CN103687955B - 分离方法 - Google Patents

分离方法 Download PDF

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Publication number
CN103687955B
CN103687955B CN201280035003.8A CN201280035003A CN103687955B CN 103687955 B CN103687955 B CN 103687955B CN 201280035003 A CN201280035003 A CN 201280035003A CN 103687955 B CN103687955 B CN 103687955B
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CN
China
Prior art keywords
lactide
lactic acid
aliphatic alcohol
alcohol ester
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280035003.8A
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English (en)
Chinese (zh)
Other versions
CN103687955A (zh
Inventor
爱德华·莱斯利·马歇尔
杰德·约瑟琳·阿夫里耶·奥赛伊-图图
斯蒂芬·亚历山大·贾德尔·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plaxica Ltd
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Plaxica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201112296A external-priority patent/GB201112296D0/en
Priority claimed from GB201112297A external-priority patent/GB201112297D0/en
Priority claimed from GB201210275A external-priority patent/GB201210275D0/en
Application filed by Plaxica Ltd filed Critical Plaxica Ltd
Publication of CN103687955A publication Critical patent/CN103687955A/zh
Application granted granted Critical
Publication of CN103687955B publication Critical patent/CN103687955B/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CN201280035003.8A 2011-07-15 2012-07-16 分离方法 Active CN103687955B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB201112296A GB201112296D0 (en) 2011-07-15 2011-07-15 Separation process
GB1112297.5 2011-07-15
GB201112297A GB201112297D0 (en) 2011-07-15 2011-07-15 Separation process
GB1112296.7 2011-07-15
GB1210275.2 2012-06-11
GB201210275A GB201210275D0 (en) 2012-06-11 2012-06-11 Lactate production process
PCT/GB2012/051695 WO2013011295A1 (en) 2011-07-15 2012-07-16 Separation process

Publications (2)

Publication Number Publication Date
CN103687955A CN103687955A (zh) 2014-03-26
CN103687955B true CN103687955B (zh) 2016-05-11

Family

ID=46582015

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201280034985.9A Active CN103649324B (zh) 2011-07-15 2012-07-16 分离方法
CN201280035003.8A Active CN103687955B (zh) 2011-07-15 2012-07-16 分离方法
CN201280034935.0A Active CN103649323B (zh) 2011-07-15 2012-07-16 分离方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201280034985.9A Active CN103649324B (zh) 2011-07-15 2012-07-16 分离方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280034935.0A Active CN103649323B (zh) 2011-07-15 2012-07-16 分离方法

Country Status (11)

Country Link
US (3) US9045781B2 (enExample)
EP (3) EP2732043A2 (enExample)
JP (3) JP2014521601A (enExample)
KR (2) KR20140053129A (enExample)
CN (3) CN103649324B (enExample)
AU (2) AU2012285565B2 (enExample)
BR (3) BR112014000848B1 (enExample)
CA (2) CA2841929A1 (enExample)
ES (1) ES2684506T3 (enExample)
WO (3) WO2013011298A1 (enExample)
ZA (3) ZA201309692B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014000848B1 (pt) * 2011-07-15 2021-03-09 Plaxica Limited processo de produção de um éster alifático de ácido lático e um éster alifático de ácido lactil-láctico
GB201311780D0 (en) * 2013-07-01 2013-08-14 Plaxica Ltd Lactate production process
GB201322785D0 (en) 2013-12-20 2014-02-05 Solvert Ltd Manufacture of lactic acid
CN111118073B (zh) * 2019-12-27 2022-02-15 宜昌东阳光生化制药有限公司 酶法合成依米他韦中间体的方法
WO2022260430A1 (ko) * 2021-06-10 2022-12-15 주식회사 엘지화학 락타이드 라세미체의 분리방법
CN116724029A (zh) * 2021-06-10 2023-09-08 株式会社Lg化学 外消旋丙交酯的分离方法
KR102851969B1 (ko) * 2021-06-10 2025-08-28 주식회사 엘지화학 락타이드 라세미체의 분리방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2371281A (en) * 1945-03-13 Lactyuactic esters and process of
CN1112559A (zh) * 1993-12-08 1995-11-29 株式会社武藏野化学研究所 丙交酯的提纯方法

