CN111066958A - High-efficiency natural plant feed additive for protecting livers of cultured animals - Google Patents

High-efficiency natural plant feed additive for protecting livers of cultured animals Download PDF

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Publication number
CN111066958A
CN111066958A CN201911316416.3A CN201911316416A CN111066958A CN 111066958 A CN111066958 A CN 111066958A CN 201911316416 A CN201911316416 A CN 201911316416A CN 111066958 A CN111066958 A CN 111066958A
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parts
natural plant
feed additive
root
plant feed
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蒋蓉
王敏
曹建民
陈卓
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Wuxi Sanzhi Biotech Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K61/00—Culture of aquatic animals
    • A01K61/10—Culture of aquatic animals of fish
    • A01K61/13—Prevention or treatment of fish diseases
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y02A40/818—Alternative feeds for fish, e.g. in aquacultures

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Environmental Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Birds (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Insects & Arthropods (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Fodder In General (AREA)

Abstract

The invention provides a high-efficiency natural plant feed additive for protecting livers of cultured animals, which consists of the following components in parts by weight: 20-40 parts of kudzu root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-30 parts of codonopsis pilosula. The invention provides an efficient natural plant feed additive for protecting livers of cultured animals, which can improve the activity of fat metabolizing enzyme of the aquatic animals, improve the oxidation resistance of the livers and improve the growth performance of the aquatic animals, is a green and safe composition, enables the culture production to get rid of the problem of antibiotic dependence to the maximum extent, and realizes safe green and healthy culture.

