CN103442693A - L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用 - Google Patents

L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用 Download PDF

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Publication number
CN103442693A
CN103442693A CN2011800648945A CN201180064894A CN103442693A CN 103442693 A CN103442693 A CN 103442693A CN 2011800648945 A CN2011800648945 A CN 2011800648945A CN 201180064894 A CN201180064894 A CN 201180064894A CN 103442693 A CN103442693 A CN 103442693A
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pharmaceutically acceptable
levodopa
weight
carbidopa
arginine
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CN2011800648945A
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Chinese (zh)
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奥伦·亚柯比-泽维
玛拉·尼玛斯
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Neuroderm Ltd
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Neuroderm Ltd
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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CN2011800648945A 2010-11-15 2011-11-15 L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用 Pending CN103442693A (zh)

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CN201910369050.XA CN110123743A (zh) 2010-11-15 2011-11-15 L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用

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US41363710P 2010-11-15 2010-11-15
US61/413,637 2010-11-15
US201161524064P 2011-08-16 2011-08-16
US61/524,064 2011-08-16
PCT/IL2011/000881 WO2012066538A1 (en) 2010-11-15 2011-11-15 Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same

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CN201910369050.XA Pending CN110123743A (zh) 2010-11-15 2011-11-15 L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用

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CN106413754A (zh) * 2014-03-13 2017-02-15 纽罗德姆有限公司 多巴脱羧酶抑制剂组合物
CN106619490A (zh) * 2017-01-19 2017-05-10 云南白药集团无锡药业有限公司 一种左旋多巴透皮贴剂及其制备方法
CN111701024A (zh) * 2020-05-26 2020-09-25 上海京新生物医药有限公司 一种左旋多巴制剂及其制备方法及其应用

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WO2014141261A1 (en) * 2013-03-13 2014-09-18 Neuroderm Ltd Method for treatment of parkinson's disease
JP6528281B2 (ja) * 2014-01-29 2019-06-12 国立研究開発法人産業技術総合研究所 シクロデキストリンの利用による抗がん活性が増強されたアシュワガンダ葉の水抽出物の調製方法、及びアシュワガンダ葉を含む医薬組成物
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EP3188725B1 (en) 2014-09-04 2020-10-28 Lobsor Pharmaceuticals Aktiebolag Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof
MX381069B (es) 2014-10-21 2025-03-12 Abbvie Inc Profármacos de carbidopa y l-dopa y métodos de uso.
MA41377A (fr) * 2015-01-20 2017-11-28 Abbvie Inc Gel intestinal de lévodopa et de carbidona et procédés d'utilisation
CA3019382A1 (en) 2015-03-30 2016-10-06 Berlirem Gmbh Water-soluble l-dopa esters
EP3075723B1 (en) 2015-03-30 2017-05-24 Berlirem GmbH Highly soluble l-dopa glycerol esters
EP3291872A4 (en) 2015-05-06 2019-02-13 SynAgile Corporation PHARMACEUTICAL SUSPENSIONS WITH ACTIVE SUBSTANCES, DEVICES FOR THEIR ADMINISTRATION AND METHOD FOR THEIR USE
WO2017039525A1 (en) * 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
EP4295909A3 (en) * 2016-04-20 2024-07-17 AbbVie Inc. Carbidopa and l-dopa prodrugs and methods of use
EP3275433A1 (en) * 2016-07-29 2018-01-31 Som Innovation Biotech S.L. Sustained release composition comprising micronized tolcapone
AU2018280745B2 (en) 2017-06-05 2023-03-09 Dizlin Pharmaceuticals Ab Levodopa infusion solution
CN113274578B (zh) 2017-07-07 2022-06-03 纽罗德姆有限公司 用于流体药物的皮下输送的设备
KR20250043584A (ko) 2018-03-23 2025-03-28 롭서 파마슈티컬스 악티에볼라그 신경퇴행성 장애의 치료를 위한 약제학적 조성물의 연속 투여
SG11202104499RA (en) 2018-11-15 2021-05-28 Abbvie Inc Pharmaceutical formulations for subcutaneous administration
CN111643493B (zh) * 2020-05-26 2023-01-10 上海京新生物医药有限公司 一种高浓度左旋多巴制剂及其制备方法及其应用
WO2022047298A1 (en) * 2020-08-31 2022-03-03 Purdue Pharma L.P. Compositions and methods for levodopa delivery
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
MX2024008375A (es) * 2022-01-03 2024-09-18 Neuroderm Ltd Metodos y composiciones para el tratamiento de la enfermedad de parkinson.
EP4223288B1 (en) 2022-02-07 2024-03-06 Berlirem GmbH Novel kit of pharmaceutical preparations for the treatment of parkinson's disease
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

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