CN103687590A - 用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法 - Google Patents

用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法 Download PDF

Info

Publication number
CN103687590A
CN103687590A CN201280031496.8A CN201280031496A CN103687590A CN 103687590 A CN103687590 A CN 103687590A CN 201280031496 A CN201280031496 A CN 201280031496A CN 103687590 A CN103687590 A CN 103687590A
Authority
CN
China
Prior art keywords
cell
protocell
inhibitors
cancer
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280031496.8A
Other languages
English (en)
Chinese (zh)
Inventor
J·C·布林克
E·C·卡恩斯
C·E·艾什莉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Technology and Engineering Solutions of Sandia LLC
UNM Rainforest Innovations
Original Assignee
STC UNM
Sandia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STC UNM, Sandia Corp filed Critical STC UNM
Publication of CN103687590A publication Critical patent/CN103687590A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
CN201280031496.8A 2011-04-28 2012-04-27 用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法 Pending CN103687590A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161479847P 2011-04-28 2011-04-28
US61/479,847 2011-04-28
PCT/US2012/035529 WO2012149376A2 (en) 2011-04-28 2012-04-27 Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

Publications (1)

Publication Number Publication Date
CN103687590A true CN103687590A (zh) 2014-03-26

Family

ID=47073093

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280031496.8A Pending CN103687590A (zh) 2011-04-28 2012-04-27 用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法

Country Status (7)

Country Link
US (3) US9579283B2 (https=)
EP (1) EP2701686A4 (https=)
JP (1) JP2014512409A (https=)
CN (1) CN103687590A (https=)
AU (1) AU2012249474A1 (https=)
CA (1) CA2834365A1 (https=)
WO (1) WO2012149376A2 (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104023711A (zh) * 2011-10-14 2014-09-03 Stc.Unm公司 用于靶向递送(包括负载物的透皮递送)的多孔纳米颗粒支撑的脂质双层(原始细胞)及其方法
CN104667290A (zh) * 2014-10-25 2015-06-03 中国科学技术大学 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用
CN105456198A (zh) * 2015-12-25 2016-04-06 正大天晴药业集团股份有限公司 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法
CN107920964A (zh) * 2015-07-09 2018-04-17 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
CN108367076A (zh) * 2015-10-22 2018-08-03 德尔科技有限公司 水凝胶复合材料药性持久制剂
CN108938595A (zh) * 2018-07-15 2018-12-07 河南工业大学 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法
CN110120249A (zh) * 2019-05-23 2019-08-13 复旦大学 通过靶向调控动力学路径构造靶向构造目标结构的方法
CN111991558A (zh) * 2020-08-28 2020-11-27 安徽贝克生物制药有限公司 一种抗逆转录病毒药物组合物及其制备方法
CN112480212A (zh) * 2020-12-17 2021-03-12 中国药科大学 靶向肝细胞生长因子的高亲和肽及其应用
CN113616618A (zh) * 2017-09-22 2021-11-09 杭州景杰生物科技有限公司 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒
CN114949250A (zh) * 2016-04-14 2022-08-30 斯宾纳克生物科学公司 用于递送治疗剂的组合物、药物组合物、制备方法以及用途
US20230321032A1 (en) * 2022-04-06 2023-10-12 University Of Kentucky Research Foundation Functionalized mesoporous silica nanoparticles for treatment of periodontal disease
CN120504733A (zh) * 2025-03-28 2025-08-19 江南大学 一种用于骨折修复的生物合成类i型胶原蛋白水凝胶及其制备方法

