CN103502246A - 异噁唑衍生物 - Google Patents

异噁唑衍生物 Download PDF

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Publication number
CN103502246A
CN103502246A CN201280012748.2A CN201280012748A CN103502246A CN 103502246 A CN103502246 A CN 103502246A CN 201280012748 A CN201280012748 A CN 201280012748A CN 103502246 A CN103502246 A CN 103502246A
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CN
China
Prior art keywords
alkyl
methyl
haloalkyl
compound
halogenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280012748.2A
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English (en)
Chinese (zh)
Inventor
N·高维里
S·南申
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Tiergesundheit AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN103502246A publication Critical patent/CN103502246A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201280012748.2A 2011-03-10 2012-03-09 异噁唑衍生物 Pending CN103502246A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH00407/11 2011-03-10
CH4072011 2011-03-10
PCT/EP2012/054161 WO2012120135A1 (en) 2011-03-10 2012-03-09 Isoxazole derivatives

Publications (1)

Publication Number Publication Date
CN103502246A true CN103502246A (zh) 2014-01-08

Family

ID=45809012

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280012748.2A Pending CN103502246A (zh) 2011-03-10 2012-03-09 异噁唑衍生物

Country Status (15)

Country Link
US (1) US8822466B2 (enExample)
EP (1) EP2683713B1 (enExample)
JP (1) JP2014507459A (enExample)
CN (1) CN103502246A (enExample)
AR (1) AR085657A1 (enExample)
AU (1) AU2012224521B2 (enExample)
BR (1) BR112013022755A2 (enExample)
CA (1) CA2829149A1 (enExample)
CL (1) CL2013002472A1 (enExample)
CO (1) CO6801794A2 (enExample)
ES (1) ES2542409T3 (enExample)
MX (1) MX2013010297A (enExample)
RU (1) RU2013145304A (enExample)
WO (1) WO2012120135A1 (enExample)
ZA (1) ZA201306175B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795093A (zh) * 2014-10-14 2017-05-31 先正达参股股份有限公司 用于制备1‑(3,5‑二氯苯基)‑2,2,2‑三氟乙酮及其衍生物的方法
CN106795082A (zh) * 2014-10-14 2017-05-31 先正达参股股份有限公司 用于制备1‑(3,5‑二氯‑4‑氟‑苯基)‑2,2,2‑三氟‑乙酮的方法
CN107074835A (zh) * 2014-11-10 2017-08-18 瑞士诺华动物保健有限公司 二芳基异噁唑啉化合物
CN109068651A (zh) * 2016-02-24 2018-12-21 梅里亚股份有限公司 抗寄生物的异噁唑啉化合物、包含它们的长效可注射制剂、其方法和用途
TWI670255B (zh) * 2014-10-14 2019-09-01 瑞士商先正達合夥公司 用於製備鹵代苯之方法

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UY33403A (es) * 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
HUE043949T2 (hu) 2012-02-06 2019-09-30 Boehringer Ingelheim Animal Health Usa Inc Szisztémásan ható hatóanyagokat tartalmazó, parazitaellenes, szájon át adagolt állatgyógyászati készítmények, eljárások és alkalmazásuk
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
KR102191469B1 (ko) 2013-02-06 2020-12-16 바이엘 애니멀 헬스 게엠베하 해충 방제제로서의 할로겐-치환된 피라졸 유도체
CA2916833A1 (en) 2013-06-24 2014-12-31 Basf Se Thiophene- or furan-substituted isothiazoline compounds as pesticides
US9944597B2 (en) 2013-09-16 2018-04-17 The Board Of Regents Of The University Of Texas System Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
US9447084B2 (en) 2013-11-01 2016-09-20 Merial, Inc. Antiparisitic and pesticidal isoxazoline compounds
EP3089972B1 (de) 2014-01-03 2018-05-16 Bayer Animal Health GmbH Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel
CN106455560B (zh) 2014-04-17 2020-12-22 勃林格殷格翰动物保健美国公司 用于保护动物免受寄生物的丙二腈化合物的用途
WO2016008830A1 (de) 2014-07-15 2016-01-21 Bayer Cropscience Aktiengesellschaft Aryl-triazolyl-pyridine als schädlingsbekämpfungsmittel
JP6640209B2 (ja) 2014-10-14 2020-02-05 シンジェンタ パーティシペーションズ アーゲー ５−ブロモ−１，２，３−トリクロロベンゼンを調製するプロセス
PY1609250A (es) 2015-02-26 2018-03-01 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG11201708068PA (en) 2015-04-08 2017-10-30 Merial Inc Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
CN114891070A (zh) 2015-05-20 2022-08-12 勃林格殷格翰动物保健美国公司 驱虫缩酚酸肽化合物
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
EP3525590B1 (en) 2016-10-14 2025-08-20 Boehringer Ingelheim Vetmedica GmbH Pesticidal and parasiticidal vinyl isoxazoline compounds
MX2019005628A (es) 2016-11-16 2019-12-18 Boehringer Ingelheim Animal Health Usa Inc Compuestos depsipeptidos antihelminticos.
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
ES2944616T3 (es) 2017-08-14 2023-06-22 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
US11773066B2 (en) 2018-11-20 2023-10-03 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
BR112021018631A2 (pt) 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
AR119790A1 (es) 2019-08-29 2022-01-12 Pi Industries Ltd Compuestos de isoxazolina y su uso como agentes para el control de plagas
US11091447B2 (en) 2020-01-03 2021-08-17 Berg Llc UBE2K modulators and methods for their use
WO2021242481A1 (en) 2020-05-28 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
JP7824305B2 (ja) 2021-01-27 2026-03-04 コルテバ アグリサイエンス エルエルシー 魚における寄生生物に対するシクロプロピルアミド化合物
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
WO2025257633A1 (en) 2024-06-12 2025-12-18 Boehringer Ingelheim Vetmedica Gmbh Long-acting castor oil-containing injectable formulations and methods of use thereof
WO2026024600A1 (en) 2024-07-22 2026-01-29 Zoetis Services Llc Isoxazoline and macrocyclic lactone microspheres
WO2026043852A1 (en) 2024-08-20 2026-02-26 Zoetis Services Llc Process for preparing optically enriched isoxazolines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079162A1 (en) * 2005-12-30 2007-07-12 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
CN101331127A (zh) * 2005-12-16 2008-12-24 杜邦公司 用于防治无脊椎害虫的5-芳基异噁唑啉
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds
WO2011157748A1 (en) * 2010-06-17 2011-12-22 Novartis Ag 5-aryl isoxazolines for controlling pests

