CN108392624B - 活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 - Google Patents
活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 Download PDFInfo
- Publication number
- CN108392624B CN108392624B CN201810368844.XA CN201810368844A CN108392624B CN 108392624 B CN108392624 B CN 108392624B CN 201810368844 A CN201810368844 A CN 201810368844A CN 108392624 B CN108392624 B CN 108392624B
- Authority
- CN
- China
- Prior art keywords
- stem cells
- mesenchymal stem
- umbilical cord
- rheumatoid arthritis
- activity promoting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Description
组别 | 白蛋白(g/L) | 球蛋白(g/L) | A/G |
对照组0 | 37.2±1.03 | 35.1±1.02 | 0.99±0.06 |
适量组5 | 37.2±0.89 | 35.0±1.23 | 1.02±0.03 |
高剂量组100 | 36.8±0.73 | 34.4±1.29 | 1.03±0.05 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810368844.XA CN108392624B (zh) | 2018-04-23 | 2018-04-23 | 活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810368844.XA CN108392624B (zh) | 2018-04-23 | 2018-04-23 | 活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108392624A CN108392624A (zh) | 2018-08-14 |
CN108392624B true CN108392624B (zh) | 2020-08-25 |
Family
ID=63100388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810368844.XA Active CN108392624B (zh) | 2018-04-23 | 2018-04-23 | 活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108392624B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111202751A (zh) * | 2018-11-21 | 2020-05-29 | 清华大学 | 间充质干细胞在制备治疗类风湿性关节炎的产品中的应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101643719A (zh) * | 2009-07-27 | 2010-02-10 | 北京大学人民医院 | 一种简化的脐带间充质干细胞分离培养方法及其在类风湿关节炎治疗中的应用 |
CN103860593A (zh) * | 2012-12-11 | 2014-06-18 | 臻景生物技术(上海)有限公司 | 间质血管层细胞和间充质祖细胞在预防或治疗类风湿性关节炎中的应用 |
CN103961374A (zh) * | 2013-02-04 | 2014-08-06 | 西比曼生物科技(上海)有限公司 | 异体间质血管层细胞和异体间充质祖细胞在预防或治疗类风湿性关节炎中的应用 |
CN105833277A (zh) * | 2016-03-29 | 2016-08-10 | 深圳爱生再生医学科技有限公司 | 治疗类风湿性关节炎的干细胞制剂及其制备方法和应用 |
CN106366174A (zh) * | 2016-09-14 | 2017-02-01 | 大连理工大学 | 一种鹿茸多肽在降低间充质干细胞黏附力中的应用 |
-
2018
- 2018-04-23 CN CN201810368844.XA patent/CN108392624B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101643719A (zh) * | 2009-07-27 | 2010-02-10 | 北京大学人民医院 | 一种简化的脐带间充质干细胞分离培养方法及其在类风湿关节炎治疗中的应用 |
CN103860593A (zh) * | 2012-12-11 | 2014-06-18 | 臻景生物技术(上海)有限公司 | 间质血管层细胞和间充质祖细胞在预防或治疗类风湿性关节炎中的应用 |
CN103961374A (zh) * | 2013-02-04 | 2014-08-06 | 西比曼生物科技(上海)有限公司 | 异体间质血管层细胞和异体间充质祖细胞在预防或治疗类风湿性关节炎中的应用 |
CN105833277A (zh) * | 2016-03-29 | 2016-08-10 | 深圳爱生再生医学科技有限公司 | 治疗类风湿性关节炎的干细胞制剂及其制备方法和应用 |
CN106366174A (zh) * | 2016-09-14 | 2017-02-01 | 大连理工大学 | 一种鹿茸多肽在降低间充质干细胞黏附力中的应用 |
Non-Patent Citations (2)
Title |
---|
脐带间充质干细胞与类风湿性关节炎;李铭等人;《西北国防医学杂志》;20120630;第33卷(第3期);第256-258页 * |
间充质干细胞治疗类风湿关节炎的研究进展;杨爱成等;《风湿病与关节炎》;20130728;第2卷(第7期);第67-71页 * |
Also Published As
Publication number | Publication date |
---|---|
CN108392624A (zh) | 2018-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2589311T3 (es) | Poblaciones de células que tienen actividad inmunorreguladora, método de aislamiento y usos | |
KR101723265B1 (ko) | mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 | |
