CN101991026B - Complex immunity reinforcing agent for improving stress resistance of black carp and preparation method thereof - Google Patents
Complex immunity reinforcing agent for improving stress resistance of black carp and preparation method thereof Download PDFInfo
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- CN101991026B CN101991026B CN2010105631219A CN201010563121A CN101991026B CN 101991026 B CN101991026 B CN 101991026B CN 2010105631219 A CN2010105631219 A CN 2010105631219A CN 201010563121 A CN201010563121 A CN 201010563121A CN 101991026 B CN101991026 B CN 101991026B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention relates to a freshwater fish feed additive, in particular to a complex immunity reinforcing agent for a black carp. The immunity reinforcing agent for improving the stress resistance of a black carp comprises the following components in percent by weight: 10-20 percent of dangshen polysaccharide, 10-15 percent of isatis root, 15-20 percent of astragalus root polysaccharide, 5-10 percent of mangiferin, 5-10 percent of rose roxburghii tratt polysaccharide, 0.5-5 percent of vitamin C, 1-6 percent of vitamin E and 20-40 percent of wheat-middlings. The complex immunity reinforcing agent can be used as a feed additive for making up the defects presented by the black carp in the stress state, improving the stress resisting capacity of the black carp and the utilization rate of the feed, lowering the feed coefficients, reducing the damage caused by the stress, reinforcing the immunity of the black carp and increasing the survival rate.
Description
[technical field]
The present invention relates to a kind of fresh water fish feed additive, relate in particular to a kind of composite immune reinforcing agent that is used for black carp.
[background technology]
Black carp (Mylopharyngodon piceus) belongs to Cypriniformes (Cypriniformes), Cyprinidae (Cyprinidae), Mylopharyngodon (Mylopharyngodon), has another name called blue, blue or green enormous legendary fish, which could change into a roc, blue or green Anhui, spiral shell green grass or young crops, is one of four famous large Chinese carps of China.Individual big because of it, growth rapidly, meat fertilizer is tender, delicious fat is beautiful, except that containing abundant protein, fat, also contains trace elements such as abundant selenium, iodine in the flesh of fish, and anti-ageing, antitumaous effect is arranged, and is top grade in the fresh-water fishes, enjoys consumers in general's welcome.Black carp perches the middle lower floor at water body more, does not generally swim to the water surface, maximum characteristics are that power is big, property just, the happiness low light level, the unusual vigilance of sound to external world.Especially draw in the net, transportation, water temperature sudden change, change of water quality, cultivation density are too high, malnutrition and outside stimulus etc. make fish be in " stress situation "; Can occur the requirement of some nutrition is increased rapidly; Abwehrkraft des Koepers descends; Have a strong impact on ingesting, growing of black carp, thereby cause the generation of disease, even the higher phenomenon of the death rate occurs.
China is the abundant big country of Chinese herbal medicine resource, has advantages such as pure natural, efficient, drug residue free and drug resistance, and kind is various, and its effect is respectively arranged.For example wilsonii, Radix Isatidis, the Radix Astragali, Radix Codonopsis etc. all have anti-stress effect, improve food conversion ratio, and improve immunity of organisms, promote performances such as growth.The extract of Radix Codonopsis---Codonopsis pilosula polysaccharide has many-side biologically active preferably, and it be innocuous substance for a toxicological experiment proof, and modern pharmacological research shows, have the immunity of organisms of adjusting, anti-ageing, anti-anoxic, resist stress, effect such as anti-oxidant.
Radix Isatidis is the root of cruciferae isatis, has effect clearing heat and detoxicating, cool blood.Contain compositions such as many sinigrins, indigo red, indigo-blue, indican, adenosine, palmitic acid and several amino acids in the isatis root extract, have characteristics such as antibiotic, antiviral, anti-inflammatory, adjusting immunologic function.
The Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus, belongs to perennial plant, and the growth plant height can reach about 40～80cm, mainly is distributed in the northwest China and the Mongolian plat southern areas of cool temperature zone.The effective active composition of Astragalus Root P.E is an astragalus polyose, has raise immunity, anti-stress, promote organism metabolism, protects the liver, extensively pharmacological action such as antibiotic, anti-viral.