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2599630T3 (es) * 2006-09-28 2017-02-02 Hadasit Medical Research Services & Development Limited Uso de glicerofosfolípidos para lubricación de las articulaciones
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
AU2012249474A1 (en) * 2011-04-28 2013-11-07 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
CN103857387B (zh) * 2011-06-02 2017-03-15 加利福尼亚大学董事会 膜包封的纳米颗粒及使用方法
BR112014001346A8 (pt) 2011-07-19 2018-05-08 Stc Unm composto nanotransportador, método, composto farmacêutico e uso de um composto
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
WO2013103614A1 (en) * 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9273305B1 (en) 2012-04-25 2016-03-01 Sandia Corporation Cell-based composite materials with programmed structures and functions
ES2821528T3 (es) 2012-11-14 2021-04-26 Grace W R & Co Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US20160008399A1 (en) 2013-01-14 2016-01-14 Fred Hutchinson Cancer Research Center Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
EP4378461A3 (en) * 2013-03-05 2024-09-11 The Regents of University of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
EP2968191B1 (en) 2013-03-14 2021-06-16 Abraxis BioScience, LLC Methods of treating bladder cancer
US9603799B2 (en) 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
US20140271815A1 (en) * 2013-03-15 2014-09-18 Aryo Sorayya Heat-and freeze-stable vaccines and methods of making and using same
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US20160151482A1 (en) * 2013-04-02 2016-06-02 Stc. Unm Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery
CN103989631A (zh) * 2013-04-15 2014-08-20 中国人民解放军第二军医大学 萝卜硫素制剂及其制备方法和应用
CN103990130A (zh) * 2013-06-24 2014-08-20 中国人民解放军第二军医大学 介孔二氧化硅纳米制剂及其制备方法和应用
US10272137B2 (en) 2013-06-27 2019-04-30 The Board Of Regents Of The University Of Texas System Compositions and methods relating to myomaker-induced muscle cell fusion
WO2015042268A1 (en) * 2013-09-18 2015-03-26 Stc.Unm Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
SG10201912038TA (en) 2014-04-23 2020-02-27 Modernatx Inc Nucleic acid vaccines
EP3173074A4 (en) 2014-07-22 2018-03-07 Lemonex Inc. Composition for delivering bioactive material or protein, and use thereof
US20160090603A1 (en) * 2014-09-30 2016-03-31 Sandia Corporation Delivery platforms for the domestication of algae and plants
WO2016205515A1 (en) * 2015-06-17 2016-12-22 The Curators Of The University Of Missouri GOLD NANOROD BASED DIAGNOSTIC AGENT FOR DETECTION AND QUANTIFICATION OF c-MET (HGF) RECEPTORS
LU92784B1 (en) * 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector
LU92783B1 (en) * 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Highly aminated self-assembling fuctionalized Mesoporous Silicia Nanoparticles and methods of synthesis
WO2017020026A1 (en) 2015-07-30 2017-02-02 Modernatx, Inc. Concatemeric peptide epitopes rnas
JP2017038539A (ja) * 2015-08-18 2017-02-23 日本電信電話株式会社 脂質二分子膜基板
US20190262469A1 (en) * 2015-09-04 2019-08-29 C. Jeffrey Brinker Protocells to treat microbial infection and for synergistic delivery
WO2017041033A1 (en) * 2015-09-04 2017-03-09 Brinker C Jeffrey Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications
EP4286012A3 (en) 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US10016422B2 (en) * 2015-09-30 2018-07-10 Oregon State University Nanocarrier drug delivery platform
EP3364949A4 (en) 2015-10-22 2019-07-31 ModernaTX, Inc. CANCER VACCINES
HUE057877T2 (hu) 2015-12-22 2022-06-28 Modernatx Inc Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására
US11696959B2 (en) 2015-12-31 2023-07-11 City Of Hope Nanoparticle-cell construct with platinum anti-cancer agent
