CN104145024A - 用于早期结直肠癌检测的血浆微小rna - Google Patents

用于早期结直肠癌检测的血浆微小rna Download PDF

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Publication number
CN104145024A
CN104145024A CN201280064096.7A CN201280064096A CN104145024A CN 104145024 A CN104145024 A CN 104145024A CN 201280064096 A CN201280064096 A CN 201280064096A CN 104145024 A CN104145024 A CN 104145024A
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mir
hsa
colorectal
micrornas
expression
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梅瑞特谢尔·卡斯·吉诺内拉
荷西·胡安·罗扎诺萨瓦特拉
安东尼·嘎拉贡·卡斯特
多洛莉丝·玛利亚·吉拉尔德兹
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Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBEREHD
Hospital Clinic de Barcelona
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Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBEREHD
Hospital Clinic de Barcelona
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Priority to CN201510098369.5A priority Critical patent/CN104651521B/zh
Publication of CN104145024A publication Critical patent/CN104145024A/zh
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CN201280064096.7A 2011-10-21 2012-10-20 用于早期结直肠癌检测的血浆微小rna Pending CN104145024A (zh)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104313142A (zh) * 2014-10-16 2015-01-28 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104372004A (zh) * 2014-12-04 2015-02-25 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
CN107236799A (zh) * 2017-06-15 2017-10-10 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107254522A (zh) * 2017-06-09 2017-10-17 中山大学附属第三医院 miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用
CN107326092A (zh) * 2017-08-25 2017-11-07 深圳市恩普电子技术有限公司 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒
CN107746886A (zh) * 2017-09-11 2018-03-02 朱伟 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用
CN109557311A (zh) * 2018-12-13 2019-04-02 中南大学湘雅医院 结直肠癌诊断标志物及结直肠癌的检测产品及其应用
CN110139936A (zh) * 2016-08-18 2019-08-16 N·特兰 口腔癌、咽癌和喉癌的生物标记
CN110205367A (zh) * 2018-02-28 2019-09-06 伽蓝（集团）股份有限公司 一种筛选保护皮肤细胞端粒的活性物的方法
CN113981096A (zh) * 2021-11-30 2022-01-28 无锡市疾病预防控制中心 一种用于诊断结直肠癌的血浆miRNA标志物及其应用
CN114672560A (zh) * 2022-01-12 2022-06-28 北京艾克伦医疗科技有限公司 通过外泌体miRNA标志物鉴定结直肠癌状态的检测试剂盒和方法
CN116064801A (zh) * 2015-03-09 2023-05-05 新加坡科技研究局 通过检测微小RNA(miRNA)的表达水平来确定患乳腺癌的风险的方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0309214A3 (en) 1987-09-22 1990-03-14 BAXTER INTERNATIONAL INC. (a Delaware corporation) Fiber optical probe connector for physiologic measurement devices
EP2668295A4 (en) 2011-01-26 2016-01-13 Cepheid METHODS OF DETECTING LUNG CANCER
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
ES2906714T3 (es) 2012-09-04 2022-04-20 Guardant Health Inc Métodos para detectar mutaciones raras y variación en el número de copias
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
ES2784450T3 (es) 2013-12-28 2020-09-25 Guardant Health Inc Métodos y sistemas para detectar variantes genéticas
EP3108012A4 (en) 2014-02-18 2017-10-11 Baylor Research Institute Mir-320e and colorectal cancer
RU2017100884A (ru) 2014-06-13 2018-07-18 Торэй Индастриз, Инк. Набор или устройство для обнаружения рака ободочной и прямой кишки и способ обнаружения
WO2016034715A2 (fr) * 2014-09-05 2016-03-10 Prestizia Methode de prediction de l'evolution clinique du cancer colorectal
CN104388541B (zh) * 2014-10-21 2017-07-04 复旦大学附属肿瘤医院 miR‑1914*和miR‑1915的用途
EP3147370A1 (en) * 2015-09-28 2017-03-29 Rheinische Friedrich-Wilhelms-Universität Bonn Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat)
CA3008651A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
EP3327135A1 (en) * 2016-11-28 2018-05-30 Advanced Marker Discovery, S.L. In vitro method for identifying colorectal adenomas or colorectal cancer
CN106950370A (zh) * 2017-01-25 2017-07-14 上海市第十人民医院 血液微小核酸大肠癌诊断分子组合
WO2019144183A1 (en) * 2018-01-23 2019-08-01 La Trobe University Biomarkers of colorectal cancer
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
CN112512440B (zh) * 2018-05-09 2024-07-09 德玛泰克公司 新型基因分类器及其在自身免疫性疾病中的用途
CN108753974B (zh) * 2018-06-27 2022-05-06 深圳华大生命科学研究院 一种结直肠癌肿瘤标志物及其检测方法与装置
KR102275465B1 (ko) * 2019-01-18 2021-07-09 사회복지법인 삼성생명공익재단 전이성 대장암 치료물질 스크리닝 방법
CN112041463B (zh) * 2019-03-11 2024-07-23 香港中文大学 结肠直肠癌的miRNA标志物
WO2021009184A1 (en) * 2019-07-15 2021-01-21 Institut D'investigacions Biomèdiques August Pi I Sunyer (Idibaps) Non-invasive method for the diagnosis or screening of colorectal cancer and/or pre-cancerous stage thereof
CN110438227A (zh) * 2019-07-29 2019-11-12 广州中昱医学生物科技有限公司 miR-17-92在结直肠癌诊断中的用途
CN112080568A (zh) * 2020-09-27 2020-12-15 扬州大学 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用