Description

High-efficiency natural plant feed additive for protecting livers of cultured animals
Technical Field
The invention relates to a feed additive, in particular to a high-efficiency natural plant feed additive for protecting livers of cultured animals.
Background
In recent years, the aquaculture industry has been highly intensive and at the same time, the disease of aquatic animals is frequent due to the abuse of drugs in production, the high pursuit of yield and growth rate, the excess or imbalance of nutrients in feed and the use of some inferior and unconventional raw materials, wherein the damage to the liver or the diseases inducing liver disease is great. The liver is an important metabolic organ and detoxification organ of aquatic animals and has hematopoietic function. After hepatic steatosis, liver function is disordered, and absorption and metabolism of nutrient substances are influenced, so that growth of the fish is influenced, physique is weakened, disease resistance is reduced, the fish is greatly damaged in culture production, and fish diseases with imbalance in nutrition and metabolism, disorder of immune system and large outbreak are easy to occur. The enzymes of fish are produced and exported from the liver, fibrinogen, prothrombin and the like are substances constituting the liver, once the fish forms a liver disease, blood vessels of the fish are easy to rupture, blood is difficult to coagulate, and stress bleeding syndrome and even death in a large number occur once the fish is subjected to stress stimulation (net pulling, transportation, water temperature mutation, poor water quality and the like).
In the production, aiming at preventing and treating the liver injury of the fish body, nutrients are balanced mainly by feed proportioning, and anti-fat factors are used for strengthening liver metabolism in a matched mode or antibiotics are used for treating the liver injury in a large quantity. Common fat-resisting factors of the feed comprise highly unsaturated fatty acid, carnitine, lysine, phospholipid, bile acid, methionine, betaine, choline, vitamin or selenium and the like. These substances have a very good auxiliary effect on hepatic fat transformation and metabolism, but have little effect on liver injury, damaged cell repair and the like. The dependence on antibiotics for preventing and treating the liver diseases of aquatic animals brings good effect and huge economic benefit, but simultaneously has a plurality of disadvantages, such as: destroying normal microbial flora of aquatic animals to cause dysbiosis, and causing endogenous infection and superinfection; the increase of drug-resistant strains is promoted, so that the treatment is more difficult; antibiotics remain in aquatic animals, causing food safety problems and the like. It is therefore important to develop alternatives that are effective and avoid the above disadvantages. The natural plant product has the characteristics of no drug resistance, no residue, low adverse reaction, no pollution, no drug-induced disease initiation and the like, has obvious effect on preventing and treating liver diseases of human beings and various cultured animals, develops suitable Chinese herbal medicines for preventing and treating the liver health of aquatic animals, and has very wide application prospect.
Disclosure of Invention
The invention aims to provide an efficient natural plant feed additive for protecting the livers of cultured animals, which can improve the activity of fat metabolizing enzyme of the aquatic animals, improve the oxidation resistance of the livers and improve the growth performance of the aquatic animals, is a green and safe composition, enables the culture production to get rid of the problem of antibiotic dependence to the maximum extent, and realizes safe, green and healthy culture.
In order to solve the technical problems, the invention provides an efficient natural plant feed additive for protecting the livers of cultured animals, which comprises the following components in parts by weight: 20-40 parts of kudzu root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-30 parts of codonopsis pilosula.
Further, the natural plant feed additive is composed of the following components in parts by weight: 25-35 parts of kudzu root, 35-45 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-28 parts of codonopsis pilosula.
Further, the natural plant feed additive is composed of the following components in parts by weight: 30 parts of kudzuvine root, 40 parts of gynostemma pentaphylla, 8 parts of liquorice, 8 parts of baical skullcap root, 8 parts of Chinese angelica and 25 parts of pilose asiabell root.
The invention also provides a preparation method of the high-efficiency natural plant feed additive for protecting the livers of the cultured animals, which comprises the following steps: 20-40 parts of kudzuvine root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of baical skullcap root, 5-10 parts of Chinese angelica and 20-30 parts of pilose asiabell root are subjected to superfine grinding, sieved by a 400-mesh and 800-mesh sieve, and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
Further, in the method, the superfine grinding adopts a low-temperature superfine grinding process, the temperature is not higher than 60 ℃ in the grinding process, the natural plants are ground to micron level, the wall breaking is achieved, and the wall breaking rate is more than 90%.
Further, in the method, the superfine powder is sieved by a 600-800 mesh sieve.
The invention provides a feed containing a high-efficiency natural plant feed additive for protecting livers of cultured animals, which comprises 0.05-0.1% of the feed additive by weight.
The composition is prepared from natural plants including kudzuvine root, fiveleaf gynostemma herb, liquorice, baical skullcap root, Chinese angelica and pilose asiabell root, and the natural plants have a better liver protection effect in thousands of years of culture sediments. The combination of the natural plants is verified to strengthen the liver transformation function and repair the liver injury in time, the use is convenient, the method is simple, and the method is an excellent method for solving the liver injury of aquatic animals.
The invention has the following beneficial effects: because the invention is prepared by matching the kudzuvine root, the fiveleaf gynostemma herb, the liquorice, the baical skullcap root, the Chinese angelica and the pilose asiabell root, the combination of the kudzuvine root, the fiveleaf gynostemma herb, the liquorice, the baical skullcap root, the Chinese angelica and the pilose asiabell root has the function of cooperatively protecting the liver of the aquatic animal, can improve the activity of fat metabolism enzyme of the aquatic animal, reduce the fat deposition of organisms and the liver and improve the oxidation resistance of the liver, is a green and safe composition, enables the culture production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments.
The invention provides a high-efficiency natural plant feed additive for protecting livers of cultured animals, which consists of the following components in parts by weight: 20-40 parts of kudzu root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-30 parts of codonopsis pilosula.
In certain preferred embodiments, the high-efficiency natural plant feed additive is composed of the following components in parts by weight: 25-35 parts of kudzu root, 35-45 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-28 parts of codonopsis pilosula.
In certain more preferred embodiments, the high-efficiency natural plant feed additive is composed of the following components in parts by weight: 30 parts of kudzuvine root, 40 parts of gynostemma pentaphylla, 8 parts of liquorice, 8 parts of baical skullcap root, 8 parts of Chinese angelica and 25 parts of pilose asiabell root.
The invention also provides a preparation method of the high-efficiency natural plant feed additive for protecting the livers of the cultured animals, which comprises the following steps: 20-40 parts of kudzuvine root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of baical skullcap root, 5-10 parts of Chinese angelica and 20-30 parts of pilose asiabell root are subjected to superfine grinding, sieved by a 400-mesh and 800-mesh sieve, and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
