CN103432365A - Pharmaceutical composition for preventing and treating black shell disease of macrobrachium rosenbergii and method for preparing pharmaceutical composition - Google Patents
Pharmaceutical composition for preventing and treating black shell disease of macrobrachium rosenbergii and method for preparing pharmaceutical composition Download PDFInfo
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- CN103432365A CN103432365A CN2013103427663A CN201310342766A CN103432365A CN 103432365 A CN103432365 A CN 103432365A CN 2013103427663 A CN2013103427663 A CN 2013103427663A CN 201310342766 A CN201310342766 A CN 201310342766A CN 103432365 A CN103432365 A CN 103432365A
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating a black shell disease of macrobrachium rosenbergii. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 20-40 parts of rhubarb, 20-30 parts of Chinese gall, 20-35 parts of excoecaria sebifera, 20-30 parts of portulaca oleracea, 20-30 parts of chrysanthemum indicum, 25-35 parts of garlic, 25-35 parts of the root of Chinese pulsatilla and 10-20 parts of coptosapelta diffusa. The invention also discloses a method for preparing the pharmaceutical composition. The pharmaceutical composition is reasonable in formula design, and all the contained drugs are low-toxicity traditional Chinese medicines; moreover, according to the composition, advantages of various medicines are fully utilized, the antibiotic and antibacterial effects are enhanced, the black shell disease of the macrobrachium rosenbergii can be effectively treated, and the cure rate is 100 percent. The provided preparation method is simple, easy to implement, convenient to feed and suitable for large-scale production.
Description
Technical field
The present invention relates to treat the field of Chinese medicines of shrimps disease, be specifically related to a kind of pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases and preparation method thereof.
Background technology
In recent years, middle and late stage in the ripe Luo pond crayfishes cultivation, shrimp body shell blackout phenomenon appears in many pools mouth in succession, pitchy in various degree, the speckle of brownish black appear in the carapace, sternite, swimmeret, the tail fan that are shrimp, serious meeting parcel whole body shell, support the shrimp family and generally be referred to as " black shell diseases ".
" black shell diseases " of Macrobrachium rosenbergii generally occurs in the middle and late stage of cultivation, and the shrimp body case is brownish black, pitchy speckle in various degree, serious meeting parcel whole body shell.Through microscopy, grow nonparasitically upon another plant as seen a large amount of filamentous bacterias are arranged on the swimmeret of shrimp, tail fan, the algae such as the spirulina that has quantity not wait of growing nonparasitically upon another plant on the gill filament, dinoflagellate.The shrimp body of some pool mouth is the Infusorias such as parasitic a fairly large number of vorticella, Zoothamnium, cup worm also.The even visible blue mud tongue of some shrimps pond surrounding and shrimp body grows phenomenon.The one-tenth shrimp performance that obtains " black shell diseases " has loss of appetite, shell difficulty, poor growth phenomenon in various degree.
Treatment about black shell diseases at present also needs collaborative treatment of Chinese and western medicines, but Western medicine obviously has injury to fish itself, and can cause the food safety hidden danger in later stage.
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of pharmaceutical composition for the treatment of the Macrobrachium rosenbergii black shell diseases and preparation method thereof.
Technical scheme: in order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases, the raw material by following parts by weight is prepared from: 20 ~ 40 parts of Radix Et Rhizoma Rhei, 20 ~ 30 parts of Galla Chinensiss, 20 ~ 35 parts of Cortex Sapii Radiciss, 20 ~ 30 parts of Herba Portulacaes, 20 ~ 30 parts, Herba Dendranthematis indici, 25 ~ 35 parts, Bulbus Allii, 25 ~ 35 parts of the Radix Pulsatillaes, 10 ~ 20 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
Raw material by following parts by weight is prepared from: 30 ~ 40 parts of Radix Et Rhizoma Rhei, 25 ~ 30 parts of Galla Chinensiss, 25 ~ 35 parts of Cortex Sapii Radiciss, 25 ~ 30 parts of Herba Portulacaes, 25 ~ 30 parts, Herba Dendranthematis indici, 30 ~ 35 parts, Bulbus Allii, 30 ~ 35 parts of the Radix Pulsatillaes, 15 ~ 20 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
Raw material by following parts by weight is prepared from: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Galla Chinensiss, 25 parts of Cortex Sapii Radiciss, 25 parts of Herba Portulacaes, 25 parts, Herba Dendranthematis indici, 30 parts, Bulbus Allii, 30 parts of the Radix Pulsatillaes, 15 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
The preparation method of the pharmaceutical composition of described treatment Macrobrachium rosenbergii black shell diseases comprises the following steps:
1) take each crude drug by above-mentioned parts by weight, and pulverized 350 mesh sieves with super micron mill, make powder;
2) by adding the water of 20 times of powder weight in the powder after pulverizing, add in the pot that is used as medicine and decoct and within 50 minutes, obtain liquid medicine, flame-out;
While 3) being cooled to 25 ℃, according to the weight ratio of liquid medicine: prawn feed=1:25, prawn feed is immersed in liquid medicine 35 minutes, and mixing and stirring, make the hybrid particles of medicine and feedstuff.
