CN104140418B - 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 - Google Patents
2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 Download PDFInfo
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- CN104140418B CN104140418B CN201410401604.7A CN201410401604A CN104140418B CN 104140418 B CN104140418 B CN 104140418B CN 201410401604 A CN201410401604 A CN 201410401604A CN 104140418 B CN104140418 B CN 104140418B
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- methyl
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- pyrimidine
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Pulmonology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410401604.7A CN104140418B (zh) | 2014-08-15 | 2014-08-15 | 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 |
| JP2017527959A JP6418622B2 (ja) | 2014-08-15 | 2015-07-31 | ２−（２，４，５−置換アニリン）ピリミジン誘導体、その薬物組成物及びその用途 |
| PCT/CN2015/085714 WO2016023422A1 (zh) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-取代苯胺)嘧啶衍生物、其药物组合物及其用途 |
| EP15832588.6A EP3181559B8 (en) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof |
| AU2015303641A AU2015303641B2 (en) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof |
| CA2958095A CA2958095C (en) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof |
| US15/553,892 US10414756B2 (en) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof |
| KR1020177007190A KR101937704B1 (ko) | 2014-08-15 | 2015-07-31 | 2-(2,4,5-치환 아닐린)피리미딘 유도체, 이의 약물 조성물 및 이의 용도 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410401604.7A CN104140418B (zh) | 2014-08-15 | 2014-08-15 | 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 |
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| Publication Number | Publication Date |
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| CN104140418A CN104140418A (zh) | 2014-11-12 |
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| EP (1) | EP3181559B8 (https=) |
| JP (1) | JP6418622B2 (https=) |
| KR (1) | KR101937704B1 (https=) |
| CN (1) | CN104140418B (https=) |
| AU (1) | AU2015303641B2 (https=) |
| CA (1) | CA2958095C (https=) |
| WO (1) | WO2016023422A1 (https=) |
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| CN104140418B (zh) * | 2014-08-15 | 2016-08-24 | 常州润诺生物科技有限公司 | 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 |
| CN105237515B (zh) * | 2014-10-10 | 2018-06-05 | 益方生物科技（上海）有限公司 | 氘代嘧啶类化合物、其制备方法、药物组合物和用途 |
| WO2016054987A1 (zh) * | 2014-10-11 | 2016-04-14 | 上海翰森生物医药科技有限公司 | Egfr抑制剂及其制备和应用 |
| CN105085489B (zh) * | 2014-11-05 | 2019-03-01 | 益方生物科技（上海）有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| CN105712998B (zh) * | 2014-12-05 | 2019-12-13 | 上海润诺生物科技有限公司 | 氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| CN105001208A (zh) * | 2015-08-06 | 2015-10-28 | 南京雷科星生物技术有限公司 | 一种表皮生长因子受体egfr抑制剂及其制备方法与用途 |
| CN105153122B (zh) * | 2015-08-27 | 2018-07-20 | 上海圣考医药科技有限公司 | [(吲哚-3-基)嘧啶-2-基]氨基苯基丙-2-烯酰胺衍生物及盐、制备方法、应用 |
| WO2017035753A1 (zh) * | 2015-08-31 | 2017-03-09 | 无锡双良生物科技有限公司 | 2-芳胺基吡啶、嘧啶或三嗪衍生物及其制备方法和用途 |
| CN106478605A (zh) * | 2015-09-02 | 2017-03-08 | 上海页岩科技有限公司 | 嘧啶类化合物、其制备方法和医药用途 |
| CA3009850C (en) * | 2015-12-27 | 2020-05-26 | NeuForm Pharmaceuticals, Inc. | Deuterated compounds for treating cancer and related diseases and conditions, and compositions and methods thereof |
| CN108610331A (zh) * | 2016-01-22 | 2018-10-02 | 焦玉奇 | 2-(2,4,5-取代苯胺)嘧啶衍生物 |
| CN107043369A (zh) * | 2016-02-06 | 2017-08-15 | 焦玉奇 | 2‑(2,4,5‑取代苯胺)嘧啶衍生物 |
| CN112645932B (zh) * | 2016-03-22 | 2022-01-14 | 江苏豪森药业集团有限公司 | Egfr抑制剂游离碱或其酸式盐的多晶型、其制备方法和应用 |
| MX383920B (es) | 2016-05-26 | 2025-03-14 | Recurium Ip Holdings Llc | Compuestos inhibidores de egfr. |
| WO2018050108A1 (zh) * | 2016-09-19 | 2018-03-22 | 江苏正大丰海制药有限公司 | 氘代3-(4,5-取代氨基嘧啶)苯基衍生物及其应用 |