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US2610196A (en) * 1950-03-27 1952-09-09 Charles H Fisher Esters of acylated hydroxycarboxylic acids
US4835293A (en) * 1987-02-24 1989-05-30 E. I. Du Pont De Nemours And Company Atmospheric pressure process for preparing pure cyclic esters
US5274127A (en) * 1990-09-18 1993-12-28 Biopak Technology, Ltd. Lactide production from dehydration of aqueous lactic acid feed
US6005067A (en) 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
JP3502419B2 (ja) * 1993-03-02 2004-03-02 株式会社武蔵野化学研究所 乳酸および乳酸エステルの製造方法
JP2560259B2 (ja) * 1994-10-21 1996-12-04 工業技術院長 ラクチドの製造方法
JP2002030523A (ja) * 2000-07-14 2002-01-31 Toray Ind Inc ポリ乳酸繊維
WO2004081220A2 (en) 2003-03-07 2004-09-23 Novus International Inc. A process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids
KR100622280B1 (ko) 2004-04-27 2006-09-18 한국화학연구원 리파제를 이용한 알킬 에스-(엘)-락테이트 및 알킬알-(디)-오-아실락테이트의 제조방법
KR100592794B1 (ko) 2005-01-06 2006-06-28 한국화학연구원 리파제를 이용하여 락타이드로부터 알킬 락테이트를제조하는 방법
WO2007001043A1 (ja) * 2005-06-29 2007-01-04 Hitachi Zosen Corporation 乳酸の製造方法および乳酸製造装置
ES2645238T3 (es) * 2006-07-06 2017-12-04 Stepan Company Composición de cuidado personal
JP2008206402A (ja) * 2007-02-23 2008-09-11 Ccy:Kk 乳酸エステルの製造方法
JP2009144258A (ja) * 2007-12-11 2009-07-02 Teijin Fibers Ltd ポリ乳酸直接延伸糸およびその製造方法
JP2009142217A (ja) * 2007-12-14 2009-07-02 Tohoku Biomass Giken:Kk 酵素による乳酸エステルの合成法
JP5169294B2 (ja) 2008-02-20 2013-03-27 ダイソー株式会社 乳酸エステルを光学分割する方法
KR101012483B1 (ko) 2008-07-08 2011-02-09 김용환 효소 전환반응을 이용한 광학순수형 락티드 제조방법 및광학순수형 유산 또는 알킬 락테이트의 분리방법
UA108835C2 (uk) 2008-08-29 2015-06-25 Спосіб отримання суміші похідних лактиду
EP2406245B1 (en) 2009-03-13 2014-01-08 NatureWorks LLC Recovery of lactic acid values from a meso-lactide stream
KR101154029B1 (ko) * 2009-05-20 2012-06-07 한국화학연구원 젖산에스테르로부터 락타이드의 직접 전환용 촉매 및 이를 이용한 락타이드의 제조방법
GB2484674A (en) 2010-10-18 2012-04-25 Plaxica Ltd Process for producing a lactic acid-amine complex
BR112014000848B1 (pt) * 2011-07-15 2021-03-09 Plaxica Limited processo de produção de um éster alifático de ácido lático e um éster alifático de ácido lactil-láctico

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2371281A (en) * 1945-03-13 Lactyuactic esters and process of
CN1112559A (zh) * 1993-12-08 1995-11-29 株式会社武藏野化学研究所 丙交酯的提纯方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Synthesis of alkyl (R)-lactates and alkyl (S,S)-O-lactyllactates by alcoholysis of rac-lactide using Novozym 435;Nan Young Jeon et al.;《TETRAHEDRON LETTERS》;20060911;第47卷(第37期);摘要，第6517页右栏第2段，第6518页图1、表1，第6519页表2 *
丙交酯的合成新工艺研究;王浩;《万方学术》;20041021;第50页第1段 *
葡萄糖月桂酸酯的酶法合成与分离测定;李霞等;《食品工业科技》;20080514;第29卷(第2期);239-242 *

Also Published As

Publication number Publication date
US20140147898A1 (en) 2014-05-29
ES2684506T3 (es) 2018-10-03
NZ619106A (en) 2015-08-28
CN103687955A (zh) 2014-03-26
CA2841929A1 (en) 2013-01-24
BR112014000848A2 (pt) 2017-02-21
JP2014522652A (ja) 2014-09-08
US20140141475A1 (en) 2014-05-22
AU2012285562B2 (en) 2015-09-17
EP2732041A1 (en) 2014-05-21
CN103649324A (zh) 2014-03-19
BR112014000848B1 (pt) 2021-03-09
BR112014000885A2 (pt) 2017-02-21
CN103649324B (zh) 2016-05-25
EP2732042A1 (en) 2014-05-21
AU2012285565A1 (en) 2014-01-16
AU2012285565B2 (en) 2015-09-17
WO2013011296A2 (en) 2013-01-24
BR112014000885B1 (pt) 2020-12-01
BR112014000901A2 (pt) 2017-02-21
ZA201309691B (en) 2014-08-27
EP2732043A2 (en) 2014-05-21
US9045781B2 (en) 2015-06-02
WO2013011296A3 (en) 2013-07-25
CN103649323A (zh) 2014-03-19
CA2841930A1 (en) 2013-01-24
WO2013011295A1 (en) 2013-01-24
ZA201309692B (en) 2014-08-27
NZ619163A (en) 2015-08-28
KR20140053129A (ko) 2014-05-07
AU2012285562A1 (en) 2014-01-16
CN103649323B (zh) 2016-05-25
US9045782B2 (en) 2015-06-02
ZA201400119B (en) 2015-06-24
US9045783B2 (en) 2015-06-02
US20140342413A1 (en) 2014-11-20
EP2732041B1 (en) 2018-04-11
WO2013011298A1 (en) 2013-01-24
KR20140077877A (ko) 2014-06-24
JP6340496B2 (ja) 2018-06-13
JP2014522651A (ja) 2014-09-08
JP2014521601A (ja) 2014-08-28
BR112014000901B1 (pt) 2021-02-02

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