CN108142729A - Feeding additive aquatic animal and its preparation method and application - Google Patents
Feeding additive aquatic animal and its preparation method and application Download PDFInfo
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- CN108142729A CN108142729A CN201611102846.1A CN201611102846A CN108142729A CN 108142729 A CN108142729 A CN 108142729A CN 201611102846 A CN201611102846 A CN 201611102846A CN 108142729 A CN108142729 A CN 108142729A
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- liver
- radix glycyrrhizae
- sealwort
- bacterium powder
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The present invention relates to a kind of feeding additive aquatic animals, it is mainly made of following raw material:Pueraria lobata, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort, malt, ursodesoxycholic acid and composite bacillus bacterium powder.The production method of this feed is:Pueraria lobata, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort and malt are mixed, then crushed using broken wall disintegrating process;Then it is mixed evenly with ursodesoxycholic acid, composite bacillus bacterium powder.This feed addictive has apparent antioxidation, can effectively remove the free radical and toxin in aquatic livestock body;Liver cell is protected to be encroached on from free radical, the effect of boosting metabolism;Improve the liver function of aquatic livestock, prevent the hepar damnification caused by a variety of hepatotoxic agents;Increase the secretion of animal gall bladder bile acid, reduce bile cholesterol content;Liver and gallbladder protection improves organism immunity of aquatic livestock and disease resistance, improves digestibility, promotes aquatic livestock growth.
Description
Technical field
The present invention relates to aquatic products fields, more particularly to feeding additive aquatic animal and its preparation method and application.
Background technology
During aquaculture of aquatic animal, often the massive mortality caused by the reasons such as disease, is caused to vast cultivation dealer
Huge economic loss.Nowadays highdensity aquaculture model, high-plane of nutrition feed are fed, the liver of aquiculture animal
It is inevitably damaged, produces a series of new liver and liver and gall syndrome class disease.
Aquatic livestock liver is organa parenchymatosum maximum in animal body, participate in internal digestion, metabolism, excretion, removing toxic substances and
The multiple functions such as immune.Especially from the substance of gastrointestinal absorption, almost all enters liver, is synthesized, divided in liver
Solution, conversion, storage, therefore aquatic livestock liver is most easily involved by multiple pathogens, poisonous substance and immunopathogenesis, hepar damnification is
The lesion result of various aquatic livestock liver diseases.Clinically there are many factor, such as virus, biology, drug, can result in
Aquatic livestock hepar damnification.Aquatic livestock gall-bladder energy secretion of bile plays digestion, and the bile acid of secretion, is bile
Important component plays an important role in fat metabolism.Bile acid is primarily present in enterohepatic circulatory system, and passes through recycling,
Play certain protective effect.It has now been found that bile acid transports fat in enteron aisle, promote the absorption of fat.Aquatic livestock
Liver and gall syndrome, the lesion of liver class are the diseases that incidence is very high in recent years, generally popular in all parts of the country.How to subtract
The damage of few aquatic livestock liver repairs hepar damnification and reduces the incidence of liver and gall syndrome, carries out aquatic livestock liver protection shield
Courage this point becomes the emphasis of concern, so as to facilitate the present invention.
Invention content
The technical problem to be solved in the present invention is to provide a kind of feeding additive aquatic animal of liver and gallbladder protection, which adds
Add agent safe and reliable, toxic side effect is small, has no drug resistance, and absorptivity is high, will not generate hazard residue in aquatic livestock body.This feeding
Feed additives can protect cells from free radical infringement, the effect of boosting metabolism;Improve the liver function of aquatic livestock, prevention
Hepatic injury caused by a variety of hepatotoxic agents;Increase the secretion of animal gall bladder bile acid, reduce bile cholesterol content;Liver protection is protected
Courage improves immunity of organisms, digestibility is improved, so as to promote growth of animal.
To achieve the above object, the present invention provides a kind of feeding additive aquatic animal, it is mainly made of following raw material:Pueraria lobota
Root, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort, malt, ursodesoxycholic acid and composite bacillus bacterium powder.
In one embodiment, the parts by weight of each raw material of feeding additive aquatic animal of the invention are:15-25 parts of pueraria lobata,
20-25 parts of gynostemma pentaphylla, 15-20 parts of Radix Glycyrrhizae, 8-15 parts of sealwort, 15-18 parts of malt, 0.5-3 parts of ursodesoxycholic acid and compound gemma
2-15 parts of bacillus bacterium powder.
