CN103328442A - 可用于治疗代谢性和炎性疾病的氮杂环丁烷衍生物 - Google Patents

可用于治疗代谢性和炎性疾病的氮杂环丁烷衍生物 Download PDF

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Publication number
CN103328442A
CN103328442A CN2012800059625A CN201280005962A CN103328442A CN 103328442 A CN103328442 A CN 103328442A CN 2012800059625 A CN2012800059625 A CN 2012800059625A CN 201280005962 A CN201280005962 A CN 201280005962A CN 103328442 A CN103328442 A CN 103328442A
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methyl
azetidine
compound
chloro
alkyl
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Chinese (zh)
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L·R·M·萨尼莱
M·R·皮佐内罗
N·特里巴鲁
N·E·R·旺德欣斯特
S·I·J·德沃斯
R·C·X·布莱斯
C·D·普尔拜克斯-勒布拉里
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Galapagos NV
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Galapagos NV
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2012800059625A 2011-01-19 2012-01-10 可用于治疗代谢性和炎性疾病的氮杂环丁烷衍生物 Pending CN103328442A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161434077P 2011-01-19 2011-01-19
US61/434,077 2011-01-19
PCT/EP2012/050297 WO2012098033A1 (en) 2011-01-19 2012-01-10 Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases

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CN103328442A true CN103328442A (zh) 2013-09-25

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US (2) US8759334B2 (https=)
EP (1) EP2665704A1 (https=)
JP (1) JP2014507414A (https=)
KR (1) KR20140040104A (https=)
CN (1) CN103328442A (https=)
AR (1) AR084857A1 (https=)
AU (1) AU2012208693B2 (https=)
BR (1) BR112013018286A2 (https=)
CA (1) CA2824460A1 (https=)
CO (1) CO6741223A2 (https=)
GB (1) GB2489382A (https=)
MX (1) MX2013008257A (https=)
PH (1) PH12013501437A1 (https=)
RU (1) RU2013138372A (https=)
SG (1) SG191291A1 (https=)
TW (1) TW201245144A (https=)
WO (1) WO2012098033A1 (https=)
ZA (1) ZA201304822B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107709337A (zh) * 2015-07-07 2018-02-16 日本烟草产业株式会社 7H‑吡咯并[2，3‑d]嘧啶衍生物的制备方法和其中间体
CN108863980A (zh) * 2018-07-05 2018-11-23 浙江工业大学 一种合成1-(5-苯并噻唑基)乙酮的方法
CN110684000A (zh) * 2019-10-18 2020-01-14 上海皓元医药股份有限公司 苯并呋喃衍生物的制备方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012208693B2 (en) * 2011-01-19 2015-02-26 Galapagos Nv Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
CN105916500A (zh) 2013-11-27 2016-08-31 欧洲筛选有限公司 用于治疗炎性疾病的化合物、药物组合物和方法
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
KR101656662B1 (ko) * 2014-11-18 2016-09-12 한국생명공학연구원 2-옥소-1,2,3,4-테트라하이드로피리미딘-5-카르복사미드 유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 조성물
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