CN103044327A - 一种右美沙芬的制备方法 - Google Patents
一种右美沙芬的制备方法 Download PDFInfo
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- CN103044327A CN103044327A CN2013100042620A CN201310004262A CN103044327A CN 103044327 A CN103044327 A CN 103044327A CN 2013100042620 A CN2013100042620 A CN 2013100042620A CN 201310004262 A CN201310004262 A CN 201310004262A CN 103044327 A CN103044327 A CN 103044327A
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- benzyl
- methyl
- preparation
- dextromethorphane hbr
- reaction
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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CN201310004262.0A CN103044327B (zh) | 2013-01-07 | 2013-01-07 | 一种右美沙芬的制备方法 |
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CN201310004262.0A CN103044327B (zh) | 2013-01-07 | 2013-01-07 | 一种右美沙芬的制备方法 |
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CN103044327A true CN103044327A (zh) | 2013-04-17 |
CN103044327B CN103044327B (zh) | 2014-12-17 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103254131A (zh) * | 2013-04-23 | 2013-08-21 | 苏州谷力生物科技有限公司 | 一种右美沙芬原料药的精制工艺 |
CN104151192A (zh) * | 2014-05-07 | 2014-11-19 | 东力(南通)化工有限公司 | 一种米屈肼中间体3-(2,2,2-三甲基肼)丙酸甲酯甲基硫酸盐制备技术的改进方法 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1097006A (zh) * | 1993-01-06 | 1995-01-04 | 霍夫曼-拉罗奇有限公司 | O-芳基吗啡喃的醚类化合物 |
CN1178218A (zh) * | 1996-10-02 | 1998-04-08 | 霍夫曼-拉罗奇有限公司 | (z)-1-[1-(4-甲氧基亚苄基)-1,2,3,4,5,6,7,8-八氢-异喹啉-2-基]烷酮的生产方法 |
CN1178790A (zh) * | 1996-10-02 | 1998-04-15 | 霍夫曼-拉罗奇有限公司 | 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 |
US6670370B1 (en) * | 2001-12-14 | 2003-12-30 | Jame Fine Chemicals, Inc. | Dextromethorphan tannate |
CN101687868A (zh) * | 2007-05-01 | 2010-03-31 | 康塞特医药品公司 | 吗啡烷化合物 |
WO2010062690A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
WO2010062692A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
WO2011032214A1 (en) * | 2009-09-16 | 2011-03-24 | Monash University | A method for the n-demethylation of n-methyl heterocycles |
CN102197037A (zh) * | 2008-09-19 | 2011-09-21 | 康塞特医药品公司 | 吗啡喃(morphinan)化合物 |
CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
-
2013
- 2013-01-07 CN CN201310004262.0A patent/CN103044327B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1097006A (zh) * | 1993-01-06 | 1995-01-04 | 霍夫曼-拉罗奇有限公司 | O-芳基吗啡喃的醚类化合物 |
CN1178218A (zh) * | 1996-10-02 | 1998-04-08 | 霍夫曼-拉罗奇有限公司 | (z)-1-[1-(4-甲氧基亚苄基)-1,2,3,4,5,6,7,8-八氢-异喹啉-2-基]烷酮的生产方法 |
CN1178790A (zh) * | 1996-10-02 | 1998-04-15 | 霍夫曼-拉罗奇有限公司 | 生产(9α,13α,14α)-1-(3-甲氧基吗啡喃-17-基)烷酮的方法 |
US6670370B1 (en) * | 2001-12-14 | 2003-12-30 | Jame Fine Chemicals, Inc. | Dextromethorphan tannate |
CN101687868A (zh) * | 2007-05-01 | 2010-03-31 | 康塞特医药品公司 | 吗啡烷化合物 |
CN102197037A (zh) * | 2008-09-19 | 2011-09-21 | 康塞特医药品公司 | 吗啡喃(morphinan)化合物 |
WO2010062690A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
WO2010062692A1 (en) * | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
WO2011032214A1 (en) * | 2009-09-16 | 2011-03-24 | Monash University | A method for the n-demethylation of n-methyl heterocycles |
Non-Patent Citations (5)
Title |
---|
《Journal of Organic Chemistry》 19650630 WILLIAM H. PIRKLE,等 The Derivation of Hydroaromatic Morphinans and Isomorphinans from Natural Sources 第1769-1773页 1-10 第30卷, 第6期 * |
GAIK B. KOK,等: "N-Demethylation of N-methyl alkaloids with ferrocene", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
GAIK KOK,等: "An Improved Process for the N-Demethylation of Opiate Alkaloids using an Iron(II) Catalyst in Acetate Buffer", 《ADVANCED SYNTHESIS & CATALYSIS》 * |
WILLIAM H. PIRKLE,等: "The Derivation of Hydroaromatic Morphinans and Isomorphinans from Natural Sources", 《JOURNAL OF ORGANIC CHEMISTRY》 * |
田洪涛,等: "右甲吗喃的合成工艺研究", 《今日药学》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103254131A (zh) * | 2013-04-23 | 2013-08-21 | 苏州谷力生物科技有限公司 | 一种右美沙芬原料药的精制工艺 |
CN104151192A (zh) * | 2014-05-07 | 2014-11-19 | 东力(南通)化工有限公司 | 一种米屈肼中间体3-(2,2,2-三甲基肼)丙酸甲酯甲基硫酸盐制备技术的改进方法 |
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Denomination of invention: Preparation method of dextromethorphan Effective date of registration: 20190422 Granted publication date: 20141217 Pledgee: Hengfeng Bank Co., Ltd. Zibo Branch Pledgor: Suzhou Lixin Pharmacy Co., Ltd. Registration number: 2019370000083 |
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Date of cancellation: 20201124 Granted publication date: 20141217 Pledgee: Hengfeng Bank Co.,Ltd. Zibo Branch Pledgor: SUZHOU LIXIN PHARMACEUTICAL Co.,Ltd. Registration number: 2019370000083 |