RU2610427C2 (ru) | Способы и композиции для применения в клеточной терапии | |
ES2628362T3 (es) | Tratamiento de la enfermedad de injerto contra hospedador | |
CN106916783B (zh) | 肌肉干细胞体外培养方法及其应用 | |
Yin et al. | A cellular spinal cord scaffold seeded with rat adipose‑derived stem cells facilitates functional recovery via enhancing axon regeneration in spinal cord injured rats | |
Zhang et al. | Combining acellular nerve allografts with brain-derived neurotrophic factor transfected bone marrow mesenchymal stem cells restores sciatic nerve injury better than either intervention alone | |
CN111202751A (zh) | 间充质干细胞在制备治疗类风湿性关节炎的产品中的应用 | |
Khan et al. | Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra‐Synovial Tendinopathy | |
Cao et al. | Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury | |
JP2014156482A (ja) | ケロイド及び肥厚性瘢痕根治治療剤 | |
CN108392624B (zh) | 活性促进肽以及间充质干细胞在治疗类风湿性关节炎中的应用 | |
KR20180009435A (ko) | 지방조직-유래 기질혈관분획의 분리 방법 | |
CN108451981B (zh) | 使用皮肤间充质干细胞治疗系统性硬化症 | |
CN110731969A (zh) | 一种间充质干细胞的制备及在制备疼痛药中的应用 | |
KR20150020112A (ko) | 메트포민이 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 | |
US10751371B2 (en) | Use of allogeneic interstitial vessel-layer cell and allogeneic mesenchymal progenitor cell for preventing or treating osteoarthritis | |
Bērziņš et al. | Characterisation and Safety of Canine Adipose-Derived Stem Cells | |
KR102199048B1 (ko) | 골수 흡인 농축물-혈소판 농축혈장 복합체로 구성된 건병증 예방 또는 치료용 약학적 조성물 | |
CN112294844A (zh) | 多潜能细胞活性物联合富血小板血浆的骨关节炎治疗药物及制法和应用 | |
CN110742906A (zh) | 一种间充质干细胞旁分泌因子在制备疼痛药中的应用 | |
CN108126187A (zh) | 一种组合物和其制备方法 | |
CN103816183A (zh) | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 | |
WO2016141883A1 (zh) | 治疗关节软骨缺损的组合物 | |
CN103860593A (zh) | 间质血管层细胞和间充质祖细胞在预防或治疗类风湿性关节炎中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200730 Address after: 100176 1408, 14th floor, building 1, No.5, Ronghua Middle Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Applicant after: Beijing Northai Research Institute of Regenerative Medicine Co.,Ltd. Address before: 471000 Ludu Yuefu Building 1 Unit 1-1404, South of Qianjiang Road, West of Chang Xiamen Street, Luoyang Economic and Technological Development Zone, Henan Province Applicant before: LUOYANG XUANZHI BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 100176 room 801, 8th floor, building 2, yard 5, Ronghua Middle Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee after: Beijing Daxi Biotechnology Co.,Ltd. Address before: 100176 1408, 14th floor, building 1, yard 5, Ronghua Middle Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: Beijing Northai Research Institute of Regenerative Medicine Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210126 Address after: 100176 room 01-12, 1st floor, building 1, No.3, Yongchang North Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee after: Nuosa Union (Beijing) Biomedical Technology Co.,Ltd. Patentee after: Beijing Daxi Biotechnology Co.,Ltd. Address before: 100176 room 801, 8th floor, building 2, yard 5, Ronghua Middle Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: Beijing Daxi Biotechnology Co.,Ltd. |