CN104093702A - 用于制备药物试剂的方法和中间体 - Google Patents
用于制备药物试剂的方法和中间体 Download PDFInfo
- Publication number
- CN104093702A CN104093702A CN201380007712.XA CN201380007712A CN104093702A CN 104093702 A CN104093702 A CN 104093702A CN 201380007712 A CN201380007712 A CN 201380007712A CN 104093702 A CN104093702 A CN 104093702A
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- 0 C*[C@](CC([C@@](*)Cc1ccccc1)OC(*)=S)Cc1ccccc1 Chemical compound C*[C@](CC([C@@](*)Cc1ccccc1)OC(*)=S)Cc1ccccc1 0.000 description 15
- QIPMIORXMFOSED-GJWBHKRUSA-N CC(C)/C(/C)=N/C(/CN(C)C(N[C@@H](CCN1CCOCC1)C(N[C@H](CC[C@H](Cc1ccccc1)NC(OCc1cnc[s]1)=O)Cc1ccccc1)=O)=O)=C\S Chemical compound CC(C)/C(/C)=N/C(/CN(C)C(N[C@@H](CCN1CCOCC1)C(N[C@H](CC[C@H](Cc1ccccc1)NC(OCc1cnc[s]1)=O)Cc1ccccc1)=O)=O)=C\S QIPMIORXMFOSED-GJWBHKRUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/12—Dithiocarbonic acids; Derivatives thereof
- C07C329/14—Esters of dithiocarbonic acids
- C07C329/16—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594686P | 2012-02-03 | 2012-02-03 | |
| US61/594,686 | 2012-02-03 | ||
| PCT/US2013/024431 WO2013116715A1 (en) | 2012-02-03 | 2013-02-01 | Methods and intermediates for preparing pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104093702A true CN104093702A (zh) | 2014-10-08 |
Family
ID=47754962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380007712.XA Pending CN104093702A (zh) | 2012-02-03 | 2013-02-01 | 用于制备药物试剂的方法和中间体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9346796B2 (enExample) |
| EP (1) | EP2809646A1 (enExample) |
| JP (1) | JP2015510509A (enExample) |
| KR (1) | KR20140128392A (enExample) |
| CN (1) | CN104093702A (enExample) |
| AU (1) | AU2013214879A1 (enExample) |
| BR (1) | BR112014018738A8 (enExample) |
| CA (1) | CA2862344A1 (enExample) |
| HK (1) | HK1205095A1 (enExample) |
| IL (1) | IL233654A0 (enExample) |
| IN (1) | IN2014DN06192A (enExample) |
| MX (1) | MX2014009344A (enExample) |
| RU (1) | RU2014129937A (enExample) |
| SG (2) | SG11201404527QA (enExample) |
| WO (1) | WO2013116715A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104557565A (zh) * | 2015-01-08 | 2015-04-29 | 浙江工业大学 | 抗艾滋病药物增强剂Cobicistat关键中间体盐酸盐的制备方法 |
| CN107513046A (zh) * | 2016-06-15 | 2017-12-26 | 江苏福瑞生物医药有限公司 | 一种可比司他的合成方法 |
| CN112500367A (zh) * | 2020-12-16 | 2021-03-16 | 盐城迪赛诺制药有限公司 | 一种利托那韦中间体的精制方法 |
| CN112592324A (zh) * | 2020-12-16 | 2021-04-02 | 盐城迪赛诺制药有限公司 | 一种纯化利托那韦中间体原料的方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104370777A (zh) * | 2013-08-13 | 2015-02-25 | 上海迪赛诺化学制药有限公司 | 合成(2r,5r)-1,6-二苯基己烷-2,5-二胺及其盐的中间体及所述中间体的制备方法和应用 |
| US9975864B2 (en) | 2013-12-03 | 2018-05-22 | Mylan Laboratories Limited | Preparation of cobicistat intermediates |
| CN104193643B (zh) * | 2014-09-12 | 2016-02-10 | 宁波九胜创新医药科技有限公司 | 用于合成抗艾滋病药物增强剂cobicistat的中间体 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994014436A1 (en) * | 1992-12-29 | 1994-07-07 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO2008010921A2 (en) * | 2006-07-07 | 2008-01-24 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| WO2010115000A2 (en) * | 2009-04-03 | 2010-10-07 | Gilead Sciences, Inc. | Methods and intermediates for preparing pharmaceutical agents |
| CN101967130A (zh) * | 2010-07-02 | 2011-02-09 | 厦门市亨瑞生化有限公司 | 利托那韦中间体的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IE913840A1 (en) | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
| US5763464A (en) * | 1995-11-22 | 1998-06-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Retroviral agents containing anthranilamide, substituted benzamide and other subunits, and methods of using same |
| US20030153771A1 (en) | 2001-09-27 | 2003-08-14 | Kolb Hartmuth C. | Large scale synthesis of optically pure aziridines |
| AU2003232173A1 (en) | 2002-06-12 | 2003-12-31 | Qsi Pharma A/S | Compounds and methods for controlling bacterial virulence |
| WO2008027932A2 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Cytochrome p450 oxidase inhibitors and uses thereof |
