 3rd group, the symptom of asthma take a turn for the better to some extent, and eyes are expression slightly.

Within 3rd day, observe, the chicken heating of first group, asthma, inappetence, close exacerbation of symptoms that blurred vision sleeps and body weight also decline gradually even start to occur dead.But the symptom of the chicken of second group heating, asthma obviously alleviates and also starts the situation that a small amount of diet body weight also has decline.The chicken heating of the 3rd group, the symptom of asthma are clearly better and start a small amount of diet, the situation that body weight does not reduce.

Within 4th day, observe, the chicken heating of first group, asthma, inappetence, close the more serious and chicken of weight loss of symptom that blurred vision sleeps and start to increase, the phenomena of mortality also increase.The chicken heating of second group, the symptom of asthma lose alleviation and to increase the weight of to some extent on the contrary and chicken starts the listless phenomenon also having minority death.The chicken heating of the 3rd group, the symptom of asthma disappear substantially, and eyes have god and active active normal diet.The experimental result of above three groups sees the following form

Curative effect determinate standard

Cure rate: after off-test, the state of an illness, appetite, clinical symptoms are recovered normal morbidity completely and accounted for this group and always to fall ill the ratio of chicken.

Effective percentage: after off-test, the state of an illness, appetite, clinical symptoms take a turn for the better and the chicken that recovers to fall ill normally accounts for this group and always to fall ill the ratio of chicken to some extent.

Mortality rate: after in off-test or process of the test, the morbidity chicken died of illness because of chicken virus mycoplasma accounts for this group and always to fall ill the ratio of chicken.

Clinical verification test efficacy result

Drawn from upper table, traditional Chinese medicine composition for treating mycoplasma gallisepticam infection cure rate of the present invention, effective percentage are all apparently higher than drug control group.

Claims (4)

1. be used for the treatment of a pharmaceutical composition for mycoplasma gallisepticam infection, it is characterized in that, described compositions comprises Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, Folium Isatidis, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Oleum menthae.

2. a kind of pharmaceutical composition being used for the treatment of mycoplasma gallisepticam infection according to claim 1, is characterized in that the consumption of described compositions is: Flos Lonicerae 6-15g, Fructus Forsythiae 6-15g, Radix Bupleuri 5-9g, Folium Isatidis 9-15g, Radix Scutellariae 3-9g, Bulbus Fritillariae Cirrhosae 3-10g and Oleum menthae 0.016-0.03g.

3. a kind of pharmaceutical composition being used for the treatment of mycoplasma gallisepticam infection according to claim 2, is characterized in that the consumption of described compositions is: Flos Lonicerae 15g, Fructus Forsythiae 8g, Radix Bupleuri 6g, Folium Isatidis 12g, Radix Scutellariae 9g, Bulbus Fritillariae Cirrhosae 10g, Oleum menthae 0.016-0.03g.

4. be used for the treatment of a pharmaceutical composition for mycoplasma gallisepticam infection, it is characterized in that being completed by following preparation technology:

(1) take each component of compositions by recipe quantity, decoct with water twice, for the first time 8 times of water gagings, second time 6 times of water gagings, keep micro-at every turn and boil 2 hours after boiling, 200 mesh filter screens filter while hot.Merge twice filtrate, mixing, is concentrated into five times of composition quality, and adding ethanol to the concentration of ethanol is 30%, cold preservation 24 hours, and filter, filtrate recycling ethanol, is concentrated into every milliliter and is equivalent to crude drug in whole 1g;

(2) get above-mentioned solution, add 0.3% sodium benzoate, recipe quantity Oleum menthae, stir, subpackage and get final product.