Mangiferin is a kind of carbonic acid glycosides of tetrahydroxy pyrrone; Belong to two benzene pyrrones compounds; In various plants, exist, like the Anacardiaceae mango, the leaf of almond, fruit, bark, gentianaceae plant; The liliaceous plant wind-weed and Polypodiaceae plant balt pyrrosia herb etc. have anti-oxidant, antibacterium, antiviral, immunological regulation and anti-ly stress wait many-sided physiological activity.
Rosa roxburghii is the fruit of rosaceous plant; Be distributed in China southwest, among the people its fruit and root be used as medicine, have digestion-promoting spleen-invigorating, astringing to arrest diarrhea, relieving summer-heat, raising immunologic function; Be rich in the polysaccharide composition in the fruit of Grossularia burejensis Berger; Have tangible anti-stress effect like the Rosa roxburghii polysaccharide, can make body secretory antibody increased functionality, strengthen the effect of non-specific immune function and humoral immune function.
Vitamin is the indispensable nutriment of aquatic livestock; Be not only the most basic constituent of fish normal growth like vitamin A, C, E etc.; Also can strengthen the special and nonspecific immune response of fish; All have enhance immunity power and resistance against diseases, can improve the multiple anti-stress ability of fish body simultaneously.But up to now, about improve black carp anti-stress the research of composite immune reinforcing agent aspect also do not appear in the newspapers.Therefore develop and a kind ofly can either improve the black carp anti-stress ability, can strengthen the composite immune reinforcing agent of fish body immunity again, significant to intensive culture and the sustainable development of black carp.
[summary of the invention]
The purpose of this invention is to provide a kind of feed addictive that can be used as and remedy black carp in deficiency that stress situation showed; Improve black carp anti-stress ability; Improve efficiency of feed utilization, reduce feed coefficient; The injury that minimizing stress be brought, the immunopotentiator of enhancing black carp immunity of organisms, raising survival rate.
For realizing above-mentioned purpose, the technical scheme that the present invention taked is following:
A kind of improve black carp anti-stress immunopotentiator; By percentage to the quality, comprise Codonopsis pilosula polysaccharide 10～20%, Radix Isatidis 10～15%, astragalus polyose 15～20%, mangiferin 5～10%, Rosa roxburghii polysaccharide 5～10%, vitamin C 0.5～5%, vitamin E 1～6%, inferior powder 20～40%.
Preferably, by percentage to the quality, comprise Codonopsis pilosula polysaccharide 15%, Radix Isatidis 12%, astragalus polyose 18%, mangiferin 8%, Rosa roxburghii polysaccharide 7%, vitamin C 3.5%, vitamin E 2.5%, inferior powder 34%.
A kind of prepare above-mentioned raising black carp anti-stress the method for immunopotentiator, said raw material is pulverized through micronizer, all through 200 purpose screen clothes, after mixing, promptly get immunopotentiator of the present invention.
Above-mentioned raising black carp anti-stress the method for using of immunopotentiator, the percentage by weight according to 0.5～1% adds it in black carp feed to, mixes to get final product.
Compared with prior art, the present invention has following advantage:
(1) constituent of the present invention can strengthen the anti-stress ability of black carp, and effectively the generation of disease is cultured in prevention, promotes growth.
(2) the present invention is good as the feed addictive performance, and the ratio according to 0.5～1% in feed is added, and obviously improves the non-specific immunity of black carp, the performance of enhancing body.
(3) the present invention effectively improves the breed survival rate of black carp, effectively improves the output of black carp, reduces aquaculture cost, helps developing the large-scale cultivation of black carp, thereby further promotes the sound development of black carp aquaculture, satisfies the demand in market.
(4) raw material sources of the present invention are easy, and operation is simple, reasonable mixture ratio, with low cost.
[specific embodiment]
Embodiment 1
Take by weighing Codonopsis pilosula polysaccharide 18kg, Radix Isatidis 13kg, astragalus polyose 16kg; Mangiferin 6kg, Rosa roxburghii polysaccharide 8kg, vitamin C 3kg; Vitamin E 4kg, inferior powder 32kg pulverizes (the bright rich equipment in Wuhan Co., Ltd produces) through micronizer; All through 200 purpose screen clothes, the ratio according to 1% after mixing is added in the black carp mixed feed.