US11672866B2 (en) * 2016-01-08 2023-06-13 Paul N. DURFEE Osteotropic nanoparticles for prevention or treatment of bone metastases
CN108601746B (zh) 2016-01-08 2024-09-13 加利福尼亚大学董事会 用于运载物递送的具有脂质双层包衣的中孔二氧化硅纳米颗粒
US20190298681A1 (en) * 2016-03-16 2019-10-03 Merrimack Pharmaceuticals, Inc. Nanoliposomal Targeting of Ephrin Receptor A2 (Epha2) and Related Diagnostics
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
US10663450B2 (en) * 2016-06-15 2020-05-26 The University Of Chicago Amorphous, porous silicon materials and related methods
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
US20190336532A1 (en) * 2016-12-21 2019-11-07 Fred Hutchinson Cancer Research Center Scaffolds to treat solid tumor cells and escape variants
US10874768B2 (en) * 2017-01-20 2020-12-29 Covidien Lp Drug eluting medical device
KR20180091768A (ko) 2017-02-06 2018-08-16 주식회사 레모넥스 생리활성물질 전달체
WO2018160865A1 (en) 2017-03-01 2018-09-07 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
US11969506B2 (en) 2017-03-15 2024-04-30 Modernatx, Inc. Lipid nanoparticle formulation
WO2018170322A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Crystal forms of amino lipids
SMT202300097T1 (it) 2017-03-15 2023-05-12 Modernatx Inc Composto e composizioni per il rilascio intracellulare di agenti terapeutici
WO2018187287A1 (en) * 2017-04-03 2018-10-11 Charles Jeffrey Brinker Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators
WO2018187590A1 (en) 2017-04-05 2018-10-11 Modernatx, Inc. Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
AU2018266111B2 (en) * 2017-05-08 2024-11-07 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
US12077501B2 (en) 2017-06-14 2024-09-03 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
US11007516B1 (en) 2017-06-19 2021-05-18 National Technology & Engineering Solutions Of Sandia, Llc Tunable metal-organic framework compositions and methods thereof
WO2019005830A1 (en) * 2017-06-26 2019-01-03 Fordoz Pharma Corp. NANOSOME FORMULATIONS OF APREPITANT AND METHODS AND APPLICATIONS THEREOF
US20200163885A1 (en) * 2017-07-25 2020-05-28 Lemonex Inc. Composition for delivering physiologically active ingredients into blood vessel
WO2019046809A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. METHODS OF MANUFACTURING LIPID NANOPARTICLES
KR102152348B1 (ko) 2017-09-05 2020-09-08 주식회사 레모넥스 세포 운명 조절용 조성물
US10933027B1 (en) 2017-09-25 2021-03-02 National Technology & Engineering Solutions Of Sandia, Llc Expanded pore particles and delivery methods thereof
US12383499B2 (en) 2018-01-01 2025-08-12 The Regents Of The University Of California Scale up synthesis of silicasome nanocarriers
WO2019169152A1 (en) * 2018-02-28 2019-09-06 Noureddine Achraf Starry mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles
EP3814765A4 (en) * 2018-05-08 2022-06-01 Yale University PROTEIN UPtake MEMBRANE AND METHODS OF USE THEREOF
US11045554B1 (en) * 2018-06-22 2021-06-29 National Technology & Engineering Solutions Of Sandia, Llc Lipid-coated particles for treating viral infections
EP3820509A1 (en) 2018-07-09 2021-05-19 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
US12263248B2 (en) 2018-09-19 2025-04-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
CN113271926A (zh) 2018-09-20 2021-08-17 摩登纳特斯有限公司 脂质纳米颗粒的制备及其施用方法
WO2020068798A1 (en) 2018-09-24 2020-04-02 Guo Jimin Living mammalian cells modified with functional modular nanoparticles
EP3880832A1 (en) * 2018-11-14 2021-09-22 Flagship Pioneering Innovations V, Inc. Fusosome compositions for hematopoietic stem cell delivery
US12496274B2 (en) 2018-11-14 2025-12-16 Flagship Pioneering Innovations V, Inc. Compositions and methods for compartment-specific cargo delivery
US12208164B2 (en) 2019-02-28 2025-01-28 Unm Rainforest Innovations Modular metal-organic polyhedra superassembly compositions
EP3938379A4 (en) 2019-03-15 2023-02-22 ModernaTX, Inc. Hiv rna vaccines
BR112022004936A2 (pt) 2019-09-19 2022-06-14 Modernatx Inc Compostos lipídicos contendo carbonato e composições para distribuição intracelular de agentes terapêuticos
AU2020350759A1 (en) 2019-09-19 2022-03-31 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
CN111529504B (zh) * 2020-03-25 2023-01-10 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
CN111529505B (zh) * 2020-03-25 2023-04-11 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
US11433121B1 (en) 2020-04-03 2022-09-06 National Technology & Engineering Solutions Of Sandia, Llc Lipid composition for the delivery of therapeutic cargos
CN111588704B (zh) * 2020-07-01 2023-04-11 西安组织工程与再生医学研究所 靶向响应性释放系统及其制备方法和应用
CN112168977A (zh) * 2020-10-27 2021-01-05 西南大学 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用
IL307544A (en) 2021-04-08 2023-12-01 Sana Biotechnology Inc Cd8-specific antibody constructs and compositions thereof
US12194458B2 (en) * 2022-08-16 2025-01-14 Nicole Shamayev Device and method of portable drug testing
US12098200B1 (en) 2022-10-12 2024-09-24 National Technology & Engineering Solutions Of Sandia, Llc Brain-targeting single domain antibodies and purification methods
WO2024182425A1 (en) * 2023-02-27 2024-09-06 Noureddine Achraf Compositions and methods for treating metabolic diseases/disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5820879A (en) 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
ATE209887T1 (de) 1993-04-02 2001-12-15 Anticancer Inc Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
IL142869A0 (en) * 1998-11-13 2002-03-10 Cyclacel Ltd Transport vectors
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
GB0104259D0 (en) * 2001-02-21 2001-04-11 Smithkline Beecham Biolog Novel compounds
WO2003016040A1 (en) 2001-04-16 2003-02-27 The Regents Of The University Of California Membrane mimetic architectures on nanoporous materials
US20060177495A1 (en) 2001-12-21 2006-08-10 Christine Allen Polymer-lipid delivery vehicles
US20040005352A1 (en) 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
KR20070110084A (ko) 2005-02-14 2007-11-15 오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션 층상 나노입자
US7514267B1 (en) 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
EP1954714A2 (en) 2005-11-10 2008-08-13 Receptor Biologix, Inc. Hepatocyte growth factor intron fusion proteins
US20080160313A1 (en) * 2006-04-26 2008-07-03 Gabriel Lopez Lipid bilayers on nanotextured solid surfaces
CA2657946A1 (en) 2006-06-09 2007-12-13 Protox Therapeutics Incorporated Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease
WO2008024427A2 (en) 2006-08-23 2008-02-28 Science & Technology Corporation @ Unm A virus-like platform for rapid vaccine discovery
EP2099496A2 (en) 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
US20080279764A1 (en) 2007-03-09 2008-11-13 Anthony Manganaro Method and composition for treating cancer
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
US20110105995A1 (en) 2008-01-16 2011-05-05 Zhu Ting F Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery
CA2722183C (en) 2008-04-25 2018-09-18 Northwestern University Nanostructures suitable for sequestering cholesterol and other molecules
US9732324B2 (en) 2008-10-23 2017-08-15 Cornell University Anti-viral method
US20110230372A1 (en) 2008-11-14 2011-09-22 Stc Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric b-precursor acute lymphoblastic leukemia
WO2010078569A2 (en) * 2009-01-05 2010-07-08 Stc.Unm Porous nanoparticle supported lipid bilayer nanostructures
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
US20130017210A1 (en) 2010-03-17 2013-01-17 Stc.Unm Display of antibody fragments on virus-like particles of rna bacteriophages
US20110300186A1 (en) 2010-04-14 2011-12-08 Battelle Memorial Institute Functionalized Nano- and Micro-materials for Medical Therapies
AU2012249474A1 (en) 2011-04-28 2013-11-07 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
BR112014001346A8 (pt) 2011-07-19 2018-05-08 Stc Unm composto nanotransportador, método, composto farmacêutico e uso de um composto
JP2014532071A (ja) 2011-10-14 2014-12-04 エスティーシー． ユーエヌエムＳｔｃ．Ｕｎｍ カーゴの経皮送達を含む標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその方法
WO2013103614A1 (en) 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
US20160151482A1 (en) 2013-04-02 2016-06-02 Stc. Unm Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery
WO2014165608A1 (en) 2013-04-02 2014-10-09 Stc. Unm Antibiotic protocells and related pharmaceutical formulations and methods of treatment
EP3046543A1 (en) 2013-09-18 2016-07-27 Stc.Unm Torroidal mesoporous silica nanoparticles (tmsnps) and related protocells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARLEE E. ASHLEY ET.AL: "The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers", 《NATURE MATERIALS》, vol. 10, 17 April 2011 (2011-04-17), pages 389 - 397, XP055132474, DOI: 10.1038/nmat2992 *
JUEWEN LIU ET.AL: "Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles", 《J AM CHEM SOC》, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1354 - 1355, XP055029872, DOI: 10.1021/ja808018y *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104023711A (zh) * 2011-10-14 2014-09-03 Stc.Unm公司 用于靶向递送(包括负载物的透皮递送)的多孔纳米颗粒支撑的脂质双层(原始细胞)及其方法
CN104667290A (zh) * 2014-10-25 2015-06-03 中国科学技术大学 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用
CN107920964B (zh) * 2015-07-09 2022-02-25 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
US12605336B2 (en) 2015-07-09 2026-04-21 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
CN114533898B (zh) * 2015-07-09 2025-07-01 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
CN107920964A (zh) * 2015-07-09 2018-04-17 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
US11406597B2 (en) 2015-07-09 2022-08-09 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
CN114533898A (zh) * 2015-07-09 2022-05-27 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
CN108367076A (zh) * 2015-10-22 2018-08-03 德尔科技有限公司 水凝胶复合材料药性持久制剂
CN108367076B (zh) * 2015-10-22 2021-08-31 德尔科技有限公司 水凝胶复合材料药性持久制剂
CN105456198B (zh) * 2015-12-25 2017-04-26 正大天晴药业集团股份有限公司 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法
CN105456198A (zh) * 2015-12-25 2016-04-06 正大天晴药业集团股份有限公司 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法
CN114949250A (zh) * 2016-04-14 2022-08-30 斯宾纳克生物科学公司 用于递送治疗剂的组合物、药物组合物、制备方法以及用途
CN113616618A (zh) * 2017-09-22 2021-11-09 杭州景杰生物科技有限公司 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒
CN108938595B (zh) * 2018-07-15 2021-09-14 河南工业大学 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法
CN108938595A (zh) * 2018-07-15 2018-12-07 河南工业大学 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法
CN110120249A (zh) * 2019-05-23 2019-08-13 复旦大学 通过靶向调控动力学路径构造靶向构造目标结构的方法
CN111991558A (zh) * 2020-08-28 2020-11-27 安徽贝克生物制药有限公司 一种抗逆转录病毒药物组合物及其制备方法
CN112480212A (zh) * 2020-12-17 2021-03-12 中国药科大学 靶向肝细胞生长因子的高亲和肽及其应用
US20230321032A1 (en) * 2022-04-06 2023-10-12 University Of Kentucky Research Foundation Functionalized mesoporous silica nanoparticles for treatment of periodontal disease
CN120504733A (zh) * 2025-03-28 2025-08-19 江南大学 一种用于骨折修复的生物合成类i型胶原蛋白水凝胶及其制备方法

Also Published As

Publication number Publication date
US20140079774A1 (en) 2014-03-20
US10022327B2 (en) 2018-07-17
CA2834365A1 (en) 2012-11-01
US9579283B2 (en) 2017-02-28
WO2012149376A3 (en) 2013-01-17
WO2012149376A2 (en) 2012-11-01
AU2012249474A1 (en) 2013-11-07
US20160106671A1 (en) 2016-04-21
JP2014512409A (ja) 2014-05-22
EP2701686A2 (en) 2014-03-05
US20190091150A1 (en) 2019-03-28
EP2701686A4 (en) 2014-11-05

Similar Documents

Publication Publication Date Title
CN103687590A (zh) 用于靶向给药的多孔纳米颗粒支撑脂双层（原始细胞）及其使用方法
Xia et al. Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer
US20150272885A1 (en) Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
US20200197536A1 (en) Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators
US20180110831A1 (en) Cd 47 containing porous nanoparticle supported lipid bilayers (protocells) field of the invention
US20200375912A1 (en) Liposomal coated nanoparticles for immunotherapy applications
CN108601746A (zh) 用于运载物递送的具有脂质双层包衣的中孔二氧化硅纳米颗粒
JP2014532071A5 (https=)
Salzano et al. Transferrin-targeted nanoparticles containing zoledronic acid as a potential tool to inhibit glioblastoma growth
JP5436650B1 (ja) スーパーアパタイト超微細ナノ粒子
Li et al. Nanoparticle binding to urokinase receptor on cancer cell surface triggers nanoparticle disintegration and cargo release
Wu et al. Combined biomimetic MOF-RVG15 nanoformulation efficient over BBB for effective anti-glioblastoma in mice model
Kim et al. Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA
Yao et al. Nucleic acid nanomaterials-based therapy for osteoarthritis: Progress and prospects
EP3936121A1 (en) Self assembling molecules for targeted drug delivery
Warthen et al. Peptides as targeting agents and therapeutics: a brief overview
Yang et al. Co-delivery of paclitaxel and doxorubicin using polypeptide-engineered nanogels for combination therapy of tumor
JP2003524624A (ja) 治療薬の組織への送達を高める方法及び組成物
Wang et al. Optimization of landscape phage fusion protein-modified polymeric PEG-PE micelles for improved breast cancer cell targeting
JP2023500602A (ja) ペプチド－ナノ粒子コンジュゲート 〔関連出願の相互参照〕 本出願は、２０１９年１０月２９日に出願されたｐｃｔ／ｕｓ２０１９／０５８４６３の一部継続出願であり、２０１９年１０月２９日に出願された米国仮出願第６２／９２７，２９３号の優先権を主張し、その全体が参照により本明細書に組み込まれる。
HK1190632A (en) Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
Yi et al. Mitochondria-Targeting-Based of Paclitaxel-Loaded Triphenylphosphine-Pluronic F127-Hyaluronic Acid Nanomicelles in Multi-Drug Resistant Hepatocellular Carcinoma
Wei et al. Therapeutic effect of hepatocellular carcinoma-targeting liposome delivery system loaded with c [RGDyk] modified combretastatin A-4 and adriamycin: a pharmacodynamics study
Duskey The development and biological evaluation of octreotide containing peptides for receptor mediated non-viral gene delivery
CN109415424A (zh) 肽及其纳米颗粒制剂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1190632

Country of ref document: HK

C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Brinch Jon Christian

Inventor after: CARNES ERIC C

Inventor after: ASHLEY CARLEE ERIN

Inventor after: C - L - Weierman

Inventor before: Brinch Jon Christian

Inventor before: CARNES ERIC C

Inventor before: ASHLEY CARLEE ERIN

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: JEFFREY C. BRINKER ERIC C. CARNES ASHLEY CARLEE ERIN TO: JEFFREY C. BRINKER ERIC C. CARNES ASHLEY CARLEE ERIN CHERYL L. WILLMAN

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140326

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1190632

Country of ref document: HK