In one embodiment, the parts by weight of each raw material of feeding additive aquatic animal of the invention are:15-20 parts of pueraria lobata,
22-25 parts of gynostemma pentaphylla, 18-20 parts of Radix Glycyrrhizae, 10-15 parts of sealwort, 16-18 parts of malt, 1-2 parts of ursodesoxycholic acid and compound gemma bar
8-10 parts of bacterium bacterium powder.
In one embodiment, a kind of preparation method of the feeding additive aquatic animal of the present invention is provided, this method includes
Following steps:Step a. mixes pueraria lobata, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort and malt, then carries out powder using broken wall disintegrating process
It is broken;The mixture obtained after being crushed in step a with step b. is mixed equal with ursodesoxycholic acid, composite bacillus bacterium powder
It is even.
In one embodiment, the mixture obtained after being crushed in step a crosses sieves more than 400 mesh, it is therefore preferable to
The sieve of 800 mesh is crossed, is then mixed evenly with ursodesoxycholic acid, composite bacillus bacterium powder.
In one embodiment, a kind of application of the feeding additive aquatic animal of the present invention is provided, in aquatic feeds
Additive amount is the 0.025%-0.1% of feed relative.
In one embodiment, aquatic feeds are fish or shrimp feed.
Pueraria lobata is the dry root of legume pueraria lobata, also known as elegant jessamine in the present invention.Autumn, two season of winter excavation, take advantage of fresh-cut into
Sheet or fritter, it is dry.Property is sweet, pungent, cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in exterior syndrome hair
Heat, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.
Gynostemma pentaphylla replenishes qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, it is clearing heat and detoxicating the effect of, being capable of protecting liver and detoxication, lowering blood pressure and blood fat
Blood glucose.The main effective ingredient of gynostemma pentaphylla is gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids, a variety of
Vitamin, trace element, minerals etc..It is especially significant in efficacy to hyperlipidemia for treating hyperlipidemia, hypertension, hyperglycemia.
Cholesterol, triglyceride, low-density lipoprotein are significantly reduced, increasing high density lipoprotein, protection blood vessel cell prevent
Lipid is deposited in vascular wall, the effect of anti arteriosclerosis.
Radix Glycyrrhizae, main component have glycyrrhizic acid, liquiritin etc..The chemical composition of Radix Glycyrrhizae is extremely complex, so far from Radix Glycyrrhizae
In the compound isolated have glycyrrhizin, enoxolone, liquiritin, isoliquiritin, neoliquriitin, neoisoliquiritin, Radix Glycyrrhizae
The tens of kinds of chemical combination such as plain, isoliquiritigenin and licoricidin, glycyrol, isoglycyrol, 7- methylcoumarins essence, umbelliferone
Object, but these ingredients and quantity would generally be with the different and different of the factors such as the type of Radix Glycyrrhizae, planting area, collecting time.Largely
Research shows that, glycyrrhizin and Flavonoid substances are most important physiological activators in Radix Glycyrrhizae, are primarily present in licorice
Part within epidermis.
Sealwort is HUANGJING ZANYU CAPSULE also known as polygonatum sibiricum Redoute, and property is sweet, flat.Its rhizome part is used for medicinal purpose plant, is supported with tonifying Qi
The moon, invigorating the spleen, kidney-nourishing, the effect of moistening lung and production of body fluid.
Malt is grown in northern area more, is Preparation process of the ripening fruits of grass barley through germination drying
Product, property are sweet, flat.After wheat is soaked in water, preference temperature, humidity are kept, when young shoot length is to about 5mm, dries or low temperature is done
It is dry.Malt returns spleen, stomach, promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite.For treating dyspepsia in the traditional Chinese medical science, abdominal distention, spleen eating less,
Liver-depressed hypochondrium pain, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach.
Ursodesoxycholic acid main component 3 α, 7-5 β of beta-dihydroxy-cholanic acid (UDCA) are that a kind of chenodiol is organic
Compound, odorless, bitter.Medically for increasing bile acid secretion, and change bile component, reduce bile cholesterol and
Cholesterol ester, the cholesterol be conducive in gall stone gradually dissolve.
The composite bacillus bacterium powder:By bacillus subtilis, bafillus natto, bacillus licheniformis, wax bud
The strains such as spore bacillus collectively constitute, and are applied widely, and stability is good, and high temperature resistant, acidproof alkali ability are strong, and reproduction speed is faster
Bacterial strain.Composite bacillus mainly has the characteristics that following several:1st, after composite bacillus enters alimentary canal, rapidly by suspend mode shape
State is brought back to life, and is multiplied into the dominant population of high bacteria containing amount in a short time, consumes a large amount of oxygen in enteron aisle, and can generate hydrogen peroxide,
Bacteriocin establishes microecological balance, promotes the breeding beneficial to anaerobe, inhibits harmful bacteria (Escherichia coli, Salmonella bar
Bacterium) growth, so as to the stomach tract disease such as pre- anti-diarrhea, diarrhea.2nd, in quick reproductive process, a large amount of a variety of dimension lifes are generated
Element, organic acid, amino acid, protease (particularly alkali protease), carbohydrase, lipase, amylase, can degrading plant feeding
Complicated organic matter in material so as to promote to digest and assimilate, improves efficiency of feed utilization, prevents animal digestion bad, " feed occurs
The situations such as just ".3rd, safe and efficient, no drug residue has no toxic side effect, and can reduce the use of antibiotic medicine, and strengthen immunity improves
Aquatic livestock integrates disease resistance.
Said herbal medicine raw material is crushed using broken wall disintegrating process, and it is more than fineness to 400 mesh, preferably 800 mesh, then with
Ursodesoxycholic acid, composite bacillus bacterium powder are mixed evenly in feed mixing machine.According to the difference of aquatic livestock type and
The difference of residing health status is uniformly added by the weight ratio of 0.025%-0.1% in aquatic animal feed.Water in the present invention
Product includes being divided into fish, shrimp, crab, four major class of shellfish.
Compared with the prior art the present invention, has the following advantages:
1st, general Chinese herbal medicine smashing fineness in 300 mesh hereinafter, between 150-200 mesh.Natural plants have thicker cell
Wall, if not broken wall, the active ingredient of the inside cannot discharge well.The present invention is crossed more than 400 mesh using broken wall disintegrating process
Sieve preferably crosses 800 mesh, and sporoderm-broken rate reaches more than 95%, ensures that active ingredient can be more preferably released in Chinese herbal medicine.
2nd, the present invention is rich in active ingredients such as flavones, saponin(e, polysaccharide, without any antibiotic.
3rd, the present invention significantly improves the bioavilability of each natural vegetable Chinese herbal medicine by scientific compatibility.
4th, the present invention can grow whole use in aquatic livestock, and no drug residue has no drug resistance, safe and efficient.
5th, the present invention is resistant to the conditions such as the high temperature and pressure in feed processing, without losing its natural effect.
The invention has the advantages that:
1st, the present invention can promote lipid-metabolism, prevent fatty liver.It can inhibit peroxidatic reaction of lipid and to other simultaneously
The damage of cell.
2nd, the present invention can stimulate the biosynthesis of aquatic livestock liver cell internal protein, promote repairing for damaged liver cell
It is multiple.
3rd, the method can significantly improve the secretions of animal gall bladder bile acid, reduce triglycerides, cholesterol level in blood.
4th, the present invention has apparent antioxidation, can improve the activity of SOD, CAT etc. in blood, effectively removes internal
Free radical and toxin.
5th, the present invention can improve food conversion ratio, and promote growth of animal, increase fanning economics.
6th, the present invention can improve the fish body bodily form and body colour.
Description of the drawings
It, below will be to needed in the embodiment in order to illustrate more clearly of the technical solution in the embodiment of the present application
Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only some embodiments described in the application, right
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings
Its attached drawing.
Fig. 1 is to use the additive of the present invention in embodiment 1 in grass carp, carp and bream feed for fish growth rate
Influence figure;
Specific embodiment
In order to which art technology field personnel is made to more fully understand the technical solution in the application, below in conjunction with following knot
Closing embodiment, the invention will be further described, it is clear that and described embodiments are only a part of embodiments of the present application, without
It is whole embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not before creative work is made
The all other embodiment obtained is put, should all belong to the range of the application protection.
Embodiment 1
18 parts of pueraria lobata, 23 parts of gynostemma pentaphylla, 18 parts of Radix Glycyrrhizae, 12 parts of sealwort, 18 parts of malt, 1 part of ursodesoxycholic acid, compound gemma
10 parts of bacillus bacterium powder.
Said herbal medicine raw material is placed in pulverizer and is crushed, 800 mesh is crossed, then whole raw materials is uniformly mixed, are pressed
0.025% weight ratio, which is added in one feed factory grass carp of Jiangsu, carp, bream feed, to be fed.
0.025% this product is added in feed, is tracked three months in pond after use, through aquatic livestock battalion of University Of Suzhou
Supporting proves with the experiment of feed research department:The product can effectively facilitate fish growth, improve food conversion ratio, reduce feed coefficient.