The particle diameter of described hybrid particles is 1.5 ~ 1.8mm.
The feeding method that contains the pharmaceutical composition that above-mentioned raw materials makes provided by the invention is: within 20 ~ 30 days before Macrobrachium rosenbergii black shell diseases morbidity season, aforementioned pharmaceutical compositions is thrown something and fed 30 ~ 40 days continuously, or at the initial stage of a disease aforementioned pharmaceutical compositions is thrown something and fed 40 ~ 50 days continuously.
Beneficial effect: pharmaceutical composition recipe design of the present invention is reasonable, and contained drug is low toxicity Chinese medicine, and said composition takes full advantage of the advantage of each medicine, has strengthened the effect of antibacterial bacteriostatic, can effectively treat Macrobrachium rosenbergii lean type disease, and cure rate reaches 100%.Preparation method provided by the invention is simple, the convenience of throwing something and feeding, and is applicable to large-scale production.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
embodiment 1:
A kind of pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases, the raw material by following parts by weight is prepared from: 20 parts of Radix Et Rhizoma Rhei, 20 parts of Galla Chinensiss, 20 parts of Cortex Sapii Radiciss, 20 parts of Herba Portulacaes, 20 parts, Herba Dendranthematis indici, 25 parts, Bulbus Allii, 25 parts of the Radix Pulsatillaes, 10 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
The preparation method of the pharmaceutical composition of described treatment Macrobrachium rosenbergii black shell diseases comprises the following steps:
1) take each crude drug by above-mentioned parts by weight, and pulverized 350 mesh sieves with super micron mill, make powder;
2) by adding the water of 20 times of powder weight in the powder after pulverizing, add in the pot that is used as medicine and decoct and within 50 minutes, obtain liquid medicine, flame-out;
While 3) being cooled to 25 ℃, according to the weight ratio of liquid medicine: prawn feed=1:25, prawn feed is immersed in liquid medicine 35 minutes, and mixing and stirring, make the hybrid particles of medicine and feedstuff.
The particle diameter of described hybrid particles is 1.5mm.
embodiment 2:
A kind of pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases, the raw material by following parts by weight is prepared from: 40 parts of Radix Et Rhizoma Rhei, 30 parts of Galla Chinensiss, 35 parts of Cortex Sapii Radiciss, 30 parts of Herba Portulacaes, 30 parts, Herba Dendranthematis indici, 35 parts, Bulbus Allii, 35 parts of the Radix Pulsatillaes, 20 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
The preparation method of the pharmaceutical composition of described treatment Macrobrachium rosenbergii black shell diseases comprises the following steps:
1) take each crude drug by above-mentioned parts by weight, and pulverized 350 mesh sieves with super micron mill, make powder;
2) by adding the water of 20 times of powder weight in the powder after pulverizing, add in the pot that is used as medicine and decoct and within 50 minutes, obtain liquid medicine, flame-out;
While 3) being cooled to 25 ℃, according to the weight ratio of liquid medicine: prawn feed=1:25, prawn feed is immersed in liquid medicine 35 minutes, and mixing and stirring, make the hybrid particles of medicine and feedstuff.
The particle diameter of described hybrid particles is 1.8mm.
embodiment 3:
A kind of pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases, the raw material by following parts by weight is prepared from: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Galla Chinensiss, 25 parts of Cortex Sapii Radiciss, 25 parts of Herba Portulacaes, 25 parts, Herba Dendranthematis indici, 30 parts, Bulbus Allii, 30 parts of the Radix Pulsatillaes, 15 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
The preparation method of the pharmaceutical composition of described treatment Macrobrachium rosenbergii black shell diseases comprises the following steps:
1) take each crude drug by above-mentioned parts by weight, and pulverized 350 mesh sieves with super micron mill, make powder;
2) by adding the water of 20 times of powder weight in the powder after pulverizing, add in the pot that is used as medicine and decoct and within 50 minutes, obtain liquid medicine, flame-out;
While 3) being cooled to 25 ℃, according to the weight ratio of liquid medicine: prawn feed=1:25, prawn feed is immersed in liquid medicine 35 minutes, and mixing and stirring, make the hybrid particles of medicine and feedstuff.
