CN103360450B - 人参皂苷c-k的两种晶型及其制备方法 - Google Patents

人参皂苷c-k的两种晶型及其制备方法 Download PDF

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Publication number
CN103360450B
CN103360450B CN201210093293.3A CN201210093293A CN103360450B CN 103360450 B CN103360450 B CN 103360450B CN 201210093293 A CN201210093293 A CN 201210093293A CN 103360450 B CN103360450 B CN 103360450B
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China
Prior art keywords
crystal formation
ginsenoside
crystal form
ginseng saponin
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201210093293.3A
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English (en)
Chinese (zh)
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CN103360450A (zh
Inventor
任国宾
代常亮
陈金瑶
陈锋
齐明辉
朱文明
洪鸣凰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Hisun Pharmaceutical Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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Publication date
Priority to CN201610297739.2A priority Critical patent/CN105949264A/zh
Application filed by Zhejiang Hisun Pharmaceutical Co Ltd filed Critical Zhejiang Hisun Pharmaceutical Co Ltd
Priority to CN201210093293.3A priority patent/CN103360450B/zh
Priority to US14/389,345 priority patent/US9643992B2/en
Priority to EP13772541.2A priority patent/EP2835377B1/en
Priority to PCT/CN2013/073562 priority patent/WO2013149571A1/zh
Priority to JP2015502084A priority patent/JP2015511608A/ja
Priority to IN1941MUN2014 priority patent/IN2014MN01941A/en
Publication of CN103360450A publication Critical patent/CN103360450A/zh
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Publication of CN103360450B publication Critical patent/CN103360450B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201210093293.3A 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法 Active CN103360450B (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201210093293.3A CN103360450B (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法
CN201610297739.2A CN105949264A (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法
EP13772541.2A EP2835377B1 (en) 2012-04-01 2013-04-01 New crystal form h of ginsenoside c-k and method for preparing same
PCT/CN2013/073562 WO2013149571A1 (zh) 2012-04-01 2013-04-01 人参皂苷c-k的两种晶型及其制备方法
US14/389,345 US9643992B2 (en) 2012-04-01 2013-04-01 Two crystal forms of ginsenoside C-K and method for preparing same
JP2015502084A JP2015511608A (ja) 2012-04-01 2013-04-01 ジンセノシドｃ−ｋの２つの結晶形およびその製造方法
IN1941MUN2014 IN2014MN01941A (https=) 2012-04-01 2013-04-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201210093293.3A CN103360450B (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610297739.2A Division CN105949264A (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法

Publications (2)

Publication Number Publication Date
CN103360450A CN103360450A (zh) 2013-10-23
CN103360450B true CN103360450B (zh) 2016-05-11

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CN201210093293.3A Active CN103360450B (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法
CN201610297739.2A Pending CN105949264A (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610297739.2A Pending CN105949264A (zh) 2012-04-01 2012-04-01 人参皂苷c-k的两种晶型及其制备方法

Country Status (6)

Country Link
US (1) US9643992B2 (https=)
EP (1) EP2835377B1 (https=)
JP (1) JP2015511608A (https=)
CN (2) CN103360450B (https=)
IN (1) IN2014MN01941A (https=)
WO (1) WO2013149571A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3925966T3 (pl) * 2020-05-04 2025-03-31 Curacle Co., Ltd. Nowa krystaliczna postać związku blokującego przeciek naczyniowy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051919A2 (en) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
CN1167805C (zh) * 2001-11-06 2004-09-22 中国科学院大连化学物理研究所 用酶水解人参皂甙制备20－β-D-吡喃葡萄糖基原人参二醇
CN1184305C (zh) * 2002-06-20 2005-01-12 中国科学院大连化学物理研究所 一种黑曲霉及用其酵解人参皂甙制备稀有低极性人参皂甙的方法
CN100487131C (zh) * 2004-04-27 2009-05-13 复旦大学 一种制备人参皂甙Compound-K的方法
CN101139562B (zh) 2007-07-02 2010-06-09 昆明诺唯金参生物工程有限责任公司 一种链霉菌发酵三七皂苷制备稀有人参皂苷Compound K的方法
CN101921304B (zh) * 2009-06-17 2013-04-03 浙江海正药业股份有限公司 一种运用大孔树脂纯化人参皂甙compound-K的方法
CN102251009A (zh) * 2011-06-09 2011-11-23 华侨大学 一种稀有人参皂甙ih-901结晶的简易生产方法
CN103087138B (zh) * 2013-01-10 2015-06-24 天津大学 一种人参皂苷c-k一水合物晶体及制备方法

Also Published As

Publication number Publication date
EP2835377A1 (en) 2015-02-11
WO2013149571A1 (zh) 2013-10-10
CN105949264A (zh) 2016-09-21
EP2835377A4 (en) 2016-03-30
US20150057440A1 (en) 2015-02-26
US9643992B2 (en) 2017-05-09
CN103360450A (zh) 2013-10-23
IN2014MN01941A (https=) 2015-07-10
EP2835377B1 (en) 2018-12-05
JP2015511608A (ja) 2015-04-20

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