Embodiment 2
Take by weighing Codonopsis pilosula polysaccharide 15kg, Radix Isatidis 12kg, astragalus polyose 18kg; Mangiferin 8kg, Rosa roxburghii polysaccharide 7kg, vitamin C 3.5kg; Vitamin E 2.5kg, inferior powder 34kg pulverizes (production of Hubei San Jiang Co., Ltd) through micronizer; All through 200 purpose screen clothes, the ratio according to 0.8% after mixing is added in the black carp mixed feed.
Embodiment 3
Take by weighing Codonopsis pilosula polysaccharide 16kg, Radix Isatidis 14kg, astragalus polyose 18kg; Mangiferin 5kg, Rosa roxburghii polysaccharide 6kg, vitamin C 4kg; Vitamin E 5kg, inferior powder 32kg pulverizes (production of Hubei San Jiang Co., Ltd) through micronizer; All through 200 purpose screen clothes, after mixing, the ratio according to 0.5% is added in the black carp mixed feed.
Embodiment 4
Take by weighing Codonopsis pilosula polysaccharide 10kg, Radix Isatidis 15kg, astragalus polyose 15kg; Mangiferin 5kg, Rosa roxburghii polysaccharide 10kg, vitamin C 0.5kg; Vitamin E 6kg, inferior powder 40kg pulverizes (production of Hubei San Jiang Co., Ltd) through micronizer; All through 200 purpose screen clothes, after mixing, the ratio according to 0.7% is added in the black carp mixed feed.
Embodiment 5
Take by weighing Codonopsis pilosula polysaccharide 20kg, Radix Isatidis 10kg, astragalus polyose 20kg; Mangiferin 10kg, Rosa roxburghii polysaccharide 5kg, vitamin C 5kg; Vitamin E 1kg, inferior powder 20kg pulverizes (production of Hubei San Jiang Co., Ltd) through micronizer; All through 200 purpose screen clothes, after mixing, the ratio according to 0.6% is added in the black carp mixed feed.
Embodiment 6
In July, 2009, cultivation base, Fanyu District sea-gull island experimentized in the Guangzhou, and experiment is set to 4 processed group, is respectively control group, embodiment 1, embodiment 2, embodiment 3.Wherein " control group " adopt not have to add resist stress the black carp mixed feed of immunopotentiator; Embodiment 1, embodiment 2, embodiment 3 have added 1%, 0.8% and 0.5% patent of invention immunopotentiator on the basis of control group, it is formed according to above instance, and each processing is provided with 6 repetitions; Throw something and feed according to being satiated with food 3 every day; Be 60 days experimental period, after experiment finishes, measures the black carp growth indexes; And get serum and the head-kidney macrophage carries out the analysis of nospecific immunity index, its experimental result such as table 1 and table 2.
The immunopotentiator of table 1. the present invention preparation to black carp grow, ingest, the influence of feed coefficient and survival rate
| Processed group | Control group | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Average weight gain amount (g) | 5.54a | 6.12b | 6.41b | 6.67c |
| Average growth rate (%) | 47.6±0.67a | 52.67±0.97b | 54.91±1.44b | 57.31±0.95c |
| Grazing rate (%.d -1) | 1.13±0.14a | 1.08±0.09b | 0.96±0.13b | 0.98±0.16b |
| Feed coefficient | 1.64±0.78a | 1.45±0.04b | 1.26±1.1c | 1.23±0.08c |
| Survival rate (%) | 75a | 92.5b | 95c | 93.3b |
The immunopotentiator of table 2. the present invention preparation is to the influence of black carp immunity of organisms
Can know by experimental result, the present invention can significantly improve black carp anti-stress ability, strengthen the black carp immunity of organisms, improve survival rate, thereby improve efficiency of feed utilization, reduce feed coefficient, the injury that minimizing stress be brought.
