CN104151275B - 炎琥宁化合物的制备方法 - Google Patents
炎琥宁化合物的制备方法 Download PDFInfo
- Publication number
- CN104151275B CN104151275B CN201410441239.2A CN201410441239A CN104151275B CN 104151275 B CN104151275 B CN 104151275B CN 201410441239 A CN201410441239 A CN 201410441239A CN 104151275 B CN104151275 B CN 104151275B
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- CN
- China
- Prior art keywords
- acid
- sodium salt
- organic solvent
- andrographolide
- dehydroandrographolide succinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410441239.2A CN104151275B (zh) | 2014-09-01 | 2014-09-01 | 炎琥宁化合物的制备方法 |
Applications Claiming Priority (1)
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CN201410441239.2A CN104151275B (zh) | 2014-09-01 | 2014-09-01 | 炎琥宁化合物的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104151275A CN104151275A (zh) | 2014-11-19 |
CN104151275B true CN104151275B (zh) | 2016-09-07 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410441239.2A Active CN104151275B (zh) | 2014-09-01 | 2014-09-01 | 炎琥宁化合物的制备方法 |
Country Status (1)
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CN (1) | CN104151275B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104744412A (zh) * | 2015-04-07 | 2015-07-01 | 重庆药友制药有限责任公司 | 一种炎琥宁化合物 |
CN108658905B (zh) * | 2018-04-25 | 2023-02-14 | 四川子仁制药有限公司 | 一种用于降低炎琥宁原料药成品中有关物质的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102382082A (zh) * | 2011-09-07 | 2012-03-21 | 周晓东 | 一种新的炎琥宁化合物及其药物组合物 |
CN102603684A (zh) * | 2012-01-19 | 2012-07-25 | 黑龙江珍宝岛药业股份有限公司 | 一种无菌炎琥宁及其制备方法 |
CN102617527A (zh) * | 2012-03-01 | 2012-08-01 | 湖北荷普药业股份有限公司 | 穿琥宁或炎琥宁的制备方法 |
CN103113330A (zh) * | 2013-02-28 | 2013-05-22 | 成都倍特药业有限公司 | 炎琥宁成盐工艺 |
-
2014
- 2014-09-01 CN CN201410441239.2A patent/CN104151275B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102382082A (zh) * | 2011-09-07 | 2012-03-21 | 周晓东 | 一种新的炎琥宁化合物及其药物组合物 |
CN102603684A (zh) * | 2012-01-19 | 2012-07-25 | 黑龙江珍宝岛药业股份有限公司 | 一种无菌炎琥宁及其制备方法 |
CN102617527A (zh) * | 2012-03-01 | 2012-08-01 | 湖北荷普药业股份有限公司 | 穿琥宁或炎琥宁的制备方法 |
CN103113330A (zh) * | 2013-02-28 | 2013-05-22 | 成都倍特药业有限公司 | 炎琥宁成盐工艺 |
Non-Patent Citations (1)
Title |
---|
炎琥宁的合成工艺研究;柏俊 等;《药物研究》;20071231;第16卷(第24期);第21页 * |
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Publication number | Publication date |
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CN104151275A (zh) | 2014-11-19 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 256100 No. 6 Erlang Road, Yiyuan County, Zibo, Shandong Patentee after: Ruiyang Pharmaceutical Co.,Ltd. Address before: 256100 No. 6 Erlang Road, Yiyuan County, Zibo, Shandong Patentee before: REYOUNG PHARMACEUTICAL Co.,Ltd. |
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CP01 | Change in the name or title of a patent holder | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of Yanhuning compound Effective date of registration: 20211209 Granted publication date: 20160907 Pledgee: Commercial Bank of China Yiyuan branch of Limited by Share Ltd. Pledgor: Ruiyang Pharmaceutical Co.,Ltd. Registration number: Y2021980014543 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221012 Granted publication date: 20160907 Pledgee: Commercial Bank of China Yiyuan branch of Limited by Share Ltd. Pledgor: Ruiyang Pharmaceutical Co.,Ltd. Registration number: Y2021980014543 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |