CN104119438A - 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 - Google Patents
延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 Download PDFInfo
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| CN111057152A (zh) * | 2019-12-11 | 2020-04-24 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
Families Citing this family (46)
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| CN105440123B (zh) | 2011-02-10 | 2020-10-09 | 罗切格利卡特公司 | 突变体白介素-2多肽 |
| MX342810B (es) | 2011-03-03 | 2016-10-13 | Apexigen Inc | Anticuerpos del receptor anti-interleucina-6 (anti-il-6) y sus metodos de uso. |
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| CA2850194C (en) | 2011-09-30 | 2023-03-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting elimination of antigens |
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| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20220136441A (ko) | 2012-02-24 | 2022-10-07 | 추가이 세이야쿠 가부시키가이샤 | ＦｃγＲＩＩＢ를 매개로 항원의 소실을 촉진하는 항원 결합 분자 |
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| AU2013334740A1 (en) * | 2012-10-25 | 2015-04-02 | Medimmune, Llc | Stable, low viscosity antibody formulation |
| US10772940B1 (en) * | 2012-12-11 | 2020-09-15 | University Of Kentucky Research Foundation | Cocaine hydrolase-FC fusion proteins for cocaine and methods for utilizing the same |
| JP6461808B2 (ja) * | 2012-12-17 | 2019-01-30 | ラボラトワール フランセ ドゥ フラクションマン エ デ バイオテクノロジーズＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ Ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ Ｅｔ Ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | 炎症および細菌感染症処置におけるモノクローナル抗体の使用 |
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| KR102101987B1 (ko) * | 2013-10-31 | 2020-04-20 | 리제너론 파마슈티칼스 인코포레이티드 | 중화 항체를 검출하기 위한 경합 리간드 결합 분석 |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| MY185114A (en) | 2014-11-07 | 2021-04-30 | Sesen Bio Inc | Improved il-6 antibodies |
| US20170029499A1 (en) | 2015-07-31 | 2017-02-02 | Astrazeneca Pharmaceuticals Lp | Methods for treating hepcidin-mediated disorders |
| CN108718522A (zh) * | 2016-02-23 | 2018-10-30 | 赛森生物股份有限公司 | Il-6拮抗剂制剂及其用途 |
| JP2019519470A (ja) * | 2016-04-07 | 2019-07-11 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ−６受容体へのｉｌ−６の結合を遮断する薬剤を用いたうつ病の治療 |
| EP3511340B1 (en) | 2016-08-10 | 2024-10-02 | Ajou University Industry-Academic Cooperation Foundation | Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same |
| JP7630906B2 (ja) * | 2017-02-01 | 2025-02-18 | イェール・ユニヴァーシティー | 利尿薬耐性の治療 |
| MA51584A (fr) * | 2018-01-05 | 2020-11-11 | Corvidia Therapeutics Inc | Méthodes de traitement d'une inflammation médiée par il-6 sans immunosuppression |
| WO2020023644A2 (en) | 2018-07-24 | 2020-01-30 | Medimmune, Llc | Antibody directed against s. aureus clumping factor a (clfa) |
| AU2019359207A1 (en) | 2018-10-09 | 2021-05-20 | Humabs Biomed Sa | Antibodies directed against Staphylococcus aureus leukotoxins |
| CN113164602A (zh) | 2018-10-09 | 2021-07-23 | 免疫医疗有限责任公司 | 抗金黄色葡萄球菌抗体的组合 |
| WO2020185986A1 (en) | 2019-03-13 | 2020-09-17 | Medimmune, Llc | Decreasing staphylococcus aureus infections in colonized patients |
| EP4591885A3 (en) | 2019-05-01 | 2025-11-19 | Novo Nordisk A/S | Anti-il-6 antibody formulation |
| CA3163270A1 (fr) * | 2019-12-31 | 2021-07-08 | Rene Azoulai | Composition pharmaceutique pour la prevention ou le traitement des douleurs post-operatoires |
| WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
| ES2973425T3 (es) | 2020-03-26 | 2024-06-20 | Univ Vanderbilt | Anticuerpos monoclonales humanos dirigidos contra el coronavirus 2 del síndrome respiratorio agudo grave (sars-cov-2) |
| JP2023528235A (ja) | 2020-05-17 | 2023-07-04 | アストラゼネカ・ユーケイ・リミテッド | ＳＡＲＳ－ＣｏＶ－２抗体、並びにこれを選択及び使用する方法 |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| CN116234577A (zh) | 2020-08-10 | 2023-06-06 | 阿斯利康(英国)有限公司 | 用于治疗和预防covid-19的sars-cov-2抗体 |