It can be effectively promoted fat, bile acid biosynthesis simultaneously, prevent fatty liver and hepatic necrosis from occurring.It is raised in grass carp, carp and bream
This product that weight ratio is 0.025% is added in material respectively, as shown in Figure 1, the instantaneous growth rate of experimental group is respectively control group
133%, 112%, 124%.
Embodiment 2
18 parts of pueraria lobata, 23 parts of gynostemma pentaphylla, 18 parts of Radix Glycyrrhizae, 12 parts of sealwort, 18 parts of malt, 1 part of ursodesoxycholic acid, compound gemma
10 parts of bacillus bacterium powder.
Said herbal medicine raw material is placed in pulverizer and is crushed, 800 mesh are crossed, then by whole raw materials in feed mixing machine
It is uniformly mixed, is added in one feed factory feed of grass carp of Zhejiang Huzhou by 0.03% weight ratio and feeds.
After feeding a period of time by weight addition this product 0.03% in feed of grass carp, grass carp, liver face are dissected
Color is scarlet, illustrates that this product promotes fish body lipid, bile acid biosynthesis, liver and gallbladder protection, reduces generation and the enteron aisle of fatty liver
The accumulation of external fat;The fish body bodily form is good, reduces the generation of " oldwife ";Fish body body colour is also preferable.
In the Grass Carp Juveniles stage, the development of Liver of Ctenopharyngodon Idellus can be promoted well using this product, improve liver function.If
Liver damage adds the promotion of this product weight ratio to 0.05%-0.06% in feed of grass carp, can make damaged liver cell in this way
It repairs in time, liver can be made to be clearly better within 7-10 days.Monthly using this additive by weight 0.05% health care 2 times, every time 3
My god, the generation of liver diseases can be greatly reduced, liver and gallbladder protection improves fish body immunity and disease resistance.
Embodiment 3
18 parts of pueraria lobata, 23 parts of gynostemma pentaphylla, 18 parts of Radix Glycyrrhizae, 12 parts of sealwort, 18 parts of malt, 1 part of ursodesoxycholic acid, compound gemma
10 parts of bacillus bacterium powder.
Said herbal medicine raw material is placed in pulverizer and is crushed, 800 mesh is crossed, then whole raw materials is uniformly mixed, are pressed
0.025% weight ratio, which is added in mono- feed factory crucian carp feeds of Jiangsu great Feng, to be fed, and tracks this cultivating pool one month.
By weight 0.025% addition this product in crucian carp feed, liver, gall-bladder color are normal, enteron aisle external fat product
It is tired less, greatly reduce the generation of crucian disease, fish body body colour is preferable.This product 0.05% health care by weight 2 times is monthly used,
3-5 days every time, liver and gallbladder protection can be played the role of, fish body immunity and disease resistance is improved, greatly reduce crucian gill bleeding disease
The generation of disease.
Embodiment 4
18 parts of pueraria lobata, 23 parts of gynostemma pentaphylla, 18 parts of Radix Glycyrrhizae, 12 parts of sealwort, 18 parts of malt, 1 part of ursodesoxycholic acid, compound gemma
10 parts of bacillus bacterium powder.
Said herbal medicine raw material is placed in pulverizer and is crushed, 800 mesh is crossed, whole raw materials is then placed in feed mixing machine
In be uniformly mixed, be added in one feed factory bream feed of Zhejiang Deqing by 0.025% weight ratio and feed, Follow-up observation one
Month.
After 0.025% feeding of this product weight ratio is added in bream feed, fish liver color is normal, and mucous secretion is just
Often, whole finish is good, particularly can normally go out " hot water fish ".
Embodiment 5
18 parts of pueraria lobata, 23 parts of gynostemma pentaphylla, 18 parts of Radix Glycyrrhizae, 12 parts of sealwort, 18 parts of malt, 1 part of ursodesoxycholic acid, compound gemma
10 parts of bacillus bacterium powder.
Said herbal medicine raw material is placed in pulverizer and is crushed, 800 mesh is crossed, then whole raw materials is uniformly mixed, are pressed
0.03% weight ratio, which is added in one feed factory penaeus vannamei boone feed of Jiangsu Rudong, to be fed, Follow-up observation two months.
This batch cultivates Penaeus Vannmei, and hepatopancrease is clear, and this product promotes lipid, bile acid biosynthesis, can repair in time
Multiple wounded hepatocytes, greatly reduce the generation of the situations such as hepatic necrosis.
