CN103402989B - 四唑化合物及其制备和使用方法 - Google Patents

四唑化合物及其制备和使用方法 Download PDF

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Publication number
CN103402989B
CN103402989B CN201280010890.3A CN201280010890A CN103402989B CN 103402989 B CN103402989 B CN 103402989B CN 201280010890 A CN201280010890 A CN 201280010890A CN 103402989 B CN103402989 B CN 103402989B
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alkyl
group
cycloalkyl
compound
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English (en)
Chinese (zh)
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CN103402989A (zh
Inventor
H·J·戴克
T·D·帕琳
S·M·克拉姆普
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Larimar Therapeutics Inc
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Zafgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280010890.3A 2011-01-26 2012-01-26 四唑化合物及其制备和使用方法 Expired - Fee Related CN103402989B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161436265P 2011-01-26 2011-01-26
US61/436,265 2011-01-26
PCT/US2012/022721 WO2012103333A1 (en) 2011-01-26 2012-01-26 Tetrazole compounds and methods of making and using same

Publications (2)

Publication Number Publication Date
CN103402989A CN103402989A (zh) 2013-11-20
CN103402989B true CN103402989B (zh) 2016-04-06

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CN201280010890.3A Expired - Fee Related CN103402989B (zh) 2011-01-26 2012-01-26 四唑化合物及其制备和使用方法

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US (1) US9321740B2 (https=)
EP (1) EP2668169B1 (https=)
JP (1) JP6058557B2 (https=)
KR (1) KR20140006888A (https=)
CN (1) CN103402989B (https=)
BR (1) BR112013018771A2 (https=)
CA (1) CA2825408A1 (https=)
MX (1) MX344238B (https=)
WO (1) WO2012103333A1 (https=)

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CN105228610A (zh) 2013-03-14 2016-01-06 扎夫根股份有限公司 治疗肾疾病和其它病症的方法
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
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JP2019052115A (ja) * 2017-09-15 2019-04-04 国立研究開発法人理化学研究所 医薬組成物
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Also Published As

Publication number Publication date
MX2013008656A (es) 2014-01-17
WO2012103333A1 (en) 2012-08-02
US9321740B2 (en) 2016-04-26
BR112013018771A2 (pt) 2019-09-17
JP2014503591A (ja) 2014-02-13
JP6058557B2 (ja) 2017-01-11
MX344238B (es) 2016-12-07
EP2668169B1 (en) 2017-11-15
KR20140006888A (ko) 2014-01-16
CN103402989A (zh) 2013-11-20
US20130331420A1 (en) 2013-12-12
EP2668169A1 (en) 2013-12-04
CA2825408A1 (en) 2012-08-02

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