The particle diameter of described hybrid particles is 1.6mm.
The embodiment of the present invention 1 ~ 3 any one pharmaceutical composition usage and consumption: within 20 ~ 30 days before Macrobrachium rosenbergii black shell diseases morbidity season, aforementioned pharmaceutical compositions is thrown something and fed 30 ~ 40 days continuously, or at the initial stage of a disease aforementioned pharmaceutical compositions is thrown something and fed 40 ~ 50 days continuously.
Feeding method:
1), prevention: aforementioned pharmaceutical compositions was thrown something and fed 40 days continuously in 20 ~ 30 days before Macrobrachium rosenbergii black shell diseases morbidity season.
2), treatment: cause shrimp death or stop eating when the black shell diseases morbidity appears in the shrimp pool, aforementioned pharmaceutical compositions is thrown something and fed 45 days continuously.
Result of the test: after the prevention phase, prawn death do not occur, prevention rate 100%.30 ~ 90 days later treatment phase, cure rate 100% shrimp death or the phenomenon of stopping eating do not appear.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (5)
1. a pharmaceutical composition of preventing and treating the Macrobrachium rosenbergii black shell diseases, it is characterized in that, the raw material by following parts by weight is prepared from: 20 ~ 40 parts of Radix Et Rhizoma Rhei, 20 ~ 30 parts of Galla Chinensiss, 20 ~ 35 parts of Cortex Sapii Radiciss, 20 ~ 30 parts of Herba Portulacaes, 20 ~ 30 parts, Herba Dendranthematis indici, 25 ~ 35 parts, Bulbus Allii, 25 ~ 35 parts of the Radix Pulsatillaes, 10 ~ 20 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
2. pharmaceutical composition according to claim 1, it is characterized in that, the raw material by following parts by weight is prepared from: 30 ~ 40 parts of Radix Et Rhizoma Rhei, 25 ~ 30 parts of Galla Chinensiss, 25 ~ 35 parts of Cortex Sapii Radiciss, 25 ~ 30 parts of Herba Portulacaes, 25 ~ 30 parts, Herba Dendranthematis indici, 30 ~ 35 parts, Bulbus Allii, 30 ~ 35 parts of the Radix Pulsatillaes, 15 ~ 20 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
3. pharmaceutical composition according to claim 1, it is characterized in that, the raw material by following parts by weight is prepared from: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Galla Chinensiss, 25 parts of Cortex Sapii Radiciss, 25 parts of Herba Portulacaes, 25 parts, Herba Dendranthematis indici, 30 parts, Bulbus Allii, 30 parts of the Radix Pulsatillaes, 15 parts of Coptosapelta diffusa (Champ. Ex Benth) van steenis (Thysanospermum diffusum Champ.ex Benth.)s.
4. the preparation method of the pharmaceutical composition of the described treatment Macrobrachium rosenbergii of claim 1 ~ 3 any one black shell diseases, is characterized in that, comprises the following steps:
1) take each crude drug by above-mentioned parts by weight, and pulverized 350 mesh sieves with super micron mill, make powder;
2) by adding the water of 20 times of powder weight in the powder after pulverizing, add in the pot that is used as medicine and decoct and within 50 minutes, obtain liquid medicine, flame-out;
While 3) being cooled to 25 ℃, according to the weight ratio of liquid medicine: prawn feed=1:25, prawn feed is immersed in liquid medicine 35 minutes, and mixing and stirring, make the hybrid particles of medicine and feedstuff.
5. the preparation method of pharmaceutical composition according to claim 4, is characterized in that, the particle diameter of described hybrid particles is 1.5 ~ 1.8mm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147789A (en) * | 2015-10-23 | 2015-12-16 | 施瑞客（天津）生物技术有限公司 | Chinese herb composition for treating river crab shell ulcer disease and preparation method thereof |
-
2013
- 2013-08-08 CN CN2013103427663A patent/CN103432365A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 刘焕亮等: "《中国水产养殖学》", 31 January 2008 * |
| 薛怀宁等: "罗氏沼虾"黑壳病"的产生原因及防治对策", 《水产养殖》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147789A (en) * | 2015-10-23 | 2015-12-16 | 施瑞客（天津）生物技术有限公司 | Chinese herb composition for treating river crab shell ulcer disease and preparation method thereof |
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