CN103570727B - 一种n-苄基色胺酮衍生物及其制备方法和应用 - Google Patents

一种n-苄基色胺酮衍生物及其制备方法和应用 Download PDF

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Publication number
CN103570727B
CN103570727B CN201310560572.0A CN201310560572A CN103570727B CN 103570727 B CN103570727 B CN 103570727B CN 201310560572 A CN201310560572 A CN 201310560572A CN 103570727 B CN103570727 B CN 103570727B
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methyltryptamine
ketone
derivative
benzyl
couroupitine
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CN103570727A (zh
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杨青
匡春香
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Fudan University
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Fudan University
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Priority to CN201310560572.0A priority Critical patent/CN103570727B/zh
Publication of CN103570727A publication Critical patent/CN103570727A/zh
Priority to CA2930203A priority patent/CA2930203A1/en
Priority to KR1020167015465A priority patent/KR20160103986A/ko
Priority to AU2014350729A priority patent/AU2014350729B2/en
Priority to EA201690915A priority patent/EA201690915A1/ru
Priority to CN201480067750.9A priority patent/CN105829312B/zh
Priority to PCT/CN2014/090947 priority patent/WO2015070766A1/zh
Priority to MX2016006217A priority patent/MX2016006217A/es
Priority to EP14861381.3A priority patent/EP3070089B1/en
Priority to US15/036,384 priority patent/US10059712B2/en
Priority to JP2016552662A priority patent/JP6629218B2/ja
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Publication of CN103570727B publication Critical patent/CN103570727B/zh
Priority to ZA2016/03889A priority patent/ZA201603889B/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Biomedical Technology (AREA)
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  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
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  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201310560572.0A 2013-11-12 2013-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用 Active CN103570727B (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201310560572.0A CN103570727B (zh) 2013-11-12 2013-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用
PCT/CN2014/090947 WO2015070766A1 (zh) 2013-11-12 2014-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用
EP14861381.3A EP3070089B1 (en) 2013-11-12 2014-11-12 Aminomethyl tryptanthrin derivative, preparation method and application thereof
AU2014350729A AU2014350729B2 (en) 2013-11-12 2014-11-12 N-benzyl tryptanthrin derivative, and preparation method and application thereof
EA201690915A EA201690915A1 (ru) 2013-11-12 2014-11-12 Производное n-бензилтриптантрина, а также способ его получения и применение
CN201480067750.9A CN105829312B (zh) 2013-11-12 2014-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用
CA2930203A CA2930203A1 (en) 2013-11-12 2014-11-12 N-benzyl tryptanthrin derivative, and preparation method and application thereof
MX2016006217A MX2016006217A (es) 2013-11-12 2014-11-12 Derivados de n-bencil triptantrina y metodo de preparacion y aplicacion de los mismos.
KR1020167015465A KR20160103986A (ko) 2013-11-12 2014-11-12 N-벤질 트립탄트린 유도체, 및 이의 제조 방법 및 적용
US15/036,384 US10059712B2 (en) 2013-11-12 2014-11-12 N-benzyl tryptanthrin derivative, and preparation method and application thereof
JP2016552662A JP6629218B2 (ja) 2013-11-12 2014-11-12 Ｎ−ベンジルトリプタンスリン誘導体、ならびにその調製方法および利用
ZA2016/03889A ZA201603889B (en) 2013-11-12 2016-06-08 N-benzyl tryptanthrin derivative, and preparation method and application thereof

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Application Number Priority Date Filing Date Title
CN201310560572.0A CN103570727B (zh) 2013-11-12 2013-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用

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CN103570727A CN103570727A (zh) 2014-02-12
CN103570727B true CN103570727B (zh) 2015-08-19

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CN201310560572.0A Active CN103570727B (zh) 2013-11-12 2013-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用
CN201480067750.9A Active CN105829312B (zh) 2013-11-12 2014-11-12 一种n-苄基色胺酮衍生物及其制备方法和应用

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US (1) US10059712B2 (enExample)
EP (1) EP3070089B1 (enExample)
JP (1) JP6629218B2 (enExample)
KR (1) KR20160103986A (enExample)
CN (2) CN103570727B (enExample)
AU (1) AU2014350729B2 (enExample)
CA (1) CA2930203A1 (enExample)
EA (1) EA201690915A1 (enExample)
MX (1) MX2016006217A (enExample)
WO (1) WO2015070766A1 (enExample)
ZA (1) ZA201603889B (enExample)