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
BRPI0707091B8 (pt) * 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
KR20090130064A (ko) * 2007-04-10 2009-12-17 바이엘 크롭사이언스 아게 살충성 아릴 이속사졸린 유도체
TWI649303B (zh) 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
WO2009071500A2 (en) 2007-12-03 2009-06-11 Novartis Ag Organic compounds
JP2010235590A (ja) * 2009-03-09 2010-10-21 Nissan Chem Ind Ltd 置換イソキサゾリン化合物及び有害生物防除剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101331127A (zh) * 2005-12-16 2008-12-24 杜邦公司 用于防治无脊椎害虫的5-芳基异噁唑啉
WO2007079162A1 (en) * 2005-12-30 2007-07-12 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds
WO2011157748A1 (en) * 2010-06-17 2011-12-22 Novartis Ag 5-aryl isoxazolines for controlling pests

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795093A (zh) * 2014-10-14 2017-05-31 先正达参股股份有限公司 用于制备1‑(3,5‑二氯苯基)‑2,2,2‑三氟乙酮及其衍生物的方法
CN106795082A (zh) * 2014-10-14 2017-05-31 先正达参股股份有限公司 用于制备1‑(3,5‑二氯‑4‑氟‑苯基)‑2,2,2‑三氟‑乙酮的方法
CN106795093B (zh) * 2014-10-14 2019-05-28 先正达参股股份有限公司 用于制备1-(3,5-二氯苯基)-2,2,2-三氟乙酮及其衍生物的方法
TWI670255B (zh) * 2014-10-14 2019-09-01 瑞士商先正達合夥公司 用於製備鹵代苯之方法
CN117550960A (zh) * 2014-10-14 2024-02-13 先正达参股股份有限公司 用于制备1-(3,5-二氯-4-氟-苯基)-2,2,2-三氟-乙酮的方法
CN107074835A (zh) * 2014-11-10 2017-08-18 瑞士诺华动物保健有限公司 二芳基异噁唑啉化合物
CN107074835B (zh) * 2014-11-10 2020-05-19 瑞士伊兰科动物保健有限公司 二芳基异噁唑啉化合物
CN109068651A (zh) * 2016-02-24 2018-12-21 梅里亚股份有限公司 抗寄生物的异噁唑啉化合物、包含它们的长效可注射制剂、其方法和用途

Also Published As

Publication number Publication date
NZ614662A (en) 2015-06-26
BR112013022755A2 (pt) 2019-09-24
MX2013010297A (es) 2013-10-17
EP2683713A1 (en) 2014-01-15
EP2683713B1 (en) 2015-04-22
JP2014507459A (ja) 2014-03-27
CL2013002472A1 (es) 2014-03-07
CO6801794A2 (es) 2013-11-29
US8822466B2 (en) 2014-09-02
US20130345221A1 (en) 2013-12-26
AU2012224521B2 (en) 2015-10-29
CA2829149A1 (en) 2012-09-13
RU2013145304A (ru) 2015-04-20
ES2542409T3 (es) 2015-08-05
WO2012120135A1 (en) 2012-09-13
ZA201306175B (en) 2014-04-30
AR085657A1 (es) 2013-10-16
AU2012224521A1 (en) 2013-09-05

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: SWISS NOVARTIS ANIMAL HEALTH CO., LTD.

Free format text: FORMER OWNER: NOVARTIS AG

Effective date: 20150423

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20150423

Address after: Basel

Applicant after: Animal health company limited of Novartis of Switzerland

Address before: Basel

Applicant before: Novartis AG

AD01 Patent right deemed abandoned

Effective date of abandoning: 20161102

C20 Patent right or utility model deemed to be abandoned or is abandoned