CN107427558A - 治疗关节软骨缺损的组合物 - Google Patents

治疗关节软骨缺损的组合物 Download PDF

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Publication number
CN107427558A
CN107427558A CN201680014689.0A CN201680014689A CN107427558A CN 107427558 A CN107427558 A CN 107427558A CN 201680014689 A CN201680014689 A CN 201680014689A CN 107427558 A CN107427558 A CN 107427558A
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China
Prior art keywords
cell
composition
progenitor cells
surface antigen
cartilage
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CN201680014689.0A
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English (en)
Inventor
曹卫
汪文
李蒙
戴成祥
张丽
张露亿
王飞
李苏克
刘佳
蔡松柏
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Cellular Biomedicine Wuxi Co ltd
Cellular Biomedicine Group Shanghai Ltd
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Cellular Biomedicine Wuxi Co ltd
Cellular Biomedicine Group Shanghai Ltd
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Publication of CN107427558A publication Critical patent/CN107427558A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

一种治疗关节软骨缺损的组合物、制备方法、制剂和试剂盒，所述组合物包括：治疗有效量的脂肪间充质祖细胞、人血清白蛋白溶液和透明质酸钠。所述脂肪间充质祖细胞的95％以上具有表面抗原CD90、CD73、CD29和CD49d，还表达选自TGF‑β1、HGF和VEGF的细胞因子。所述组合物具有治疗关节软骨缺损效果。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201680014689.0A 2015-03-10 2016-03-10 治疗关节软骨缺损的组合物 Pending CN107427558A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015101048708 2015-03-10
CN201510104870.8A CN106031792A (zh) 2015-03-10 2015-03-10 治疗关节软骨缺损的组合物
PCT/CN2016/076082 WO2016141883A1 (zh) 2015-03-10 2016-03-10 治疗关节软骨缺损的组合物

Publications (1)

Publication Number Publication Date
CN107427558A true CN107427558A (zh) 2017-12-01

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CN201680014689.0A Pending CN107427558A (zh) 2015-03-10 2016-03-10 治疗关节软骨缺损的组合物

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Country Link
US (1) US20180117088A1 (zh)
CN (2) CN106031792A (zh)
WO (1) WO2016141883A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908178A (zh) * 2019-03-20 2019-06-21 江苏瑞思坦生物科技有限公司 脂肪血管基质组分在制备膝关节损伤治疗剂中的应用

Citations (7)

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CN101210232A (zh) * 2006-12-28 2008-07-02 天津昂赛细胞基因工程有限公司 一种间充质干细胞保存液及其用途
CN101385851A (zh) * 1999-02-01 2009-03-18 遗传研究所公司 用于关节软骨愈合和修复的方法和组合物
CN103550256A (zh) * 2013-10-21 2014-02-05 南京优而生物科技发展有限公司 自体脂肪间充质干细胞在制备治疗关节疾病药物的应用
CN103816183A (zh) * 2012-11-16 2014-05-28 臻景生物技术（上海）有限公司 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用
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WO2014143870A1 (en) * 2013-03-15 2014-09-18 Discgenics, Inc. Isolated discogenic cells, methods of using, and methods of preparing same from mammalian tissue
CN105106238A (zh) * 2015-08-10 2015-12-02 山东省药学科学院 一种用于治疗骨关节炎和软骨缺损的细胞治疗组合物

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AU2011213081A1 (en) * 2010-02-02 2012-08-23 University Of Rochester Methods of isolating and culturing mesenchymal stem cells

Patent Citations (8)

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CN101385851A (zh) * 1999-02-01 2009-03-18 遗传研究所公司 用于关节软骨愈合和修复的方法和组合物
CN101210232A (zh) * 2006-12-28 2008-07-02 天津昂赛细胞基因工程有限公司 一种间充质干细胞保存液及其用途
CN103816183A (zh) * 2012-11-16 2014-05-28 臻景生物技术（上海）有限公司 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用
CN103860593A (zh) * 2012-12-11 2014-06-18 臻景生物技术（上海）有限公司 间质血管层细胞和间充质祖细胞在预防或治疗类风湿性关节炎中的应用
WO2014143870A1 (en) * 2013-03-15 2014-09-18 Discgenics, Inc. Isolated discogenic cells, methods of using, and methods of preparing same from mammalian tissue
CN105308176A (zh) * 2013-03-15 2016-02-03 迪斯吉尼科斯有限公司 从哺乳动物组织分离的椎间盘细胞、使用方法及其制备方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908178A (zh) * 2019-03-20 2019-06-21 江苏瑞思坦生物科技有限公司 脂肪血管基质组分在制备膝关节损伤治疗剂中的应用

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CN106031792A (zh) 2016-10-19
WO2016141883A1 (zh) 2016-09-15
US20180117088A1 (en) 2018-05-03

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Application publication date: 20171201