CN1178790A - 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 - Google Patents
生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 Download PDFInfo
- Publication number
- CN1178790A CN1178790A CN97119635.4A CN97119635A CN1178790A CN 1178790 A CN1178790 A CN 1178790A CN 97119635 A CN97119635 A CN 97119635A CN 1178790 A CN1178790 A CN 1178790A
- Authority
- CN
- China
- Prior art keywords
- acid
- alpha
- alkylsulphonic acid
- octahydro
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
反应时间[h] | 温度[℃] | 转化率[%] |
0 | 10 | 0 |
24 | 12 | 25 |
48 | 14 | 55 |
72 | 17 | 78 |
96 | 20 | 89 |
120 | 21 | 98 |
144 | 21 | 99.5 |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96115783.1 | 1996-10-02 | ||
EP96115783 | 1996-10-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1178790A true CN1178790A (zh) | 1998-04-15 |
CN1102143C CN1102143C (zh) | 2003-02-26 |
Family
ID=8223254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97119635A Expired - Fee Related CN1102143C (zh) | 1996-10-02 | 1997-09-24 | 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5905153A (zh) |
JP (1) | JPH10114749A (zh) |
CN (1) | CN1102143C (zh) |
AT (1) | ATE257824T1 (zh) |
BR (1) | BR9704957A (zh) |
DE (1) | DE59711203D1 (zh) |
ID (1) | ID19595A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103044327A (zh) * | 2013-01-07 | 2013-04-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
CN103265489A (zh) * | 2013-06-17 | 2013-08-28 | 苏州立新制药有限公司 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
CN104761496B (zh) * | 2015-04-02 | 2017-05-24 | 华东理工大学 | 一种右美沙芬中间体的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH560194A5 (zh) * | 1967-08-25 | 1975-03-27 | Hoffmann La Roche | |
US3634429A (en) * | 1969-09-30 | 1972-01-11 | Hoffmann La Roche | Morphinan derivatives and preparation thereof |
US3914234A (en) * | 1972-03-10 | 1975-10-21 | Hoffmann La Roche | 2-Lower alkoxy-N-substituted-morphinan derivatives |
US3810899A (en) * | 1972-03-10 | 1974-05-14 | Hoffmann La Roche | 2-hydroxy-n-substituted-morphinan derivatives |
ZA73988B (en) * | 1972-03-10 | 1973-10-31 | Hoffmann La Roche | Morphinan derivatives |
US3914232A (en) * | 1972-10-20 | 1975-10-21 | Hoffmann La Roche | 2-And 4-acryloxy-N-substituted-morphinan derivatives |
US3914233A (en) * | 1972-10-20 | 1975-10-21 | Hoffmann La Roche | 4-Hydroxy-N-substituted morphinan derivatives |
DK168069B1 (da) * | 1987-11-11 | 1994-01-31 | Hoffmann La Roche | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
-
1997
- 1997-09-03 US US08/923,371 patent/US5905153A/en not_active Expired - Fee Related
- 1997-09-11 JP JP9246602A patent/JPH10114749A/ja active Pending
- 1997-09-12 ID IDP973173A patent/ID19595A/id unknown
- 1997-09-24 CN CN97119635A patent/CN1102143C/zh not_active Expired - Fee Related
- 1997-09-26 AT AT97116753T patent/ATE257824T1/de not_active IP Right Cessation
- 1997-09-26 DE DE59711203T patent/DE59711203D1/de not_active Expired - Fee Related
- 1997-10-01 BR BR9704957A patent/BR9704957A/pt not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103044327A (zh) * | 2013-01-07 | 2013-04-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
CN103044327B (zh) * | 2013-01-07 | 2014-12-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
CN103265489A (zh) * | 2013-06-17 | 2013-08-28 | 苏州立新制药有限公司 | ent-(14S)-3-甲氧基-17-甲基吗喃的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
BR9704957A (pt) | 1998-10-27 |
DE59711203D1 (de) | 2004-02-19 |
ATE257824T1 (de) | 2004-01-15 |
ID19595A (id) | 1998-07-23 |
JPH10114749A (ja) | 1998-05-06 |
US5905153A (en) | 1999-05-18 |
CN1102143C (zh) | 2003-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: DSM IP CAPITAL CO., LTD. Free format text: FORMER OWNER: HOFMANN LAROCHE CO., LTD. Effective date: 20040305 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20040305 Address after: Holland Heerlen Patentee after: D Sm IP asset company Address before: Basel Patentee before: Hoffmann La Roche |
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1059244 Country of ref document: HK |
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C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |