CN103649094B - 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 - Google Patents

晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 Download PDF

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CN103649094B
CN103649094B CN201280032432.XA CN201280032432A CN103649094B CN 103649094 B CN103649094 B CN 103649094B CN 201280032432 A CN201280032432 A CN 201280032432A CN 103649094 B CN103649094 B CN 103649094B
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dimethyl
fluoro
spiro
dihydro
phenyl
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CN103649094A (zh
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M.格鲁斯
S.克卢格
S.普吕斯
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Parker Therapeutics
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Gruenenthal GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CN201280032432.XA 2011-07-08 2012-07-06 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺 Active CN103649094B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710173425.6A CN106939005A (zh) 2011-07-08 2012-07-06 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
EP11005587.8 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710173425.6A Division CN106939005A (zh) 2011-07-08 2012-07-06 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Publications (2)

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CN103649094A CN103649094A (zh) 2014-03-19
CN103649094B true CN103649094B (zh) 2017-05-24

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CN201280032432.XA Active CN103649094B (zh) 2011-07-08 2012-07-06 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺
CN201710173425.6A Pending CN106939005A (zh) 2011-07-08 2012-07-06 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

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CN201710173425.6A Pending CN106939005A (zh) 2011-07-08 2012-07-06 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Country Status (23)

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US (2) US8618156B2 (https=)
EP (2) EP3235821B1 (https=)
JP (2) JP6276689B2 (https=)
CN (2) CN103649094B (https=)
AR (1) AR087081A1 (https=)
AU (2) AU2012283449B2 (https=)
BR (1) BR112014000358A2 (https=)
CA (1) CA2841032C (https=)
CY (1) CY1120525T1 (https=)
DK (2) DK2729470T3 (https=)
EA (1) EA026750B1 (https=)
ES (1) ES2641299T3 (https=)
HR (1) HRP20170968T1 (https=)
HU (1) HUE033043T2 (https=)
IL (1) IL230331B (https=)
LT (1) LT2729470T (https=)
MX (1) MX2014000297A (https=)
PL (1) PL2729470T3 (https=)
PT (1) PT2729470T (https=)
RS (1) RS56343B1 (https=)
SI (1) SI2729470T1 (https=)
TW (1) TWI585092B (https=)
WO (1) WO2013007361A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103649094B (zh) * 2011-07-08 2017-05-24 格吕伦塔尔有限公司 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール
EP3253374B1 (en) 2015-02-02 2018-11-28 ratiopharm GmbH Composition comprising cebranopadol in a dissolved form
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定
CN112313202A (zh) * 2019-05-21 2021-02-02 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
EP4665333A1 (en) 2023-02-15 2025-12-24 Adneuris Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1735619A (zh) * 2002-11-11 2006-02-15 格吕伦塔尔有限公司 螺环环己烷衍生物
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit
CN101516844A (zh) * 2006-07-18 2009-08-26 格吕伦塔尔有限公司 具有对阿片样受体体系的活性的4-杂芳基取代的1-氨基环己烷-1-和环己烯-1-衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
KR20130097173A (ko) * 2010-08-04 2013-09-02 그뤼넨탈 게엠베하 신경병증성 통증을 치료하기 위한 ６’­플루오로­（Ｎ­메틸­ 또는 Ｎ，Ｎ­디메틸­）­４­페닐­４’，９’­디하이드로­３’Ｈ­스피로[사이클로헥산­１，１’­피라노[３，４，ｂ]인돌]­４­아민을 포함하는 약제학적 투여형
CN103649094B (zh) * 2011-07-08 2017-05-24 格吕伦塔尔有限公司 晶态的(1r,4r)‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1735619A (zh) * 2002-11-11 2006-02-15 格吕伦塔尔有限公司 螺环环己烷衍生物
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit
CN101516844A (zh) * 2006-07-18 2009-08-26 格吕伦塔尔有限公司 具有对阿片样受体体系的活性的4-杂芳基取代的1-氨基环己烷-1-和环己烯-1-衍生物

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AR087081A1 (es) 2014-02-12
US20130012563A1 (en) 2013-01-10
CN103649094A (zh) 2014-03-19
EP2729470A1 (en) 2014-05-14
RS56343B1 (sr) 2017-12-29
MX2014000297A (es) 2014-01-31
DK2729470T3 (en) 2017-09-11
AU2012283449A1 (en) 2014-02-20
AU2012283449B2 (en) 2017-04-06
WO2013007361A8 (en) 2013-04-04
CA2841032C (en) 2020-12-15
EA201400120A1 (ru) 2014-06-30
SI2729470T1 (sl) 2017-10-30
BR112014000358A2 (pt) 2017-01-10
PT2729470T (pt) 2017-10-02
CY1120525T1 (el) 2019-07-10
EP3235821A1 (en) 2017-10-25
AU2017204572B2 (en) 2018-05-24
TW201311694A (zh) 2013-03-16
JP2017081981A (ja) 2017-05-18
LT2729470T (lt) 2017-08-25
DK3235821T3 (da) 2020-04-20
EA026750B1 (ru) 2017-05-31
JP6559165B2 (ja) 2019-08-14
CA2841032A1 (en) 2013-01-17
WO2013007361A9 (en) 2013-12-27
JP6276689B2 (ja) 2018-02-07
IL230331B (en) 2018-11-29
HUE033043T2 (hu) 2017-11-28
HRP20170968T1 (hr) 2017-09-22
US20130231381A1 (en) 2013-09-05
US8765800B2 (en) 2014-07-01
EP2729470B1 (en) 2017-06-21
US8618156B2 (en) 2013-12-31
AU2012283449A8 (en) 2014-03-27
AU2017204572A1 (en) 2017-07-27
TWI585092B (zh) 2017-06-01
ES2641299T3 (es) 2017-11-08
PL2729470T3 (pl) 2017-11-30
JP2014518226A (ja) 2014-07-28
WO2013007361A1 (en) 2013-01-17
CN106939005A (zh) 2017-07-11
EP3235821B1 (en) 2020-04-08

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