CN103265489A - ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 - Google Patents
ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 Download PDFInfo
- Publication number
- CN103265489A CN103265489A CN2013102394747A CN201310239474A CN103265489A CN 103265489 A CN103265489 A CN 103265489A CN 2013102394747 A CN2013102394747 A CN 2013102394747A CN 201310239474 A CN201310239474 A CN 201310239474A CN 103265489 A CN103265489 A CN 103265489A
- Authority
- CN
- China
- Prior art keywords
- methyl
- preparation
- ent
- methoxyl group
- mutter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310239474.7A CN103265489B (zh) | 2013-06-17 | 2013-06-17 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310239474.7A CN103265489B (zh) | 2013-06-17 | 2013-06-17 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103265489A true CN103265489A (zh) | 2013-08-28 |
CN103265489B CN103265489B (zh) | 2015-03-25 |
Family
ID=49009166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310239474.7A Active CN103265489B (zh) | 2013-06-17 | 2013-06-17 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103265489B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104672141A (zh) * | 2013-11-29 | 2015-06-03 | 浙江普洛康裕制药有限公司 | 内-(14s)-3-甲氧基-17-甲基吗啡喃苦味酸盐及其制备方法和用途 |
CN104761496A (zh) * | 2015-04-02 | 2015-07-08 | 华东理工大学 | 一种右美沙芬中间体的合成方法 |
CN115784990A (zh) * | 2022-12-14 | 2023-03-14 | 江苏宝众宝达药业股份有限公司 | 一种右美沙芬非对映异构体的分离方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3919237A (en) * | 1972-07-07 | 1975-11-11 | Hoffmann La Roche | Preparation of isomorphinan derivative |
US4857648A (en) * | 1987-11-11 | 1989-08-15 | Hoffmann-La Roche Inc. | Isoquinoline derivatives |
CN1178790A (zh) * | 1996-10-02 | 1998-04-15 | 霍夫曼-拉罗奇有限公司 | 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 |
CN102241630A (zh) * | 2011-05-20 | 2011-11-16 | 杭州保灵集团有限公司 | 一种镇咳嗽药磷酸二甲啡烷的制备方法 |
CN102898372A (zh) * | 2012-10-23 | 2013-01-30 | 苏州立新制药有限公司 | 右美沙芬的制备方法 |
CN102977021A (zh) * | 2012-11-29 | 2013-03-20 | 威海迪之雅医药化工开发有限公司 | 一种氢溴酸右美沙芬的制备方法 |
-
2013
- 2013-06-17 CN CN201310239474.7A patent/CN103265489B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3919237A (en) * | 1972-07-07 | 1975-11-11 | Hoffmann La Roche | Preparation of isomorphinan derivative |
US4857648A (en) * | 1987-11-11 | 1989-08-15 | Hoffmann-La Roche Inc. | Isoquinoline derivatives |
CN1178790A (zh) * | 1996-10-02 | 1998-04-15 | 霍夫曼-拉罗奇有限公司 | 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 |
CN102241630A (zh) * | 2011-05-20 | 2011-11-16 | 杭州保灵集团有限公司 | 一种镇咳嗽药磷酸二甲啡烷的制备方法 |
CN102898372A (zh) * | 2012-10-23 | 2013-01-30 | 苏州立新制药有限公司 | 右美沙芬的制备方法 |
CN102977021A (zh) * | 2012-11-29 | 2013-03-20 | 威海迪之雅医药化工开发有限公司 | 一种氢溴酸右美沙芬的制备方法 |
Non-Patent Citations (1)
