KR102228157B1 - 가열 용융 압출용 조성물 및 이것을 사용한 가열 용융 압출 성형물의 제조 방법 - Google Patents

가열 용융 압출용 조성물 및 이것을 사용한 가열 용융 압출 성형물의 제조 방법 Download PDF

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KR102228157B1
KR102228157B1 KR1020157034116A KR20157034116A KR102228157B1 KR 102228157 B1 KR102228157 B1 KR 102228157B1 KR 1020157034116 A KR1020157034116 A KR 1020157034116A KR 20157034116 A KR20157034116 A KR 20157034116A KR 102228157 B1 KR102228157 B1 KR 102228157B1
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drug
acid ester
hpmcas
group
melt extrusion
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KR20160015234A (ko
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쇼고 와라시나
후미에 구사키
가즈키 기쿠치
사카에 오바라
나오스케 마루야마
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신에쓰 가가꾸 고교 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/201—Pre-melted polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/32—Cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/32—Cellulose ether-esters

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020157034116A 2013-06-03 2014-06-03 가열 용융 압출용 조성물 및 이것을 사용한 가열 용융 압출 성형물의 제조 방법 Active KR102228157B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPJP-P-2013-116836 2013-06-03
JP2013116836 2013-06-03
JPJP-P-2013-246178 2013-11-28
JP2013246178 2013-11-28
PCT/JP2014/064711 WO2014196519A1 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Publications (2)

Publication Number Publication Date
KR20160015234A KR20160015234A (ko) 2016-02-12
KR102228157B1 true KR102228157B1 (ko) 2021-03-17

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ID=50842156

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KR1020157034116A Active KR102228157B1 (ko) 2013-06-03 2014-06-03 가열 용융 압출용 조성물 및 이것을 사용한 가열 용융 압출 성형물의 제조 방법
KR1020140067370A Active KR101918327B1 (ko) 2013-06-03 2014-06-03 가열 용융 압출용 조성물 및 이를 이용한 가열 용융 압출 성형물의 제조 방법

Family Applications After (1)

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KR1020140067370A Active KR101918327B1 (ko) 2013-06-03 2014-06-03 가열 용융 압출용 조성물 및 이를 이용한 가열 용융 압출 성형물의 제조 방법

Country Status (8)

Country Link
US (2) US10646573B2 (https=)
EP (2) EP3006049B1 (https=)
JP (2) JP6126555B2 (https=)
KR (2) KR102228157B1 (https=)
CN (2) CN104208713B (https=)
IN (1) IN2014DE01467A (https=)
PT (2) PT3006049T (https=)
WO (1) WO2014196519A1 (https=)

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Also Published As

Publication number Publication date
WO2014196519A1 (ja) 2014-12-11
JP2015127316A (ja) 2015-07-09
KR20140142173A (ko) 2014-12-11
US20160095928A1 (en) 2016-04-07
IN2014DE01467A (https=) 2015-07-24
CN104208713A (zh) 2014-12-17
PT3006049T (pt) 2018-03-20
CN105283203B (zh) 2018-12-28
KR20160015234A (ko) 2016-02-12
EP3006049A4 (en) 2017-02-22
US10646573B2 (en) 2020-05-12
EP3006049B1 (en) 2018-02-28
CN104208713B (zh) 2018-04-27
EP3006049A1 (en) 2016-04-13
US10016508B2 (en) 2018-07-10
JP6126555B2 (ja) 2017-05-10
US20140357681A1 (en) 2014-12-04
CN105283203A (zh) 2016-01-27
EP2810660A1 (en) 2014-12-10
JPWO2014196519A1 (ja) 2017-02-23
EP2810660B1 (en) 2017-07-26
PT2810660T (pt) 2017-08-16
KR101918327B1 (ko) 2018-11-13
JP6007322B2 (ja) 2016-10-12

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