In some preferred embodiments, the superfine grinding is performed by a low-temperature superfine grinding process, wherein the temperature in the grinding process is not higher than 60 ℃, and the natural plants are ground to micron level to achieve wall breaking, and the wall breaking rate is more than 90%. After being crushed in a superfine way, the mixture is sieved by a 600-sand 800-mesh sieve.
Some natural plants contain rich substances with antioxidant and free radical scavenging effects, such as plant polyphenol, chlorogenic acid, plant polysaccharide, etc., and these plants include Glycyrrhrizae radix, herba Gynostemmatis, radix Angelicae sinensis, etc.; puerarin has good repairing effect on liver cell damage, and radix Puerariae contains abundant puerarin; the plant polysaccharide has antioxidant effect and also has good immunity enhancing effect, and plants such as Scutellariae radix, Glycyrrhrizae radix, radix Codonopsis, etc. have good immunity enhancing effect; the components of plant flavone, alkaloid and the like contained in most plants have the effects of regulating metabolic balance and enhancing immunity of cultured animals. Therefore, the natural plant premix is an effective plant combination, and depending on various components, the natural plant premix takes liver and pancreas, which is a main organ of cultured animals, as a target organ, takes oxidation damage resistance and free radical damage resistance as well as liver cell structure and function repairing effects and immune defense system structure enhancing capability of cultured animals as main action mechanisms, and after cultured fishes are fed by the feed way, the effects of rapidly repairing the damaged liver and pancreas and enhancing the liver and pancreas functions are realized.
The Glycyrrhrizae radix is root and rhizome of perennial herb of Leguminosae. Modern pharmacological research considers that the liquorice contains various chemical components, and the main components comprise glycyrrhizic acid, liquiritin and the like. The chemical composition of licorice is very complex, and there are dozens of compounds separated from licorice so far, such as glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, neoisoliquiritin, liquiritigenin, isoliquiritigenin, glycyl alcohol, isoliquiritigenin, 7-methyl coumarine, umbelliferone, etc. A large number of researches show that glycyrrhizin and flavonoids are the most important physiological active substances in liquorice and mainly exist in the part inside the epidermis of liquorice root. Glycyrrhizin has adrenocortical hormone-like effect, and can enhance liver detoxicating ability. The flavonoids are polyphenol compounds, have different degrees of protective action on liver injury caused by various reasons, and have the main action mechanism related to antioxidation, enzyme action, tumor necrosis factor release inhibition, apoptosis action and the like. Can protect against liver injury by regulating some enzymes involved in cell division and proliferation, platelet aggregation, detoxification and inflammatory reactions.
Example 1
A high-efficiency natural plant feed additive for protecting the livers of cultured animals comprises the following components in parts by weight: 40 parts of kudzuvine root, 30 parts of fiveleaf gynostemma herb, 10 parts of liquorice, 10 parts of baical skullcap root, 10 parts of Chinese angelica and 30 parts of pilose asiabell root.
The kudzu root, the gynostemma pentaphylla, the liquorice, the scutellaria baicalensis, the angelica and the codonopsis pilosula are subjected to superfine grinding, sieved by a 400-mesh sieve and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
Taking 100kg of water-produced feed (such as TONGFEI group grass carp pellet feed, and Guangdong sea group Penaeus vannamei feed), adding adhesive into 100g of the obtained natural plant composition, and mixing with feed to obtain natural plant feed.
Example 2
A high-efficiency natural plant feed additive for protecting the livers of cultured animals comprises the following components in parts by weight: 20 parts of kudzuvine root, 50 parts of fiveleaf gynostemma herb, 5 parts of liquorice, 5 parts of baical skullcap root, 5 parts of Chinese angelica and 20 parts of pilose asiabell root.
The kudzu root, the gynostemma pentaphylla, the liquorice, the scutellaria baicalensis, the angelica and the codonopsis pilosula are subjected to superfine grinding, sieved by a 800-mesh sieve and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
Taking 100kg of water-produced feed (such as TONGFEI group grass carp pellet feed, and Guangdong sea group Penaeus vannamei feed), mixing 100g of the obtained natural plant composition with feed to obtain natural plant feed.
Example 3
A high-efficiency natural plant feed additive for protecting the livers of cultured animals comprises the following components in parts by weight: 30 parts of kudzuvine root, 45 parts of gynostemma pentaphylla, 8 parts of liquorice, 8 parts of baical skullcap root, 8 parts of Chinese angelica and 25 parts of pilose asiabell root.
The kudzu root, the gynostemma pentaphylla, the liquorice, the scutellaria baicalensis, the angelica and the codonopsis pilosula are subjected to superfine grinding, sieved by a 600-mesh sieve and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
Taking 100kg of water-produced feed (such as TONGFEI group grass carp pellet feed, and Guangdong sea group Penaeus vannamei feed), mixing 100g of the obtained natural plant composition with feed to obtain natural plant feed.
Example 4
A high-efficiency natural plant feed additive for protecting the livers of cultured animals comprises the following components in parts by weight: 30 parts of kudzuvine root, 40 parts of gynostemma pentaphylla, 8 parts of liquorice, 8 parts of baical skullcap root, 8 parts of Chinese angelica and 25 parts of pilose asiabell root.
The kudzu root, the gynostemma pentaphylla, the liquorice, the scutellaria baicalensis, the angelica and the codonopsis pilosula are subjected to superfine grinding, sieved by a 800-mesh sieve and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
Taking 100kg of water-produced feed (such as TONGFEI group grass carp pellet feed, and Guangdong sea group Penaeus vannamei feed), mixing 50g of the obtained natural plant composition with feed to obtain natural plant feed.
And (3) test results:
grass carp culture pond
1) Three pools were set: a blank control group and the fish pond of the invention.
Directly feeding grass carp with aquatic feed in the blank control group;
the fish pond of the present invention was fed with the feed prepared in examples 1-4.
2) Feeding mode: feeding with corresponding bait according to 3% of body weight every day for 2 weeks.
3) As a result: the activity of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase in blood serum of grass carp added with the composition is obviously lower than that of other control pools, and the immune indexes such as lipoprotein esterase activity, liver lipase activity, total lipase activity and the like in liver of grass carp added with the composition are obviously higher than those of other control pools.
The activity of each group of related enzymes
Figure BDA0002325944930000051
In summary, the following steps: the natural plant composition provided by the invention effectively improves the activity of fat metabolizing enzyme of aquatic animals, simultaneously improves the oxidation resistance of livers of the aquatic animals, has no toxic or side effect on components, is easy to degrade, has a simple production process, does not have any influence on the aquatic animals and the environment, and has a wide market prospect.
The above description is only an example of the present invention, and is not intended to limit the present invention, and it is obvious to those skilled in the art that various modifications and variations can be made in the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims (7)

