CN103787984B - 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 - Google Patents
替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 Download PDFInfo
- Publication number
- CN103787984B CN103787984B CN201410036122.6A CN201410036122A CN103787984B CN 103787984 B CN103787984 B CN 103787984B CN 201410036122 A CN201410036122 A CN 201410036122A CN 103787984 B CN103787984 B CN 103787984B
- Authority
- CN
- China
- Prior art keywords
- nitro
- pyrimidine
- chloro
- bis
- ticagrelor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CCCSC(NC1N(C(CC([C@@]2O)=*CC*)[C@@]2O)N=NC11)N=C1N[C@](C1)[C@]1c(cc1F)ccc1F Chemical compound CCCSC(NC1N(C(CC([C@@]2O)=*CC*)[C@@]2O)N=NC11)N=C1N[C@](C1)[C@]1c(cc1F)ccc1F 0.000 description 2
- GOLWDTATIOZEKT-UHFFFAOYSA-N CCCSC(NCCC1Cl)NC(Cl)=C1N=O Chemical compound CCCSC(NCCC1Cl)NC(Cl)=C1N=O GOLWDTATIOZEKT-UHFFFAOYSA-N 0.000 description 1
- YCTBVUASEBILRT-UHFFFAOYSA-O CCCSc(nc1N)nc2c1[NH2+]N2C(C1)C2OC(C)(C)OC2C1OCC(OC)=O Chemical compound CCCSc(nc1N)nc2c1[NH2+]N2C(C1)C2OC(C)(C)OC2C1OCC(OC)=O YCTBVUASEBILRT-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410036122.6A CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410036122.6A CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103787984A CN103787984A (zh) | 2014-05-14 |
CN103787984B true CN103787984B (zh) | 2015-10-07 |
Family
ID=50664092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410036122.6A Active CN103787984B (zh) | 2014-01-26 | 2014-01-26 | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103787984B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104003943A (zh) * | 2014-05-06 | 2014-08-27 | 南通常佑药业科技有限公司 | 一种替格瑞洛中间体的制备方法 |
CN106496133A (zh) * | 2016-10-19 | 2017-03-15 | 青岛云天生物技术有限公司 | 替卡格雷中间体的制备方法 |
CN110256360B (zh) * | 2019-06-19 | 2020-09-15 | 浙江科技学院 | 一种4,6-二氯-5-硝基-2-(丙巯基)-嘧啶的制备方法 |
CN112920126A (zh) * | 2021-01-13 | 2021-06-08 | 新沂大江化工有限公司 | 一种双草醚中间体2-甲磺酰基4,6-二甲氧基嘧啶的制备方法及制备装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011017108A2 (en) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
WO2011101740A1 (en) * | 2010-02-16 | 2011-08-25 | Actavis Group Ptc Ehf | Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
CN103429576A (zh) * | 2010-12-20 | 2013-12-04 | 阿特维斯集团公司 | 制备三唑并[4,5-d]嘧啶衍生物及其中间体的新方法 |
-
2014
- 2014-01-26 CN CN201410036122.6A patent/CN103787984B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011017108A2 (en) * | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
WO2011101740A1 (en) * | 2010-02-16 | 2011-08-25 | Actavis Group Ptc Ehf | Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
CN103429576A (zh) * | 2010-12-20 | 2013-12-04 | 阿特维斯集团公司 | 制备三唑并[4,5-d]嘧啶衍生物及其中间体的新方法 |
CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
Non-Patent Citations (1)
Title |
---|
Synthesis and herbicidal activity of new substituted 2- and 4-pyrimidinyloxyphenoxypropionate derivatives;Tong-Hui Huang等;《ARKIVOC》;20101114;第2011卷(第ii期);第4页流程图2、第10-11页 * |
Also Published As
Publication number | Publication date |
---|---|
CN103787984A (zh) | 2014-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9850244B2 (en) | Method for preparing Palbociclib | |
CN103787984B (zh) | 替格瑞洛中间体4,6-二氯-5-硝基-2-(丙硫基)嘧啶的制备方法 | |
US9969718B2 (en) | Preparation method for Bemaciclb | |
CN103772295B (zh) | 替格瑞洛中间体4,6-二氯-2-(丙巯基)-5-氨基嘧啶的制备方法 | |
CN104926736A (zh) | 一种嘧菌酯及其中间体的合成方法 | |
Lim et al. | A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo [1, 5-a][1, 3, 5] triazine-8-carbonitriles | |
US10005726B2 (en) | Ribociclib intermediate and preparation method therefor | |
Alam et al. | CO bond formation in a microfluidic reactor: high yield SNAr substitution of heteroaryl chlorides | |
CN104926798A (zh) | 阿法替尼中间体的高纯度制备方法 | |
CN105646373A (zh) | 一种4-氨基-2,6-二甲氧基嘧啶的制备方法 | |
CN102167716A (zh) | 氯法拉滨的合成方法及其中间体和中间体的制备方法 | |
CN102250016B (zh) | 一种4,5,6-三氯嘧啶的制备方法 | |
CN103415510B (zh) | 氨苯基嘧啶基醇衍生物的制备方法及其合成中间体 | |
CN104974097A (zh) | 一种嘧菌酯的合成方法 | |
CN106831599B (zh) | 一种合成1-二氟甲基咪唑及其衍生物的方法 | |
CN104557877B (zh) | 一种阿伐那非中间体及其制备方法和应用 | |
CN104003943A (zh) | 一种替格瑞洛中间体的制备方法 | |
CN104447736B (zh) | 一种veranamine的合成方法 | |
CN108484508A (zh) | 一种5-三氟甲基尿嘧啶的合成方法 | |
CN103787987B (zh) | 替格瑞洛中间体的制备方法 | |
CN105218463A (zh) | 吉非替尼的合成方法 | |
CN106496133A (zh) | 替卡格雷中间体的制备方法 | |
CN104230818A (zh) | 替卡格雷中间体的改进制备方法 | |
CN105601574A (zh) | 一种制备2-氨基-4,6-二甲氧基嘧啶的方法 | |
CN107286165B (zh) | 合成色胺酮类化合物的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201124 Address after: 215000 No. 68, Hu Qing Road, Hu Guan Guan, hi tech Zone, Suzhou, Jiangsu Patentee after: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. Address before: Xushuguan town Hu celadon road high tech Industry Development Zone of Suzhou City, Jiangsu province 215000 No. 68 Patentee before: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. Patentee before: Xu Xuenong |
|
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 215000 68 Huqing Road, Hushuguan Town, high tech Zone, Suzhou City, Jiangsu Province Patentee after: Suzhou Teri Pharmaceutical Co.,Ltd. Address before: 215000 68 Huqing Road, Hushuguan Town, high tech Zone, Suzhou City, Jiangsu Province Patentee before: SUZHOU TERUI PHARMACEUTICAL Co.,Ltd. |