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CN103570726B (zh) * 2013-07-15 2016-04-06 上海天慈生物谷生物工程有限公司 N-烷基色胺酮衍生物及其制备方法和应用
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CN104844607B (zh) * 2015-03-26 2018-02-16 玉林师范学院 一种具有抗肿瘤活性的色胺酮溴代衍生物及其合成方法
CN105218476B (zh) * 2015-10-29 2018-03-13 上海天慈生物谷生物工程有限公司 一种治疗肺癌药物的制备方法
CN105330666B (zh) * 2015-11-27 2018-10-30 西北大学 色胺酮衍生物、合成方法及其药用用途
CN106928230B (zh) * 2015-12-30 2021-03-19 苏州如鹰生物医药有限公司 N-芳基、苄基色胺酮及其衍生物在制备hIDO2抑制剂中的用途
CN106928229B (zh) * 2015-12-30 2021-03-19 苏州如鹰生物医药有限公司 色胺酮及其衍生物在制备hIDO2抑制剂中的用途
CN107141292B (zh) * 2016-03-01 2019-02-12 华中师范大学 一种色胺酮类化合物的制备方法
US10669273B2 (en) * 2016-04-05 2020-06-02 Peking University Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
WO2018136437A2 (en) 2017-01-17 2018-07-26 Tesaro, Inc. Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
US11103511B2 (en) 2017-06-05 2021-08-31 Fudan University Substituted indolo[2,1-b]quinazolines as inhibitors of tryptophan dioxygenase and indoleamine 2,3-dioxygenase 1
CN107286165B (zh) * 2017-06-09 2019-07-26 扬州大学 合成色胺酮类化合物的方法
JP7306634B2 (ja) 2017-10-19 2023-07-11 一般社団法人ファルマバレープロジェクト支援機構 Ｉｄｏ／ｔｄｏ阻害剤
EP3823604A4 (en) 2018-07-17 2022-03-16 Board of Regents, The University of Texas System COMPOUNDS AS INHIBITORS OF INDOLAMINE-2,3-DIOXYGENASE AND/OR TRYPTOPHANE DIOXYGENASE
CN110734423B (zh) * 2018-07-18 2022-07-08 复旦大学 一类吲哚醌类吲哚胺-2,3-双加氧酶抑制剂及其药用用途
CN111135178A (zh) * 2018-11-02 2020-05-12 苏州如鹰生物医药有限公司 色胺酮衍生物治疗神经系统疾病的用途
CN110041335B (zh) * 2019-04-24 2022-01-07 同济大学 一种提高色胺酮的水溶性的方法、色胺酮衍生物及其制备方法和应用
CN110183454B (zh) * 2019-06-20 2022-01-07 同济大学 一种含1,2,3-三氮唑的色胺酮及其制备方法和应用
CN110294740A (zh) * 2019-06-20 2019-10-01 同济大学 一种n-苄基氨基酸水溶性色胺酮及其制备方法和应用
CN110283192B (zh) * 2019-07-18 2021-08-06 同济大学 一种含硼酸的色胺酮衍生物的制备方法及应用
CN110903449B (zh) * 2019-12-02 2022-09-06 大连理工大学 一种靛红芳烃共聚物、制备方法及应用
CN112724147B (zh) * 2020-12-23 2022-03-15 合肥工业大学 4(3h)-喹唑啉酮类化合物的制备方法
CN112641728A (zh) * 2020-12-27 2021-04-13 陕西中医药大学 一种色胺酮纳米脂质体及其制备方法
CN118766924A (zh) * 2024-07-08 2024-10-15 陕西中医药大学 一种色胺酮在制备抗结肠癌药物中的应用

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MX2016006217A (es) 2017-02-23
AU2014350729A1 (en) 2016-06-16
AU2014350729B2 (en) 2019-01-03
US20160297822A1 (en) 2016-10-13
CN105829312B (zh) 2018-09-28
WO2015070766A1 (zh) 2015-05-21
EP3070089A1 (en) 2016-09-21
EP3070089A4 (en) 2017-04-26
US10059712B2 (en) 2018-08-28
CN105829312A (zh) 2016-08-03
JP2016535788A (ja) 2016-11-17
EA201690915A1 (ru) 2017-02-28
JP6629218B2 (ja) 2020-01-15
KR20160103986A (ko) 2016-09-02
CN103570727A (zh) 2014-02-12
CA2930203A1 (en) 2015-05-21
ZA201603889B (en) 2019-09-25
EP3070089B1 (en) 2019-10-16

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