CN103608039A - 基于bcma的针对多发性骨髓瘤患者的分层与治疗 - Google Patents

基于bcma的针对多发性骨髓瘤患者的分层与治疗 Download PDF

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CN103608039A
CN103608039A CN201280029972.2A CN201280029972A CN103608039A CN 103608039 A CN103608039 A CN 103608039A CN 201280029972 A CN201280029972 A CN 201280029972A CN 103608039 A CN103608039 A CN 103608039A
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bcma
cell
cells
antibody
patient
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E.伯格斯
J.B.赫比斯
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Boehringer Ingelheim International GmbH
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201280029972.2A 2011-04-21 2012-04-20 基于bcma的针对多发性骨髓瘤患者的分层与治疗 Pending CN103608039A (zh)

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EP11163558 2011-04-21
EP11163558.7 2011-04-21
PCT/EP2012/057248 WO2012143498A1 (en) 2011-04-21 2012-04-20 Bcma-based stratification and therapy for multiple myeloma patients

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US (3) US20130101599A1 (https=)
EP (1) EP2699259B1 (https=)
JP (1) JP2014520248A (https=)
KR (1) KR20140031905A (https=)
CN (1) CN103608039A (https=)
AP (1) AP2013007178A0 (https=)
AU (1) AU2012244676A1 (https=)
CA (1) CA2832510A1 (https=)
CL (1) CL2013003031A1 (https=)
CO (1) CO6801644A2 (https=)
EA (1) EA201301180A1 (https=)
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MX (1) MX2013012167A (https=)
PE (1) PE20140612A1 (https=)
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Cited By (7)

* Cited by examiner, † Cited by third party
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CN110167964A (zh) * 2016-11-02 2019-08-23 英格玛布有限责任公司 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物
CN110431151A (zh) * 2016-12-21 2019-11-08 特尼奥生物股份有限公司 仅有重链的抗bcma抗体
CN110891971A (zh) * 2017-06-20 2020-03-17 特尼奥生物股份有限公司 仅有重链的抗bcma抗体
CN111094353A (zh) * 2017-09-14 2020-05-01 葛兰素史密斯克莱知识产权发展有限公司 用于癌症的组合治疗
CN112698037A (zh) * 2021-03-25 2021-04-23 北京积水潭医院 一种检测多发性骨髓瘤治疗效果的抗体组合物及其试剂盒和应用
CN112955748A (zh) * 2018-10-31 2021-06-11 葛兰素史密斯克莱知识产权发展有限公司 治疗癌症的方法
CN114773476A (zh) * 2015-04-13 2022-07-22 辉瑞公司 治疗性抗体和它们的用途

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BR112016018100A2 (pt) 2014-02-07 2018-02-20 Univ Mcmaster acoplador antigênico de células t trifuncional, métodos e usos do mesmo
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US20160131655A1 (en) 2016-05-12

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