Claims (4)
- One kind improve black carp anti-stress immunopotentiator; It is characterized in that by percentage to the quality, composed of the following components: Codonopsis pilosula polysaccharide 10～20%, Radix Isatidis 10～15%, astragalus polyose 15～20%, mangiferin 5～10%, Rosa roxburghii polysaccharide 5～10%, vitamin C 0.5～5%, vitamin E 1～6%, inferior powder 20～40%.
- 2. raising as claimed in claim 1 black carp anti-stress immunopotentiator, it is characterized in that by percentage to the quality, comprise Codonopsis pilosula polysaccharide 15%, Radix Isatidis 12%; Astragalus polyose 18%, mangiferin 8%, Rosa roxburghii polysaccharide 7%; Vitamin C 3.5%, vitamin E 2.5%, inferior powder 34%.
- One kind prepare according to claim 1 or claim 2 raising black carp anti-stress the method for immunopotentiator, it is characterized in that said raw material is pulverized through micronizer, all through 200 purpose screen clothes, after mixing, promptly get immunopotentiator.
- A raising black carp according to claim 1 or claim 2 anti-stress the method for using of immunopotentiator, it is characterized in that percentage by weight according to 0.5～1%, it is added in the black carp feed, mix and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010105631219A CN101991026B (en) | 2010-11-24 | 2010-11-24 | Complex immunity reinforcing agent for improving stress resistance of black carp and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105631219A CN101991026B (en) | 2010-11-24 | 2010-11-24 | Complex immunity reinforcing agent for improving stress resistance of black carp and preparation method thereof |
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| CN101991026A CN101991026A (en) | 2011-03-30 |
| CN101991026B true CN101991026B (en) | 2012-02-29 |
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511697B (en) * | 2012-01-13 | 2013-01-02 | 河南工业大学 | Special composite immune-enhancer for Yellow River carp |
| CN103652381B (en) * | 2012-09-06 | 2015-12-16 | 山东安源水产股份有限公司 | The composite immune reinforcing agent of the young children's ginseng of a kind of stichopus japonicus |
| CN104187090B (en) * | 2014-08-08 | 2017-05-03 | 广东海因特生物技术集团有限公司 | Chinese herbal medicine composite feed additive for preventing and controlling swimming (i.e. floating, roaming or stopping underwater) of Japanese sea basses |
| CN104206903B (en) * | 2014-09-02 | 2018-08-10 | 北京爱绿生物科技有限公司 | A kind of Chinese herbal medicine Antistress agent composition and its application |
| CN104664140A (en) * | 2014-12-23 | 2015-06-03 | 河南牧业经济学院 | Poultry feed additive |
| CN104705495A (en) * | 2015-03-31 | 2015-06-17 | 江西中成人药业有限公司 | Special traditional Chinese medicine polysaccharide feed additive for pets |
| CN107468682B (en) * | 2015-07-24 | 2021-03-02 | 华中农业大学 | Application of mangiferin in preparation of antiviral drugs |
| CN106689808A (en) * | 2016-12-09 | 2017-05-24 | 陈周英 | Feed for enhancing immunity of black carps |
| CN107712367A (en) * | 2017-11-29 | 2018-02-23 | 衡阳县福茂农林生态有限公司 | Feed addictive, preparation method and the application method of pig anti-heat stress |
| CN107691826A (en) * | 2017-11-29 | 2018-02-16 | 衡阳县福茂农林生态有限公司 | Feed addictive, preparation method and the application method of fish anti-heat stress |
| CN107873975A (en) * | 2017-11-29 | 2018-04-06 | 衡阳县福茂农林生态有限公司 | Feed addictive, preparation method and the application method of beef cattle anti-heat stress |
| CN107712427A (en) * | 2017-11-29 | 2018-02-23 | 衡阳县福茂农林生态有限公司 | Feed addictive, preparation method and the application method of chicken anti-heat stress |
| CN108185218A (en) * | 2017-12-19 | 2018-06-22 | 天邦食品股份有限公司 | A kind of dedicated feed addictive of grass carp protect liver |
| CN110463632A (en) * | 2018-05-11 | 2019-11-19 | 南京农业大学 | A kind of natural additive improving leech anti-heat stress ability |
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