CN104203977A - 结合肽聚糖识别蛋白1的抗体 - Google Patents

结合肽聚糖识别蛋白1的抗体 Download PDF

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Publication number
CN104203977A
CN104203977A CN201280069905.3A CN201280069905A CN104203977A CN 104203977 A CN104203977 A CN 104203977A CN 201280069905 A CN201280069905 A CN 201280069905A CN 104203977 A CN104203977 A CN 104203977A
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CN
China
Prior art keywords
amino
pglyrp1
antibody
trem
seq
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Pending
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CN201280069905.3A
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English (en)
Chinese (zh)
Inventor
V.W.斯坦尼科
C.B.里德
J.奎珀
X.唐
M.海佩
S.A.乔斯
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Novo Nordisk AS
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Novo Nordisk AS
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Priority to CN201810257792.9A priority Critical patent/CN108530535B/zh
Publication of CN104203977A publication Critical patent/CN104203977A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280069905.3A 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体 Pending CN104203977A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810257792.9A CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261598968P 2012-02-15 2012-02-15
US61/598968 2012-02-15
EP12158974.1 2012-03-12
EP12158974 2012-03-12
US201261672799P 2012-07-18 2012-07-18
US61/672799 2012-07-18
PCT/EP2012/074093 WO2013120554A1 (en) 2012-02-15 2012-11-30 Antibodies that bind peptidoglycan recognition protein 1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810257792.9A Division CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

Publications (1)

Publication Number Publication Date
CN104203977A true CN104203977A (zh) 2014-12-10

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CN201280069905.3A Pending CN104203977A (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体
CN201810257792.9A Active CN108530535B (zh) 2012-02-15 2012-11-30 结合肽聚糖识别蛋白1的抗体

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Country Status (13)

Country Link
US (3) US9663568B2 (https=)
EP (2) EP2814842B1 (https=)
JP (1) JP6400480B2 (https=)
CN (2) CN104203977A (https=)
DK (1) DK2814842T3 (https=)
ES (1) ES2690786T3 (https=)
HR (1) HRP20181817T1 (https=)
LT (1) LT2814842T (https=)
PL (1) PL2814842T3 (https=)
RS (1) RS57827B1 (https=)
SI (1) SI2814842T1 (https=)
SM (1) SMT201800620T1 (https=)
WO (1) WO2013120554A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106672A (zh) * 2015-01-12 2017-08-29 新加坡科技研究局 用于预防和治疗免疫介导性疾病的针对胞壁酰肽的单克隆抗体
CN107417773A (zh) * 2016-05-30 2017-12-01 国盛生化股份有限公司 新颖黏合细胞壁之胜肽序列
WO2025007943A1 (zh) * 2023-07-06 2025-01-09 荣昌生物制药(烟台)股份有限公司 用taci-fc融合蛋白治疗anca相关性血管炎的方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6400480B2 (ja) 2012-02-15 2018-10-03 ノヴォ ノルディスク アー／エス ペプチドグリカン認識タンパク質１に結合する抗体
CN103484468B (zh) * 2013-09-11 2015-04-08 华南农业大学 一种小菜蛾肽聚糖识别蛋白及其制备方法与应用
US11213598B2 (en) * 2015-11-12 2022-01-04 The Board Of Trustees Of The Leland Stanford Junior University Labeled probe and methods of use
WO2019032624A1 (en) * 2017-08-08 2019-02-14 Pionyr Immunotherapeutics, Inc. COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
CN109879956A (zh) * 2019-03-04 2019-06-14 哈尔滨工业大学 一种肿瘤免疫生物标志物及其应用
CN118307672B (zh) * 2021-07-14 2026-04-17 浙江大学 一种抗人MICA/B α3区的抗体及其应用
CN115873109B (zh) * 2022-05-16 2024-02-09 江苏省中国科学院植物研究所 单克隆抗体及其在制备用于预防/治疗神经系统退行性疾病的生物制品中的应用
WO2025042607A1 (en) * 2023-08-18 2025-02-27 The Brigham And Women's Hospital, Inc. Modulation of pglyrp1 for treatment of cancer and autoimmunity
CN119286795B (zh) * 2024-12-12 2025-02-25 天津一瑞生物科技股份有限公司 鼠抗革兰阳性菌肽聚糖杂交瘤细胞株,单克隆抗体和应用
CN120718152B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种特异性结合pglyrp1的单克隆抗体及其制备方法和应用
CN120737202B (zh) * 2025-09-01 2025-11-14 北京大学口腔医学院 一种抗pglyrp1抗体及其制备方法和应用
CN120737201B (zh) * 2025-09-01 2025-11-18 北京大学口腔医学院 一种靶向pglyrp1的单克隆抗体及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101139599A (zh) * 2007-08-07 2008-03-12 西南大学 家蚕肽聚糖识别蛋白基因
CN101619102A (zh) * 2008-12-16 2010-01-06 中国科学院海洋研究所 一种具杀菌活性的栉孔扇贝肽聚糖识别蛋白的制备及应用

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