CN103816183A - 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 - Google Patents
间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 Download PDFInfo
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Abstract
Description
抗体 | 比例(%) | 抗体 | 比例(%) |
CD90 | 99.89 | Actin | ~0%阴性 |
CD29 | 99.96 | DR | ~0%阴性 |
CD73 | 99.98 | CD34 | ~0%阴性 |
CD49d | 99.91 | CD14 | ~0%阴性 |
CD45 | ~0%阴性 | ||
CD80 | 0.01 | ||
CD86 | 0.01 |
细胞因子(单位) | hADMPCs | SVF | 脐带干细胞 |
VEGF(pg/ml) | 16.80 | 23.73 | 18.14 |
TGF-β(pg/ml) | 401.00 | 173.19 | 413.70 |
GM-CSF(ng/ml) | 41.87 | 60.03 | 63.35 |
HGF(ng/ml) | 0.58 | 0.63 | 0.55 |
PDGF(ng/ml) | 0.01 | 0.01 | 0.02 |
IL-2(pg/ml) | 34.23 | 38.23 | 33.56 |
IL-10(pg/ml) | 44.15 | 41.46 | 40.38 |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201210466717.6A CN103816183A (zh) | 2012-11-16 | 2012-11-16 | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 |
PCT/CN2013/087284 WO2014075634A1 (zh) | 2012-11-16 | 2013-11-16 | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 |
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CN201210466717.6A CN103816183A (zh) | 2012-11-16 | 2012-11-16 | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 |
Publications (1)
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CN103816183A true CN103816183A (zh) | 2014-05-28 |
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CN201210466717.6A Pending CN103816183A (zh) | 2012-11-16 | 2012-11-16 | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 |
Country Status (2)
Country | Link |
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CN (1) | CN103816183A (zh) |
WO (1) | WO2014075634A1 (zh) |
Cited By (2)
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CN106031792A (zh) * | 2015-03-10 | 2016-10-19 | 西比曼生物科技(上海)有限公司 | 治疗关节软骨缺损的组合物 |
CN109355251A (zh) * | 2018-09-20 | 2019-02-19 | 瑞梦德医药科技(北京)有限公司 | 脂肪组织来源复合细胞群及其制备方法与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2645012T3 (es) * | 2004-09-24 | 2017-12-01 | Mesoblast, Inc. | Método para potenciar la proliferación y/o supervivencia de las células precursoras mesenquimales (MPC) |
JP5639058B2 (ja) * | 2008-09-03 | 2014-12-10 | メソブラスト,インコーポレーテッド | 造血前駆細胞の増殖 |
-
2012
- 2012-11-16 CN CN201210466717.6A patent/CN103816183A/zh active Pending
-
2013
- 2013-11-16 WO PCT/CN2013/087284 patent/WO2014075634A1/zh active Application Filing
Non-Patent Citations (8)
Title |
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DAVID D. FRISBIE ET AL.: "evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis", 《JOURNAL OF ORTHOPAEDIC RESEARCH DECEMBER》 * |
JORGE PAZ RODRIGUEZ ET AL.: "Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety", 《INTERNATIONAL ARCHIVES OF MEDICINE》 * |
余跃著: "《干细胞基础与临床》", 28 February 2008 * |
刘军等: "人原发性骨关节炎关节软骨间充质祖细胞生物学特性研究", 《中国博士学位论文全文数据库医药卫生科技辑》 * |
刘军等: "干细胞在骨性关节炎治疗中的理论与应用", 《中国组织工程研究与临床康复》 * |
刘毅主编: "《脂肪移植的基础与临床》", 31 May 2009 * |
李慧等: "脐带间充质干细胞对CIA大鼠炎症因子的干预", 《中国组织工程研究与临床康复》 * |
陈东旭等: "间充质干细胞治疗类风湿性关节炎的研究与应用", 《中国组织工程研究与临床康复》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106031792A (zh) * | 2015-03-10 | 2016-10-19 | 西比曼生物科技(上海)有限公司 | 治疗关节软骨缺损的组合物 |
CN107427558A (zh) * | 2015-03-10 | 2017-12-01 | 西比曼生物科技(上海)有限公司 | 治疗关节软骨缺损的组合物 |
CN109355251A (zh) * | 2018-09-20 | 2019-02-19 | 瑞梦德医药科技(北京)有限公司 | 脂肪组织来源复合细胞群及其制备方法与应用 |
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