CN1040326C - 咪唑并吡啶paf/h1拮抗剂的制备方法 - Google Patents

咪唑并吡啶paf/h1拮抗剂的制备方法 Download PDF

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Publication number
CN1040326C
CN1040326C CN92100974A CN92100974A CN1040326C CN 1040326 C CN1040326 C CN 1040326C CN 92100974 A CN92100974 A CN 92100974A CN 92100974 A CN92100974 A CN 92100974A CN 1040326 C CN1040326 C CN 1040326C
Authority
CN
China
Prior art keywords
pyridin
formula
dihydro
benzo
methylimidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92100974A
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English (en)
Chinese (zh)
Other versions
CN1064275A (zh
Inventor
D·阿尔克
R·J·巴斯
K·库珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
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Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN1064275A publication Critical patent/CN1064275A/zh
Application granted granted Critical
Publication of CN1040326C publication Critical patent/CN1040326C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Prostheses (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
CN92100974A 1991-02-13 1992-02-13 咪唑并吡啶paf/h1拮抗剂的制备方法 Expired - Fee Related CN1040326C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919102997A GB9102997D0 (en) 1991-02-13 1991-02-13 Therapeutic agents
GB9102997.5 1991-02-13

Publications (2)

Publication Number Publication Date
CN1064275A CN1064275A (zh) 1992-09-09
CN1040326C true CN1040326C (zh) 1998-10-21

Family

ID=10689943

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92100974A Expired - Fee Related CN1040326C (zh) 1991-02-13 1992-02-13 咪唑并吡啶paf/h1拮抗剂的制备方法

Country Status (29)

Country Link
US (1) US5358953A (OSRAM)
EP (1) EP0572425B1 (OSRAM)
JP (1) JP2506541B2 (OSRAM)
KR (1) KR970005302B1 (OSRAM)
CN (1) CN1040326C (OSRAM)
AT (1) ATE109482T1 (OSRAM)
AU (1) AU650322B2 (OSRAM)
BR (1) BR9205615A (OSRAM)
CA (1) CA2099381C (OSRAM)
CZ (1) CZ280504B6 (OSRAM)
DE (1) DE69200304T2 (OSRAM)
DK (1) DK0572425T3 (OSRAM)
EG (1) EG20085A (OSRAM)
ES (1) ES2059212T3 (OSRAM)
FI (1) FI933531A7 (OSRAM)
GB (1) GB9102997D0 (OSRAM)
HU (2) HUT65947A (OSRAM)
IE (1) IE65125B1 (OSRAM)
IL (1) IL100887A (OSRAM)
MX (1) MX9200589A (OSRAM)
MY (1) MY108437A (OSRAM)
NO (1) NO300592B1 (OSRAM)
NZ (1) NZ241597A (OSRAM)
PL (1) PL169304B1 (OSRAM)
RU (1) RU2114845C1 (OSRAM)
TW (1) TW227000B (OSRAM)
WO (1) WO1992014734A1 (OSRAM)
YU (1) YU48238B (OSRAM)
ZA (1) ZA921005B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5753671A (en) * 1994-08-10 1998-05-19 British Biotech Pharmaceuticals Limited Imidazopyridine derivatives as dual histamine (H1) and platelet activating factor (PAF) antagonists
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
MX9707187A (es) * 1995-08-05 1997-11-29 British Biotech Pharm Derivados de imidazopiridina.
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
ES2572454T3 (es) 2003-05-15 2016-05-31 Ampio Pharmaceuticals Inc Tratamiento de enfermedades mediadas por los linfocitos T
US7687515B2 (en) * 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
CA2713293A1 (en) 2008-01-30 2009-08-06 Nippon Zoki Pharmaceutical Co., Ltd. Piperidine derivative
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc THERAPEUTIC PROCESSES AND COMPOUNDS
CN103619839B (zh) * 2011-06-28 2016-06-01 福建省闽东力捷迅药业有限公司 抗-变态反应的苯并环庚并噻吩衍生物
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
AU2012323320B2 (en) 2011-10-10 2017-05-11 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2771007B1 (en) * 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN113880801A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
WO1989010363A1 (en) * 1988-04-28 1989-11-02 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture and their use as paf antagonists, antihistamines and/or antiinflammatory agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (OSRAM) * 1963-04-24
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5114919A (en) * 1990-02-26 1992-05-19 Merck & Co., Inc. Adjuncts in cancer chemotherapy
ATE112567T1 (de) * 1990-05-09 1994-10-15 Pfizer Imidazo(4,5-c>pyridine als paf antagonisten.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
WO1989010363A1 (en) * 1988-04-28 1989-11-02 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture and their use as paf antagonists, antihistamines and/or antiinflammatory agents

Also Published As

Publication number Publication date
PL169304B1 (pl) 1996-06-28
ATE109482T1 (de) 1994-08-15
JPH06504992A (ja) 1994-06-09
EG20085A (en) 1997-05-31
FI933531A0 (fi) 1993-08-10
MY108437A (en) 1996-09-30
GB9102997D0 (en) 1991-03-27
DE69200304D1 (de) 1994-09-08
AU650322B2 (en) 1994-06-16
IL100887A (en) 1996-01-19
KR970005302B1 (ko) 1997-04-15
YU48238B (sh) 1997-08-22
NO300592B1 (no) 1997-06-23
AU1168392A (en) 1992-09-15
WO1992014734A1 (en) 1992-09-03
NO932889D0 (no) 1993-08-13
FI933531L (fi) 1993-08-10
DE69200304T2 (de) 1994-12-08
IE920449A1 (en) 1992-08-12
NZ241597A (en) 1993-04-28
MX9200589A (es) 1992-10-01
HU9302327D0 (en) 1993-10-28
EP0572425B1 (en) 1994-08-03
US5358953A (en) 1994-10-25
HU211202A9 (en) 1995-11-28
FI933531A7 (fi) 1993-08-10
TW227000B (OSRAM) 1994-07-21
HUT65947A (en) 1994-08-29
YU14392A (sh) 1994-11-15
IL100887A0 (en) 1992-11-15
RU2114845C1 (ru) 1998-07-10
BR9205615A (pt) 1994-05-17
JP2506541B2 (ja) 1996-06-12
CA2099381A1 (en) 1992-08-14
CZ280504B6 (cs) 1996-02-14
EP0572425A1 (en) 1993-12-08
NO932889L (no) 1993-08-13
DK0572425T3 (da) 1994-09-12
CA2099381C (en) 1996-07-09
ZA921005B (en) 1993-08-12
CN1064275A (zh) 1992-09-09
CS42592A3 (en) 1992-09-16
IE65125B1 (en) 1995-10-04
ES2059212T3 (es) 1994-11-01

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