Title |
---|
田洪涛等: "右甲吗喃的合成工艺研究", 《今日药学》, vol. 18, no. 4, 15 August 2008 (2008-08-15), pages 63 - 64 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104672141A (zh) * | 2013-11-29 | 2015-06-03 | 浙江普洛康裕制药有限公司 | 内-(14s)-3-甲氧基-17-甲基吗啡喃苦味酸盐及其制备方法和用途 |
CN104672141B (zh) * | 2013-11-29 | 2017-02-15 | 浙江普洛康裕制药有限公司 | 内‑(14s)‑3‑甲氧基‑17‑甲基吗啡喃苦味酸盐及其制备方法和用途 |
CN104761496A (zh) * | 2015-04-02 | 2015-07-08 | 华东理工大学 | 一种右美沙芬中间体的合成方法 |
CN115784990A (zh) * | 2022-12-14 | 2023-03-14 | 江苏宝众宝达药业股份有限公司 | 一种右美沙芬非对映异构体的分离方法 |
CN115784990B (zh) * | 2022-12-14 | 2024-07-12 | 江苏宝众宝达药业股份有限公司 | 一种右美沙芬非对映异构体的分离方法 |
Also Published As
Publication number | Publication date |
---|---|
CN103265489B (zh) | 2015-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103626774A (zh) | 伊鲁替尼的制备方法 | |
CN106083717B (zh) | 一种氢溴酸右美沙芬中间体的拆分母液中副产物的消旋化回收方法 | |
CN104292145A (zh) | 一种6-溴吲哚衍生物的制备方法 | |
CN103265489A (zh) | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 | |
CN109438351B (zh) | 一种喷他佐辛中间体的制备方法 | |
CN104119273A (zh) | 一种制备右美沙芬的新方法 | |
CN117551094B (zh) | 一种高光学纯度罗通定的制备方法 | |
CN103408497A (zh) | 一种关于l-肌肽的制备方法 | |
CN103275005B (zh) | ent-3-甲氧基-17-甲基吗喃-10-酮的制备方法 | |
CN108218895B (zh) | 一锅法合成氯诺昔康中间体的方法 | |
CN103073494A (zh) | ent-3-甲氧基吗喃的制备方法 | |
CN102898372B (zh) | 右美沙芬的制备方法 | |
Nakajima et al. | Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain | |
CN103588750B (zh) | 替卡格雷中间体的制备方法 | |
CN104529911B (zh) | 一种氚标记艾地普林的制备方法 | |
CN107344944B (zh) | 一种制备地瑞那韦中间体的方法 | |
CN103073496B (zh) | 右美沙芬的制备方法 | |
CN103044327A (zh) | 一种右美沙芬的制备方法 | |
CN103113302A (zh) | 一种制备亚氨基芪的方法 | |
CN103601666A (zh) | 八氢环戊烷[c]吡咯的制备方法 | |
CN106279048A (zh) | 一种制备氯氮平关键中间体的方法 | |
CN102898415A (zh) | 雷替曲塞中间体n-(5-甲氨基-2-噻吩甲酰基)-l-谷氨酸二乙酯的制备方法 | |
IE55232B1 (en) | "n-(2-methoxyethyl)-noroxymorphone" | |
CN103073495B (zh) | 一种ent-3-甲氧基吗喃的制备方法 | |
CN102372707A (zh) | 6-甲基-4-溴-1,6-二氢吡咯[2,3-c]吡啶-7-酮的合成方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190308 Address after: 255000 Jinyang Road, Gaoqing Economic Development Zone, Zibo City, Shandong Province Patentee after: Shandong Lixin Pharmaceutical Co., Ltd. Address before: 215151 No. 21 Tangxi Road, Suzhou High-tech Zone, Jiangsu Province Patentee before: Suzhou Lixin Pharmacy Co., Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of ent-(14S)-3-methoxy-17-methylmolan Effective date of registration: 20190422 Granted publication date: 20150325 Pledgee: Hengfeng Bank Co., Ltd. Zibo Branch Pledgor: Shandong Lixin Pharmaceutical Co., Ltd. Registration number: 2019370000082 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20201111 Granted publication date: 20150325 Pledgee: Hengfeng Bank Co.,Ltd. Zibo Branch Pledgor: Shandong Lixin Pharmaceutical Co.,Ltd. Registration number: 2019370000082 |