1. The efficient natural plant feed additive for protecting the livers of the cultured animals is characterized by comprising the following components in parts by weight: 20-40 parts of kudzu root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-30 parts of codonopsis pilosula.
2. The high-efficiency natural plant feed additive for liver protection of farmed animals as claimed in claim 1, wherein the natural plant feed additive is composed of the following components in parts by weight: 25-35 parts of kudzu root, 35-45 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of scutellaria baicalensis, 5-10 parts of angelica and 20-28 parts of codonopsis pilosula.
3. The high-efficiency natural plant feed additive for liver protection of farmed animals as claimed in claim 1, wherein the natural plant feed additive is composed of the following components in parts by weight: 30 parts of kudzuvine root, 40 parts of gynostemma pentaphylla, 8 parts of liquorice, 8 parts of baical skullcap root, 8 parts of Chinese angelica and 25 parts of pilose asiabell root.
4. The method for preparing the high-efficiency natural plant feed additive for protecting the liver of the cultured animals according to claim 1, which comprises the following steps: 20-40 parts of kudzuvine root, 30-50 parts of gynostemma pentaphylla, 5-10 parts of liquorice, 5-10 parts of baical skullcap root, 5-10 parts of Chinese angelica and 20-30 parts of pilose asiabell root are subjected to superfine grinding, sieved by a 400-mesh and 800-mesh sieve, and mixed and stirred uniformly in a feed mixer to be used as an efficient natural plant feed additive for protecting the livers of cultured animals.
5. The preparation method according to claim 4, wherein the micronization process is carried out at a low temperature, wherein the temperature is not higher than 60 deg.C during micronization, and the natural plant is pulverized to micrometer level to achieve wall breaking rate of above 90%.
6. The method as claimed in claim 4, wherein the ultrafine powder is sieved through a 600-800 mesh sieve.
7. A feed containing a high-efficiency natural plant feed additive for protecting the livers of cultured animals is characterized in that: the feed comprises 0.05-0.1% by weight of the feed additive according to any one of claims 1-3.
CN201911316416.3A 2019-12-19 2019-12-19 High-efficiency natural plant feed additive for protecting livers of cultured animals Pending CN111066958A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114886048A (en) * 2022-04-06 2022-08-12 诺立(上海)生物工程有限公司 Compound conditioner for repairing liver pathological changes of aquatic animals

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Publication number Priority date Publication date Assignee Title
CN108042617A (en) * 2017-12-30 2018-05-18 众合发(北京)生物科技发展有限公司 A kind of natural plant composition for being used to improve aquatic livestock liver
CN108142729A (en) * 2016-12-05 2018-06-12 无锡三智生物科技有限公司 Feeding additive aquatic animal and its preparation method and application
CN109527266A (en) * 2017-09-21 2019-03-29 无锡三智生物科技有限公司 A kind of fish feed additive of quick reparation fish liver pancreas damage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108142729A (en) * 2016-12-05 2018-06-12 无锡三智生物科技有限公司 Feeding additive aquatic animal and its preparation method and application
CN109527266A (en) * 2017-09-21 2019-03-29 无锡三智生物科技有限公司 A kind of fish feed additive of quick reparation fish liver pancreas damage
CN108042617A (en) * 2017-12-30 2018-05-18 众合发(北京)生物科技发展有限公司 A kind of natural plant composition for being used to improve aquatic livestock liver

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114886048A (en) * 2022-04-06 2022-08-12 诺立(上海)生物工程有限公司 Compound conditioner for repairing liver pathological changes of aquatic animals

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