| ES2779826T3 (es) | 2007-02-23 | 2020-08-20 | Gilead Sciences Inc | Moduladores de propiedades farmacocinéticas de agentes terapéuticos |
| MX342377B (es) | 2008-05-02 | 2016-09-27 | Gilead Sciences Inc | Uso de particulas trasportadoras solidas para mejorar la capacidad de procesamiento de un agente farmaceutico. |
| WO2012088153A1 (en) | 2010-12-21 | 2012-06-28 | Gilead Sciences, Inc. | Inhibitors of cytochrome p450 |
-
2013
- 2013-02-01 HK HK15105030.4A patent/HK1205095A1/xx unknown
- 2013-02-01 US US14/372,995 patent/US9346796B2/en active Active
- 2013-02-01 WO PCT/US2013/024431 patent/WO2013116715A1/en not_active Ceased
- 2013-02-01 IN IN6192DEN2014 patent/IN2014DN06192A/en unknown
- 2013-02-01 SG SG11201404527QA patent/SG11201404527QA/en unknown
- 2013-02-01 KR KR20147024292A patent/KR20140128392A/ko not_active Withdrawn
- 2013-02-01 CN CN201380007712.XA patent/CN104093702A/zh active Pending
- 2013-02-01 MX MX2014009344A patent/MX2014009344A/es unknown
- 2013-02-01 BR BR112014018738A patent/BR112014018738A8/pt not_active IP Right Cessation
- 2013-02-01 AU AU2013214879A patent/AU2013214879A1/en not_active Abandoned
- 2013-02-01 SG SG10201509336RA patent/SG10201509336RA/en unknown
- 2013-02-01 RU RU2014129937A patent/RU2014129937A/ru not_active Application Discontinuation
- 2013-02-01 JP JP2014555782A patent/JP2015510509A/ja not_active Withdrawn
- 2013-02-01 EP EP13706786.4A patent/EP2809646A1/en not_active Withdrawn
- 2013-02-01 CA CA2862344A patent/CA2862344A1/en not_active Abandoned
-
2014
- 2014-07-15 IL IL233654A patent/IL233654A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994014436A1 (en) * | 1992-12-29 | 1994-07-07 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO2008010921A2 (en) * | 2006-07-07 | 2008-01-24 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| CN101490023A (zh) * | 2006-07-07 | 2009-07-22 | 吉里德科学公司 | 治疗剂的药代动力学特性调节剂 |
| WO2010115000A2 (en) * | 2009-04-03 | 2010-10-07 | Gilead Sciences, Inc. | Methods and intermediates for preparing pharmaceutical agents |
| CN101967130A (zh) * | 2010-07-02 | 2011-02-09 | 厦门市亨瑞生化有限公司 | 利托那韦中间体的合成方法 |
Non-Patent Citations (3)
| Title |
|---|
| ARUN K. GHOSH等: ""Potent HIV-1Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic"", 《J. ORG. CHEM.》 * |
| ERRABELLI RAMU等: ""A short approach to the synthesis of the ritonavir and lopinavir core and its C-3 epimer via cross metathesis"", 《TETRAHEDRON: ASYMMETRY》 * |
| MUKUND K. GURJAR等: ""Synthesis of Novel C2-symmetric and Pseudo C2-symmetric Based Diols, Epoxides and Dideoxy Derivatives of HIV Protease Inhibitors"", 《TETRAHEDRON》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104557565A (zh) * | 2015-01-08 | 2015-04-29 | 浙江工业大学 | 抗艾滋病药物增强剂Cobicistat关键中间体盐酸盐的制备方法 |
| CN107513046A (zh) * | 2016-06-15 | 2017-12-26 | 江苏福瑞生物医药有限公司 | 一种可比司他的合成方法 |
| CN107513046B (zh) * | 2016-06-15 | 2019-12-13 | 江苏欧信制药有限公司 | 一种可比司他的合成方法 |
| CN112500367A (zh) * | 2020-12-16 | 2021-03-16 | 盐城迪赛诺制药有限公司 | 一种利托那韦中间体的精制方法 |
| CN112592324A (zh) * | 2020-12-16 | 2021-04-02 | 盐城迪赛诺制药有限公司 | 一种纯化利托那韦中间体原料的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014018738A2 (enExample) | 2017-06-20 |
| KR20140128392A (ko) | 2014-11-05 |
| CA2862344A1 (en) | 2013-08-08 |
| AU2013214879A1 (en) | 2014-08-07 |
| MX2014009344A (es) | 2015-05-11 |
| US20140364602A1 (en) | 2014-12-11 |
| JP2015510509A (ja) | 2015-04-09 |
| US9346796B2 (en) | 2016-05-24 |
| SG10201509336RA (en) | 2015-12-30 |
| WO2013116715A1 (en) | 2013-08-08 |
| HK1205095A1 (en) | 2015-12-11 |
| BR112014018738A8 (pt) | 2017-07-11 |
| IN2014DN06192A (enExample) | 2015-10-23 |
| RU2014129937A (ru) | 2016-03-27 |
| EP2809646A1 (en) | 2014-12-10 |
| IL233654A0 (en) | 2014-08-31 |
| SG11201404527QA (en) | 2014-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: American California Applicant after: Gilead Sciences Inc. Address before: American California Applicant before: Gilead Sciences Inc. |
|
| COR | Change of bibliographic data | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141008 |