RS56343B1 - Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin - Google Patents

Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin

Info

Publication number
RS56343B1
RS56343B1 RS20170921A RSP20170921A RS56343B1 RS 56343 B1 RS56343 B1 RS 56343B1 RS 20170921 A RS20170921 A RS 20170921A RS P20170921 A RSP20170921 A RS P20170921A RS 56343 B1 RS56343 B1 RS 56343B1
Authority
RS
Serbia
Prior art keywords
crystalline form
dimethyl
fluoro
pyrano
spiro
Prior art date
Application number
RS20170921A
Other languages
English (en)
Serbian (sr)
Inventor
Michael Gruss
Stefan Kluge
Stefan Prühs
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of RS56343B1 publication Critical patent/RS56343B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
RS20170921A 2011-07-08 2012-07-06 Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin RS56343B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
EP12748646.2A EP2729470B1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
RS56343B1 true RS56343B1 (sr) 2017-12-29

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20170921A RS56343B1 (sr) 2011-07-08 2012-07-06 Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin

Country Status (23)

Country Link
US (2) US8618156B2 (https=)
EP (2) EP3235821B1 (https=)
JP (2) JP6276689B2 (https=)
CN (2) CN106939005A (https=)
AR (1) AR087081A1 (https=)
AU (2) AU2012283449B2 (https=)
BR (1) BR112014000358A2 (https=)
CA (1) CA2841032C (https=)
CY (1) CY1120525T1 (https=)
DK (2) DK2729470T3 (https=)
EA (1) EA026750B1 (https=)
ES (1) ES2641299T3 (https=)
HR (1) HRP20170968T1 (https=)
HU (1) HUE033043T2 (https=)
IL (1) IL230331B (https=)
LT (1) LT2729470T (https=)
MX (1) MX2014000297A (https=)
PL (1) PL2729470T3 (https=)
PT (1) PT2729470T (https=)
RS (1) RS56343B1 (https=)
SI (1) SI2729470T1 (https=)
TW (1) TWI585092B (https=)
WO (1) WO2013007361A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106939005A (zh) * 2011-07-08 2017-07-11 格吕伦塔尔有限公司 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺
CA2974578C (en) 2015-01-23 2020-11-17 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
ES2713960T3 (es) 2015-02-02 2019-05-24 Ratiopharm Gmbh Composición que comprende cebranopadol en forma disuelta
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定
WO2020233588A1 (zh) * 2019-05-21 2020-11-26 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
JP2026506102A (ja) 2023-02-15 2026-02-20 アドニューリス・セラピューティクス・インコーポレーテッド 疼痛緩和に有用なレジメンおよび組成物
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
PE20131096A1 (es) * 2010-08-04 2013-10-10 Gruenenthal Chemie Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico
CN106939005A (zh) * 2011-07-08 2017-07-11 格吕伦塔尔有限公司 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Also Published As

Publication number Publication date
WO2013007361A8 (en) 2013-04-04
HUE033043T2 (hu) 2017-11-28
WO2013007361A9 (en) 2013-12-27
EP3235821A1 (en) 2017-10-25
AU2017204572B2 (en) 2018-05-24
JP2017081981A (ja) 2017-05-18
JP6559165B2 (ja) 2019-08-14
AU2017204572A1 (en) 2017-07-27
AU2012283449A8 (en) 2014-03-27
AU2012283449B2 (en) 2017-04-06
JP2014518226A (ja) 2014-07-28
CN103649094B (zh) 2017-05-24
MX2014000297A (es) 2014-01-31
EA026750B1 (ru) 2017-05-31
CN106939005A (zh) 2017-07-11
DK3235821T3 (da) 2020-04-20
CY1120525T1 (el) 2019-07-10
PL2729470T3 (pl) 2017-11-30
WO2013007361A1 (en) 2013-01-17
LT2729470T (lt) 2017-08-25
US20130012563A1 (en) 2013-01-10
PT2729470T (pt) 2017-10-02
US8618156B2 (en) 2013-12-31
ES2641299T3 (es) 2017-11-08
CN103649094A (zh) 2014-03-19
AU2012283449A1 (en) 2014-02-20
EP2729470B1 (en) 2017-06-21
AR087081A1 (es) 2014-02-12
TW201311694A (zh) 2013-03-16
US20130231381A1 (en) 2013-09-05
JP6276689B2 (ja) 2018-02-07
HRP20170968T1 (hr) 2017-09-22
EP3235821B1 (en) 2020-04-08
BR112014000358A2 (pt) 2017-01-10
EP2729470A1 (en) 2014-05-14
CA2841032A1 (en) 2013-01-17
SI2729470T1 (sl) 2017-10-30
CA2841032C (en) 2020-12-15
EA201400120A1 (ru) 2014-06-30
TWI585092B (zh) 2017-06-01
IL230331B (en) 2018-11-29
DK2729470T3 (en) 2017-09-11
US8765800B2 (en) 2014-07-01

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RS56343B1 (sr) Kristalni (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin
AU2012350762B2 (en) Solid forms of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine hydrochloride
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