CN104093848A - 碳青霉烯(carbapenem)的无细胞制备 - Google Patents

碳青霉烯(carbapenem)的无细胞制备 Download PDF

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Publication number
CN104093848A
CN104093848A CN201280054408.6A CN201280054408A CN104093848A CN 104093848 A CN104093848 A CN 104093848A CN 201280054408 A CN201280054408 A CN 201280054408A CN 104093848 A CN104093848 A CN 104093848A
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substituted
optionally
salt
formula
group
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Chinese (zh)
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威廉·杰瑞米·布雷克
丹尼尔·克莱恩-马库斯查梅尔
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Greenlight Biosciences Inc
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Greenlight Biosciences Inc
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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    • C12N9/93—Ligases (6)
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01041—Glutamate-5-semialdehyde dehydrogenase (1.2.1.41)
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    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/99—Oxidoreductases acting on the CH-NH group of donors (1.5) with other acceptors (1.5.99)
    • C12Y105/99008—Proline dehydrogenase (1.5.99.8)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02011—Glutamate 5-kinase (2.7.2.11)
    • C—CHEMISTRY; METALLURGY
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    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/03—Cyclo-ligases (6.3.3)
    • C12Y603/03004—(Carboxyethyl)arginine beta-lactam-synthase (6.3.3.4)
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    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04016—Carbamoyl-phosphate synthase (ammonia) (6.3.4.16)
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    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
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  • Public Health (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201280054408.6A 2011-09-09 2012-09-07 碳青霉烯(carbapenem)的无细胞制备 Pending CN104093848A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161533039P 2011-09-09 2011-09-09
US61/533,039 2011-09-09
PCT/US2012/054195 WO2013036787A2 (en) 2011-09-09 2012-09-07 Cell-free preparation of carbapenems

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Publication Number Publication Date
CN104093848A true CN104093848A (zh) 2014-10-08

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CN201280054408.6A Pending CN104093848A (zh) 2011-09-09 2012-09-07 碳青霉烯(carbapenem)的无细胞制备

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US (2) US9469861B2 (enExample)
EP (1) EP2753702B1 (enExample)
JP (1) JP2014526250A (enExample)
KR (1) KR20150010932A (enExample)
CN (1) CN104093848A (enExample)
CA (1) CA2846893A1 (enExample)
IL (1) IL231010A0 (enExample)
SG (1) SG2014014377A (enExample)
WO (1) WO2013036787A2 (enExample)

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