From examples detailed above it is found that the present invention is in aquaculture process, there is apparent antioxidation, can effectively remove
Internal free radical and toxin;Protect cells from free radical infringement, the effect of boosting metabolism;Improve the liver of aquatic livestock
Function prevents the hepatic injury caused by a variety of hepatotoxic agents;Increase the secretion of animal gall bladder bile acid, reduce bile cholesterol and contain
Amount;Liver and gallbladder protection improves organism immunity of aquatic livestock, improves digestibility, promotes aquatic livestock growth.
It should be understood that the present invention disclosed is not limited only to specific method, scheme and the substance of description, because these
It is alterable.It will also be understood that terminology used here just for the sake of describe the purpose of specific embodiment scheme rather than
It is intended to limit the scope of the invention, the scope of the present invention is limited solely by appended claim.
Those skilled in the art, which will also be appreciated that or be able to confirm that, uses no more than routine experiment, institute herein
The many equivalents of the specific embodiment of the present invention stated.These equivalents are also contained in appended claim.
Claims (8)
1. feeding additive aquatic animal, it is characterised in that it is mainly made of following raw material:Pueraria lobata, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort, wheat
Bud, ursodesoxycholic acid and composite bacillus bacterium powder.
2. the feeding additive aquatic animal according to claim 1, it is characterised in that the parts by weight of each raw material are:Pueraria lobata 15-25
Part, 20-25 parts of gynostemma pentaphylla, 15-20 parts of Radix Glycyrrhizae, 8-15 parts of sealwort, 15-18 parts of malt, 0.5-3 parts of ursodesoxycholic acid and compound bud
2-15 parts of spore bacillus bacterium powder.
3. the feeding additive aquatic animal according to claim 2, it is characterised in that the parts by weight of each raw material are:Pueraria lobata 15-20
Part, 22-25 parts of gynostemma pentaphylla, 18-20 parts of Radix Glycyrrhizae, 10-15 parts of sealwort, 16-18 parts of malt, 1-2 parts of ursodesoxycholic acid and compound bud
8-10 parts of spore bacillus bacterium powder.
4. according to the preparation method of any one of the claim 1-3 feeding additive aquatic animals, it is characterised in that including following step
Suddenly:
Step a. mixes pueraria lobata, gynostemma pentaphylla, Radix Glycyrrhizae, sealwort and malt, is then crushed using broken wall disintegrating process;
The mixture that step b. is obtained after being crushed in step a is mixed equal with ursodesoxycholic acid, composite bacillus bacterium powder
It is even.
5. the preparation method according to claim 4, it is characterised in that:The mixture obtained after being crushed in step a crosses 400
Then sieve more than mesh is mixed evenly with ursodesoxycholic acid, composite bacillus bacterium powder.
6. the preparation method according to claim 5, it is characterised in that:The mixture obtained after being crushed in step a crosses 800
Purpose is sieved.
7. according to the application of the feeding additive aquatic animal of any one of claim 1-3, additive amount is in aquatic feeds
The 0.025%-0.1% of feed relative.
8. the application according to claim 7, the aquatic feeds are fish or shrimp feed.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111066958A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for protecting livers of cultured animals |
CN111066957A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for repairing intestinal injury of aquatic animals |
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CN102067955A (en) * | 2010-12-13 | 2011-05-25 | 苏州大学 | Compound feed for enhancing physiological functions of intestinal mucosa and liver/pancreas cells of fishes |
CN102696923A (en) * | 2012-06-15 | 2012-10-03 | 天津昌农科技有限责任公司 | Premix compound for aquatic products, application thereof in feed additive, and batch thereof |
CN103749986A (en) * | 2014-01-25 | 2014-04-30 | 杨洪星 | Animal feed additive and preparation method thereof |
CN104686833A (en) * | 2015-01-30 | 2015-06-10 | 蚌埠市淮景绿湾生态农业有限公司 | High-yield and disease-resistant turtle feed |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102067955A (en) * | 2010-12-13 | 2011-05-25 | 苏州大学 | Compound feed for enhancing physiological functions of intestinal mucosa and liver/pancreas cells of fishes |
CN102696923A (en) * | 2012-06-15 | 2012-10-03 | 天津昌农科技有限责任公司 | Premix compound for aquatic products, application thereof in feed additive, and batch thereof |
CN103749986A (en) * | 2014-01-25 | 2014-04-30 | 杨洪星 | Animal feed additive and preparation method thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111066958A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for protecting livers of cultured animals |
CN111066957A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for repairing intestinal injury of aquatic animals |
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