CN1040876C - 红霉素的新衍生物和它们的制备方法及其作为药物的应用 - Google Patents
红霉素的新衍生物和它们的制备方法及其作为药物的应用 Download PDFInfo
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- CN1040876C CN1040876C CN93114229A CN93114229A CN1040876C CN 1040876 C CN1040876 C CN 1040876C CN 93114229 A CN93114229 A CN 93114229A CN 93114229 A CN93114229 A CN 93114229A CN 1040876 C CN1040876 C CN 1040876C
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 230000000505 pernicious effect Effects 0.000 description 1
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- 125000003367 polycyclic group Chemical group 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
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- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
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- 125000000335 thiazolyl group Chemical group 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9213320A FR2697523B1 (fr) | 1992-11-05 | 1992-11-05 | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR9213320 | 1992-11-05 | ||
| FR9308109 | 1993-07-02 | ||
| FR9308109A FR2707088B1 (fr) | 1993-07-02 | 1993-07-02 | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1090581A CN1090581A (zh) | 1994-08-10 |
| CN1040876C true CN1040876C (zh) | 1998-11-25 |
Family
ID=26229842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93114229A Expired - Lifetime CN1040876C (zh) | 1992-11-05 | 1993-11-05 | 红霉素的新衍生物和它们的制备方法及其作为药物的应用 |
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|---|---|
| US (2) | US5527780A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0596802B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP3000022B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100317149B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1040876C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE135706T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU670329B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9304481A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2102457C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69301897T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0596802T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2085130T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3019385T3 (cg-RX-API-DMAC7.html) |
| HU (3) | HU220048B (cg-RX-API-DMAC7.html) |
| MA (1) | MA23018A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2126416C1 (cg-RX-API-DMAC7.html) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2732023B1 (fr) * | 1995-03-22 | 1997-04-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2732684B1 (fr) * | 1995-04-06 | 1997-04-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5747466A (en) * | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| IL128681A0 (en) * | 1996-09-04 | 2000-01-31 | Abbott Lab | 6-O substituted ketolides having antibacterial activity |
| FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2760017B1 (fr) * | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
| US5922683A (en) * | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
| EP0988308A1 (en) * | 1997-06-11 | 2000-03-29 | Pfizer Products Inc. | 9-oxime erythromycin derivatives |
| US5780604A (en) * | 1997-09-26 | 1998-07-14 | Abbott Laboratories | 11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides |
| US6034069A (en) * | 1997-09-30 | 2000-03-07 | Abbott Laboratories | 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity |
| US6124269A (en) * | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| AU9649698A (en) * | 1997-10-29 | 1999-05-17 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a 11, 12-carbamate derivatives |
| ZA989835B (en) * | 1997-10-29 | 1999-05-05 | Taisho Pharmaceutical Co Ltd | Erythromycin a derivatives |
| US6046171A (en) * | 1997-10-29 | 2000-04-04 | Abbott Laboratories | 6,11-bridged erythromycin derivatives |
| HRP980189B1 (en) * | 1998-04-06 | 2004-04-30 | Pliva Pharm & Chem Works | Novel 15-membered lactams ketolides |
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| JP4573925B2 (ja) * | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
| FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
| EP1115732B1 (en) | 1998-09-22 | 2005-06-29 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
| FR2785612A1 (fr) * | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| BR9914998A (pt) * | 1998-11-03 | 2001-07-10 | Pfizer Prod Inc | Antibióticos macrólidos |
| FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| ATE344269T1 (de) | 1998-12-10 | 2006-11-15 | Pfizer Prod Inc | Carbamat und carbazat ketolid antibiotika |
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| FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US6054435A (en) * | 1999-03-19 | 2000-04-25 | Abbott Laboratories | 6-O-substituted macrolides having antibacterial activity |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) * | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| AU773678B2 (en) | 1999-04-16 | 2004-06-03 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| HRP990116B1 (en) * | 1999-04-20 | 2007-10-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | NOVEL 8a AND 9a- 15-MEMBERED LACTAMES |
