CN103787984A - 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 - Google Patents
替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 Download PDFInfo
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- CN103787984A CN103787984A CN201410036122.6A CN201410036122A CN103787984A CN 103787984 A CN103787984 A CN 103787984A CN 201410036122 A CN201410036122 A CN 201410036122A CN 103787984 A CN103787984 A CN 103787984A
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- nitro
- pyrimidine
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- chloro
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- 0 CCCSc(nc1*)nc(*)*1[N+]([O-])=O Chemical compound CCCSc(nc1*)nc(*)*1[N+]([O-])=O 0.000 description 3
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201410036122.6A CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
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CN201410036122.6A CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN103787984A true CN103787984A (zh) | 2014-05-14 |
CN103787984B CN103787984B (zh) | 2015-10-07 |
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CN201410036122.6A Active CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104003943A (zh) * | 2014-05-06 | 2014-08-27 | 南通常佑药业科技有限公司 | 一种替格瑞洛中间体的制备方法 |
CN106496133A (zh) * | 2016-10-19 | 2017-03-15 | 青岛云天生物技术有限公司 | 替卡格雷中间体的制备方法 |
CN110256360A (zh) * | 2019-06-19 | 2019-09-20 | 浙江科技学院 | 一种4,6-二氯-5-硝基-2-(丙巯基)-嘧啶的制备方法 |
CN112920126A (zh) * | 2021-01-13 | 2021-06-08 | 新沂大江化工有限公司 | 一种双草醚中间体2-甲磺酰基4,6-二甲氧基嘧啶的制备方法及制备装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011017108A2 (en) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
WO2011101740A1 (en) * | 2010-02-16 | 2011-08-25 | Actavis Group Ptc Ehf | Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
CN103429576A (zh) * | 2010-12-20 | 2013-12-04 | 阿特维斯集团公司 | 制备三唑并[4,5-d]嘧啶衍生物及其中间体的新方法 |
-
2014
- 2014-01-26 CN CN201410036122.6A patent/CN103787984B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011017108A2 (en) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
WO2011101740A1 (en) * | 2010-02-16 | 2011-08-25 | Actavis Group Ptc Ehf | Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CN103429576A (zh) * | 2010-12-20 | 2013-12-04 | 阿特维斯集团公司 | 制备三唑并[4,5-d]嘧啶衍生物及其中间体的新方法 |
CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
Non-Patent Citations (1)
Title |
---|
TONG-HUI HUANG等: "Synthesis and herbicidal activity of new substituted 2- and 4-pyrimidinyloxyphenoxypropionate derivatives", 《ARKIVOC》, vol. 2011, 14 November 2010 (2010-11-14) * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104003943A (zh) * | 2014-05-06 | 2014-08-27 | 南通常佑药业科技有限公司 | 一种替格瑞洛中间体的制备方法 |
CN106496133A (zh) * | 2016-10-19 | 2017-03-15 | 青岛云天生物技术有限公司 | 替卡格雷中间体的制备方法 |
CN110256360A (zh) * | 2019-06-19 | 2019-09-20 | 浙江科技学院 | 一种4,6-二氯-5-硝基-2-(丙巯基)-嘧啶的制备方法 |
CN110256360B (zh) * | 2019-06-19 | 2020-09-15 | 浙江科技学院 | 一种4,6-二氯-5-硝基-2-(丙巯基)-嘧啶的制备方法 |
CN112920126A (zh) * | 2021-01-13 | 2021-06-08 | 新沂大江化工有限公司 | 一种双草醚中间体2-甲磺酰基4,6-二甲氧基嘧啶的制备方法及制备装置 |
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Publication number | Publication date |
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CN103787984B (zh) | 2015-10-07 |
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Effective date of registration: 20201124 Address after: 215000 No. 68, Hu Qing Road, Hu Guan Guan, hi tech Zone, Suzhou, Jiangsu Patentee after: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. Address before: Xushuguan town Hu celadon road high tech Industry Development Zone of Suzhou City, Jiangsu province 215000 No. 68 Patentee before: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. Patentee before: Xu Xuenong |
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Address after: 215000 68 Huqing Road, Hushuguan Town, high tech Zone, Suzhou City, Jiangsu Province Patentee after: Suzhou Teri Pharmaceutical Co.,Ltd. Address before: 215000 68 Huqing Road, Hushuguan Town, high tech Zone, Suzhou City, Jiangsu Province Patentee before: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. |
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