| CN108129342A (zh) * | 2016-11-30 | 2018-06-08 | 浙江九洲药物科技有限公司 | 一种奥希替尼中间体及其制备方法 |
| CN108047205B (zh) * | 2016-12-14 | 2019-08-27 | 河南真实生物科技有限公司 | 2-(2，4，5-取代苯氨基)嘧啶衍生物、其制备方法及其在制备抗肿瘤药物中的应用 |
| CN106957304B (zh) * | 2017-04-25 | 2017-12-01 | 孔令廷 | 一种石墨烯负载FeCl3催化剂的制备方法及其在制备抗癌药物中间体的用途 |
| CN107192773B (zh) * | 2017-05-17 | 2019-09-27 | 张家港威胜生物医药有限公司 | 一种检测奥希替尼含量和有关物质的高效液相法 |
| CN108929311B (zh) * | 2017-05-22 | 2020-07-28 | 焦玉奇 | 2-(2,4,5-取代苯胺)嘧啶衍生物 |
| ES2956943T3 (es) | 2017-05-24 | 2024-01-05 | Tyk Medicines Inc | Forma cristalina de AZD9291 deuterado, procedimiento de preparación para la misma y uso de la misma |
| WO2019001425A1 (zh) * | 2017-06-27 | 2019-01-03 | 浙江同源康医药股份有限公司 | 一种氘代奥斯替尼衍生物及其应用 |
| TWI702205B (zh) * | 2017-10-06 | 2020-08-21 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 表皮生長因子受體抑制劑 |
| CN107954918B (zh) * | 2017-11-30 | 2022-01-25 | 郑州泰基鸿诺医药股份有限公司 | 一种n-氘代甲基吲哚类化合物的合成方法 |
| CN108047207A (zh) * | 2018-01-30 | 2018-05-18 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-2-氟代丙烯酰胺氘代物及应用 |
| CN110272420A (zh) * | 2018-03-16 | 2019-09-24 | 江苏正大丰海制药有限公司 | 氘代3-(4,5-取代氨基嘧啶)苯基化合物单甲磺酸盐晶型及其制备方法 |
| CN110950847B (zh) * | 2018-09-27 | 2022-11-01 | 浙江同源康医药股份有限公司 | 氘代azd9291化合物的新晶型及其用途 |
| CN110003183A (zh) * | 2019-04-09 | 2019-07-12 | 河南真实生物科技有限公司 | 2-（2，4，5-取代苯氨基）嘧啶衍生物及其晶形b |
| CN111909135A (zh) * | 2020-08-15 | 2020-11-10 | 天津大学 | 一种azd9291氘代物甲磺酸盐新盐型及其制备方法 |
| WO2022146201A1 (en) * | 2020-12-30 | 2022-07-07 | Joint Stock Company "Biocad" | Epidermal growth factor receptor inhibitors |
| CN113387935B (zh) * | 2021-07-23 | 2022-06-10 | 苏州雅深智慧科技有限公司 | 抑制三突变表皮生长因子受体酪氨酸激酶的化合物及用途 |
| CN113582976B (zh) * | 2021-08-24 | 2023-03-17 | 郑州大学 | 氘代2-取代苯胺-4-吲哚基嘧啶类衍生物及其制备方法和应用 |
| WO2025092926A1 (zh) * | 2023-10-31 | 2025-05-08 | 浙江同源康医药股份有限公司 | 一种嘧啶类衍生物的药物组合物 |
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| KR20110048571A (ko) * | 2008-09-03 | 2011-05-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제 |
| CN101676266B (zh) * | 2008-09-19 | 2011-10-26 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
| EP4119551A1 (en) * | 2011-07-27 | 2023-01-18 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds |
| CN104140418B (zh) * | 2014-08-15 | 2016-08-24 | 常州润诺生物科技有限公司 | 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途 |
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2014
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| JP2017523247A (ja) | 2017-08-17 |
| KR101937704B1 (ko) | 2019-01-14 |
| EP3181559B8 (en) | 2018-11-14 |
| WO2016023422A1 (zh) | 2016-02-18 |
| EP3181559A4 (en) | 2017-06-21 |
| CA2958095C (en) | 2023-09-26 |
| JP6418622B2 (ja) | 2018-11-07 |
| AU2015303641B2 (en) | 2018-04-12 |
| KR20170036107A (ko) | 2017-03-31 |
| CN104140418A (zh) | 2014-11-12 |
| US10414756B2 (en) | 2019-09-17 |
| EP3181559B1 (en) | 2018-10-03 |
| US20180016258A1 (en) | 2018-01-18 |
| CA2958095A1 (en) | 2016-02-18 |
| AU2015303641A1 (en) | 2017-03-23 |
| EP3181559A1 (en) | 2017-06-21 |
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Denomination of invention: Double layer cyclic 4-belts filtered well Effective date of registration: 20171108 Granted publication date: 20160824 Pledgee: TETRANOV PHARMACY STOCK INC. Pledgor: CHANGZHOU RUNNUO BIOLOGICAL TECHNOLOGY CO., LTD. Registration number: 2017990001040 |
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Effective date of registration: 20180105 Address after: 313100 Zhejiang Huzhou city Changxin Economic Development Zone Mingzhu road 1278 Changxin World Trade Building A 14 floor 1403-2 room Patentee after: Zhejiang homologous health medicine Limited by Share Ltd Address before: 213100 Jiangsu city of Changzhou province Hehai West New District No. 106 Co-patentee before: Guangzhou Boji Medical Biotechnology Co.,Ltd. Patentee before: CHANGZHOU RUNNUO BIOLOGICAL TECHNOLOGY CO., LTD. |