| OA11945A (en) * | 1999-05-24 | 2006-04-13 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
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| EP0487411A1 (fr) * | 1990-11-21 | 1992-05-27 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation, les nouveaux intermédiaires obtenus et leur application comme médicaments |
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| GR77556B (cg-RX-API-DMAC7.html) * | 1982-11-15 | 1984-09-24 | Pfizer | |
| JPS6229595A (ja) * | 1985-07-31 | 1987-02-07 | Toyo Jozo Co Ltd | ５−ｏ−マイカミノシル−ナルボノライド誘導体およびその製法 |
| US4742049A (en) * | 1986-06-04 | 1988-05-03 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
| US5075289A (en) * | 1988-06-07 | 1991-12-24 | Abbott Laboratories | 9-r-azacyclic erythromycin antibiotics |
| FR2692579B1 (fr) * | 1992-06-19 | 1995-06-02 | Roussel Uclaf | Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2702480B1 (fr) * | 1993-03-09 | 1995-04-28 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
-
1993
- 1993-11-01 US US08/146,697 patent/US5527780A/en not_active Expired - Lifetime
- 1993-11-02 MA MA23324A patent/MA23018A1/fr unknown
- 1993-11-04 ES ES93402704T patent/ES2085130T3/es not_active Expired - Lifetime
- 1993-11-04 CA CA002102457A patent/CA2102457C/fr not_active Expired - Lifetime
- 1993-11-04 EP EP93402704A patent/EP0596802B1/fr not_active Expired - Lifetime
- 1993-11-04 DE DE69301897T patent/DE69301897T2/de not_active Expired - Lifetime
- 1993-11-04 BR BR9304481A patent/BR9304481A/pt not_active Application Discontinuation
- 1993-11-04 RU RU93050129A patent/RU2126416C1/ru active
- 1993-11-04 AT AT93402704T patent/ATE135706T1/de active
- 1993-11-04 DK DK93402704.6T patent/DK0596802T3/da active
- 1993-11-04 JP JP5297603A patent/JP3000022B2/ja not_active Expired - Lifetime
- 1993-11-05 HU HU9303148A patent/HU220048B/hu unknown
- 1993-11-05 HU HU0003975A patent/HU221978B1/hu active IP Right Grant
- 1993-11-05 CN CN93114229A patent/CN1040876C/zh not_active Expired - Lifetime
- 1993-11-05 AU AU50477/93A patent/AU670329B2/en not_active Expired
- 1993-11-05 HU HU0200629D patent/HU222113B1/hu active IP Right Grant
- 1993-11-05 KR KR1019930023371A patent/KR100317149B1/ko not_active Expired - Lifetime
-
1995
- 1995-02-21 US US08/391,959 patent/US5614614A/en not_active Expired - Lifetime
-
1996
- 1996-03-21 GR GR950403179T patent/GR3019385T3/el unknown
-
1998
- 1998-09-03 JP JP26389698A patent/JP3151188B2/ja not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0487411A1 (fr) * | 1990-11-21 | 1992-05-27 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation, les nouveaux intermédiaires obtenus et leur application comme médicaments |
| WO1992009614A1 (en) * | 1990-11-28 | 1992-06-11 | Taisho Pharmaceutical Co., Ltd. | 6-o-methylerythromycin a derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| HU221978B1 (hu) | 2003-03-28 |
| HU222113B1 (hu) | 2003-04-28 |
| AU670329B2 (en) | 1996-07-11 |
| JPH11180994A (ja) | 1999-07-06 |
| JP3151188B2 (ja) | 2001-04-03 |
| MA23018A1 (fr) | 1994-07-01 |
| US5614614A (en) | 1997-03-25 |
| AU5047793A (en) | 1994-05-19 |
| EP0596802B1 (fr) | 1996-03-20 |
| CA2102457A1 (fr) | 1994-05-06 |
| CN1090581A (zh) | 1994-08-10 |
| DK0596802T3 (da) | 1996-06-03 |
| KR100317149B1 (ko) | 2002-06-20 |
| DE69301897D1 (de) | 1996-04-25 |
| HU220048B (hu) | 2001-10-28 |
| JP3000022B2 (ja) | 2000-01-17 |
| KR940011474A (ko) | 1994-06-21 |
| HUT66446A (en) | 1994-11-28 |
| HU0003975D0 (cg-RX-API-DMAC7.html) | 2000-12-28 |
| ATE135706T1 (de) | 1996-04-15 |
| ES2085130T3 (es) | 1996-05-16 |
| JPH06220082A (ja) | 1994-08-09 |
| DE69301897T2 (de) | 1996-11-07 |
| CA2102457C (fr) | 2002-01-22 |
| GR3019385T3 (en) | 1996-06-30 |
| US5527780A (en) | 1996-06-18 |
| BR9304481A (pt) | 1994-06-21 |
| RU2126416C1 (ru) | 1999-02-20 |
| EP0596802A1 (fr) | 1994-05-11 |
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Owner name: LUSUO ROUSSEL UCLAF CO., LTD. Free format text: FORMER NAME OR ADDRESS: ROUSSEL-UCLAF Owner name: HOECHST MARION ROUSSEL INC. Free format text: FORMER NAME OR ADDRESS: LUSUO ROUSSEL UCLAF CO., LTD. Owner name: VENTIS PHARMA S.A. Free format text: FORMER NAME OR ADDRESS: HOECHST MARION ROUSSEL INC. |
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Address after: French Anthony Patentee after: AVENTIS PHARMA S.A. Address before: French AUX Patentee before: Hoechst Marion Roussel Address after: French Roman Patentee after: Roussel-Uclaf Address before: Paris France Patentee before: ROUSSEL UCLAF Address after: French AUX Patentee after: Hoechst Marion Roussel Address before: French Roman Patentee before: Roussel-Uclaf |
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Expiration termination date: 20131105 Granted publication date: 19981125 |