| CN114681592A (zh) * | 2020-12-31 | 2022-07-01 | 天境生物科技(杭州)有限公司 | 包含可溶性gp130二聚体的制剂和使用方法 |
| TW202342095A (zh) | 2021-11-05 | 2023-11-01 | 英商阿斯特捷利康英國股份有限公司 | 用於治療和預防ｃｏｖｉｄ—１９之組成物 |
| TW202342510A (zh) | 2022-02-18 | 2023-11-01 | 英商Ｒｑ生物科技有限公司 | 抗體 |
| CR20240528A (es) | 2022-04-29 | 2025-04-04 | Astrazeneca Uk Ltd | Anticuerpos contra el sars-cov-2 y métodos para utilizarlos |
| KR20250071252A (ko) * | 2022-09-30 | 2025-05-21 | 소네트 바이오테라퓨틱스, 인크. | 저 투여량 il-6 제형 및 이의 사용 방법 |
| WO2025106418A1 (en) * | 2023-11-13 | 2025-05-22 | Seaport Therapeutics, Inc. | Lipid prodrugs of allopregnanolone and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2299241T3 (es) * | 1998-03-17 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6. |
| US7658921B2 (en) * | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| ES2649037T3 (es) * | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
| CN100374457C (zh) * | 2001-11-14 | 2008-03-12 | 森托科尔公司 | 抗il-6抗体、组合物、方法和用途 |
| DE60305919T2 (de) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
| HRP20050934B1 (hr) * | 2003-04-04 | 2014-09-26 | Genentech, Inc. | Formulacije s visokom koncentracijom antitijela i proteina |
| JP2008518936A (ja) * | 2004-10-29 | 2008-06-05 | メディミューン，インコーポレーテッド | Ｒｓｖ感染症および関連状態を予防および治療する方法 |
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| ES2523666T3 (es) * | 2005-05-31 | 2014-11-28 | Board Of Regents, The University Of Texas System | Anticuerpos IgG1 con la parte Fc mutada para el aumento de unión al receptor FcRn y usos de los mismos |
| EP1899477A4 (en) * | 2005-07-01 | 2010-01-20 | Medimmune Inc | INTEGRATED APPROACH FOR GENERATING MULTIDOMAIN PROTEIN THERAPEUTIC APPLICATIONS |
| WO2007092772A2 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Inc. | Protein formulations |
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| TW200837080A (en) * | 2007-01-09 | 2008-09-16 | Wyeth Corp | Anti-IL-13 antibody formulations and uses thereof |
| EP2703011A3 (en) * | 2007-05-07 | 2014-03-26 | MedImmune, LLC | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| TWI617576B (zh) * | 2007-05-21 | 2018-03-11 | 艾爾德生物控股有限責任公司 | 介白素-６（ｉｌ-６）的抗體及其等之用途 |
| CA2692165A1 (en) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| US20110008329A1 (en) * | 2007-06-26 | 2011-01-13 | Medlmmune, Llc | Methods of Treating RSV Infections And Related Conditions |
| WO2010088444A1 (en) * | 2009-01-29 | 2010-08-05 | Medimmune, Llc | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111057152A (zh) * | 2019-12-11 | 2020-04-24 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
| CN111057152B (zh) * | 2019-12-11 | 2022-03-11 | 中国人民解放军第四军医大学 | 一种抗人IL-6Ra单克隆抗体及其应用 |
Also Published As
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| MX2011007832A (es) | 2011-10-06 |
| RU2011135422A (ru) | 2013-03-10 |
| CN102387814A (zh) | 2012-03-21 |
| EP2391384A1 (en) | 2011-12-07 |
| RU2650594C1 (ru) | 2018-04-17 |
| HK1201847A1 (en) | 2015-09-11 |
| WO2010088444A1 (en) | 2010-08-05 |
| BRPI1007005A2 (pt) | 2016-03-22 |
| ZA201207249B (en) | 2013-08-28 |
| US20140302058A1 (en) | 2014-10-09 |
| SG172354A1 (en) | 2011-07-28 |
| EP2391384A4 (en) | 2012-12-26 |
| ZA201104796B (en) | 2018-11-28 |
| MX337590B (es) | 2016-03-11 |
| AU2010208125B2 (en) | 2015-02-12 |
| JP2017206519A (ja) | 2017-11-24 |
| AU2010208125A1 (en) | 2011-07-21 |
| KR20110108398A (ko) | 2011-10-05 |
| CA2749200A1 (en) | 2010-08-05 |
| JP2012516158A (ja) | 2012-07-19 |
| SG2014007637A (en) | 2014-03-28 |
| SG10201704214VA (en) | 2017-06-29 |
| JP2016019517A (ja) | 2016-02-04 |
| US20120034212A1 (en) | 2012-02-09 |
| US20170101468A1 (en) | 2017-04-13 |
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