JP7740733B2 (ja) * 2021-08-31 2025-09-17 国立大学法人大阪大学 ２型糖尿病・大腸がんを検査する方法
US20230083456A1 (en) * 2021-09-08 2023-03-16 GeneGenieDx Corporation Compositions and methods for diagnosing colorectal cancer
US20250197946A1 (en) 2022-05-20 2025-06-19 Novigenix Sa Biomarkers for colorectal neoplasia
CN119144728B (zh) * 2024-11-19 2025-04-29 四川大学华西医院 原发性肝癌的MicroRNA标志物的引物、试剂盒和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011076142A1 (en) * 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of colorectal cancer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB0415277D0 (en) * 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7939255B2 (en) 2006-07-03 2011-05-10 Catholic University Industry Academy Cooperation Foundation Diagnostic methods for colorectal cancer
US8343719B2 (en) * 2006-10-30 2013-01-01 Research Foundation Of State University Of New York Microrna as biomarker in cancer
CA2667617A1 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
CA2703986A1 (en) * 2007-10-30 2009-05-07 Veridex, Llc Process for monitoring colorectal cancer
CN101424640B (zh) * 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
US20090233297A1 (en) * 2008-03-06 2009-09-17 Elizabeth Mambo Microrna markers for recurrence of colorectal cancer
WO2009140670A2 (en) * 2008-05-16 2009-11-19 Veridex, Llc Methods for assessing colorectal cancer and compositions for use therein
WO2010004562A2 (en) 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
GB2463401B (en) * 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
CN102439169B (zh) * 2008-11-13 2014-11-19 复旦大学 用于结肠直肠癌的微rna表达谱分析的组合物和方法
WO2010126355A1 (en) * 2009-04-29 2010-11-04 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for counteracting, preventing and/or determining heart failure, or a risk of heart failure
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases
US20100317533A1 (en) 2009-06-05 2010-12-16 British Columbia Cancer Agency Branch Biomarkers of cancer metastasis
WO2011012136A1 (en) 2009-07-28 2011-02-03 Exiqon A/S A method for classifying a human cell sample as cancerous
CN101988060A (zh) * 2009-07-30 2011-03-23 江苏命码生物科技有限公司 结直肠癌检测标记物及其检测方法、试剂盒和生物芯片
US8956817B2 (en) * 2009-10-09 2015-02-17 Baylor Research Institute Identification of microRNAs (miRNAs) in fecal samples as biomarkers for gastroenterological cancers
WO2011076147A1 (en) 2009-12-24 2011-06-30 Fudan University Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer
EP2524059A4 (en) 2010-01-13 2013-11-20 Caris Life Sciences Luxembourg Holdings DETECTION OF GASTROINTESTINAL DISEASES
WO2011160585A1 (en) * 2010-06-23 2011-12-29 The Chinese University Of Hong Kong Micro-rna markers for colorectal cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011076142A1 (en) * 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of colorectal cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SYLVAIN PRADERVAND ET.AL.,: ""Concordance among digital gene expression,microarrays, and qPCRwhen measuring differential expression of microRNAs"", 《BIOTECHNIQUES》 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104313142B (zh) * 2014-10-16 2016-02-03 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104313142A (zh) * 2014-10-16 2015-01-28 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104372004A (zh) * 2014-12-04 2015-02-25 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
CN116064801A (zh) * 2015-03-09 2023-05-05 新加坡科技研究局 通过检测微小RNA(miRNA)的表达水平来确定患乳腺癌的风险的方法
CN110139936A (zh) * 2016-08-18 2019-08-16 N·特兰 口腔癌、咽癌和喉癌的生物标记
CN107254522A (zh) * 2017-06-09 2017-10-17 中山大学附属第三医院 miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用
CN107236799B (zh) * 2017-06-15 2020-06-09 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107236799A (zh) * 2017-06-15 2017-10-10 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107326092A (zh) * 2017-08-25 2017-11-07 深圳市恩普电子技术有限公司 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒
CN107326092B (zh) * 2017-08-25 2021-07-20 深圳市恩普电子技术有限公司 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒
CN107746886A (zh) * 2017-09-11 2018-03-02 朱伟 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用
CN110205367A (zh) * 2018-02-28 2019-09-06 伽蓝（集团）股份有限公司 一种筛选保护皮肤细胞端粒的活性物的方法
CN110205367B (zh) * 2018-02-28 2022-06-21 伽蓝（集团）股份有限公司 一种筛选保护皮肤细胞端粒的活性物的方法
CN109557311A (zh) * 2018-12-13 2019-04-02 中南大学湘雅医院 结直肠癌诊断标志物及结直肠癌的检测产品及其应用
CN113981096A (zh) * 2021-11-30 2022-01-28 无锡市疾病预防控制中心 一种用于诊断结直肠癌的血浆miRNA标志物及其应用
CN114672560A (zh) * 2022-01-12 2022-06-28 北京艾克伦医疗科技有限公司 通过外泌体miRNA标志物鉴定结直肠癌状态的检测试剂盒和方法

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