CN104208713B - 用于热熔挤出的组合物以及用其制备热熔挤出产品的方法 - Google Patents
用于热熔挤出的组合物以及用其制备热熔挤出产品的方法 Download PDFInfo
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- CN104208713B CN104208713B CN201410242677.6A CN201410242677A CN104208713B CN 104208713 B CN104208713 B CN 104208713B CN 201410242677 A CN201410242677 A CN 201410242677A CN 104208713 B CN104208713 B CN 104208713B
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B13/00—Preparation of cellulose ether-esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/201—Pre-melted polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/32—Cellulose ether-esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2301/08—Cellulose derivatives
- C08J2301/32—Cellulose ether-esters
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| JP2013-116836 | 2013-06-03 | ||
| JP2013116836 | 2013-06-03 | ||
| JP2013-246178 | 2013-11-28 | ||
| JP2013246178 | 2013-11-28 |
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| CN104208713A CN104208713A (zh) | 2014-12-17 |
| CN104208713B true CN104208713B (zh) | 2018-04-27 |
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| CN201480030211.8A Active CN105283203B (zh) | 2013-06-03 | 2014-06-03 | 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 |
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| EP (2) | EP3006049B1 (https=) |
| JP (2) | JP6126555B2 (https=) |
| KR (2) | KR102228157B1 (https=) |
| CN (2) | CN104208713B (https=) |
| IN (1) | IN2014DE01467A (https=) |
| PT (2) | PT3006049T (https=) |
| WO (1) | WO2014196519A1 (https=) |
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| PT3006049T (pt) | 2013-06-03 | 2018-03-20 | Shinetsu Chemical Co | Composição para extrusão por fusão a quente e método para produzir um produto extrudido por fusão a quente |
| JP6203702B2 (ja) * | 2014-11-18 | 2017-09-27 | 信越化学工業株式会社 | ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法 |
| CA2970717A1 (en) | 2014-12-18 | 2016-06-23 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
| KR20180008524A (ko) * | 2015-05-15 | 2018-01-24 | 다우 글로벌 테크놀로지스 엘엘씨 | 초고분자량 및 저점도의 에스테르화된 셀룰로오스 에테르의 제조 방법 |
| BR112017023845A2 (pt) * | 2015-05-15 | 2018-07-31 | Dow Global Technologies Llc | processo de preparação de um éter de celulose esterificado de peso molecular elevado |
| BR112018001792A2 (pt) | 2015-07-28 | 2018-09-11 | Dow Global Technologies Llc | processo para produzir dispersão de éter de celulose esterificado |
| WO2018170083A1 (en) | 2017-03-17 | 2018-09-20 | Dow Global Technologies Llc | Process for recovering an esterified cellulose ether from a reaction product mixture |
| JP2020511572A (ja) | 2017-03-17 | 2020-04-16 | ダウ グローバル テクノロジーズ エルエルシー | 反応生成物混合物からのエステル化セルロースエーテルの回収方法 |
| CN110366566B (zh) | 2017-03-17 | 2021-08-13 | 陶氏环球技术有限责任公司 | 用于从反应产物混合物中回收酯化纤维素醚的方法 |
| US20180282527A1 (en) * | 2017-03-30 | 2018-10-04 | Shin-Etsu Chemical Co., Ltd. | Injection molding composition containing hypromellose acetate succinate and method for producing same |
| CN109078186B (zh) * | 2017-06-14 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种胃漂浮组合物及其制备方法 |
| TR201722852A2 (tr) * | 2017-12-29 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari |
| WO2020131801A1 (en) | 2018-12-18 | 2020-06-25 | DDP Specialty Electronic Materials US, Inc. | A sustained release composition comprising a hydroxypropyl methylcellulose acetate succinate |
| JP7050714B2 (ja) | 2019-04-04 | 2022-04-08 | 信越化学工業株式会社 | 腸溶性コーティング用組成物及び固形製剤の製造方法 |
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| JP2015127316A (ja) | 2015-07-09 |
| KR20140142173A (ko) | 2014-12-11 |
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| IN2014DE01467A (https=) | 2015-07-24 |
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| KR20160015234A (ko) | 2016-02-12 |
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| US10646573B2 (en) | 2020-05-12 |
| EP3006049B1 (en) | 2018-02-28 |
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| US10016508B2 (en) | 2018-07-10 |
| JP6126555B2 (ja) | 2017-05-10 |
| US20140357681A1 (en) | 2014-12-04 |
| CN105283203A (zh) | 2016-01-27 |
| EP2810660A1 (en) | 2014-12-10 |
| JPWO2014196519A1 (ja) | 2017-02-23 |
| EP2810660B1 (en) | 2017-07-26 |
| PT2810660T (pt) | 2017-08-16 |
| KR102228157B1 (ko) | 2021-03-17 |
| KR101918327B1 (ko) | 2018-11-13 |
| JP6007322B2 (ja) | 2016-10-12 |
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