CN103159680A - 咪唑二酮类化合物及其用途 - Google Patents

咪唑二酮类化合物及其用途 Download PDF

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Publication number
CN103159680A
CN103159680A CN2011104188590A CN201110418859A CN103159680A CN 103159680 A CN103159680 A CN 103159680A CN 2011104188590 A CN2011104188590 A CN 2011104188590A CN 201110418859 A CN201110418859 A CN 201110418859A CN 103159680 A CN103159680 A CN 103159680A
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CN
China
Prior art keywords
compound
deuterium
generation
methyl
hydrogen
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Pending
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CN2011104188590A
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English (en)
Chinese (zh)
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMYNIDY PHARMACEUTICAL Co Ltd
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AMYNIDY PHARMACEUTICAL Co Ltd
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Application filed by AMYNIDY PHARMACEUTICAL Co Ltd filed Critical AMYNIDY PHARMACEUTICAL Co Ltd
Priority to CN2011104188590A priority Critical patent/CN103159680A/zh
Priority to ES12858174.1T priority patent/ES2587903T3/es
Priority to EP12858174.1A priority patent/EP2792674B1/en
Priority to JP2014546301A priority patent/JP5933746B2/ja
Priority to US14/364,147 priority patent/US9346764B2/en
Priority to PCT/CN2012/086573 priority patent/WO2013087004A1/zh
Priority to PL12858174.1T priority patent/PL2792674T3/pl
Priority to CN201280052853.9A priority patent/CN104024228B/zh
Priority to CA2859224A priority patent/CA2859224C/en
Priority to HK14111671.7A priority patent/HK1198166B/en
Priority to AU2012350482A priority patent/AU2012350482B2/en
Publication of CN103159680A publication Critical patent/CN103159680A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011104188590A 2011-12-14 2011-12-14 咪唑二酮类化合物及其用途 Pending CN103159680A (zh)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN2011104188590A CN103159680A (zh) 2011-12-14 2011-12-14 咪唑二酮类化合物及其用途
ES12858174.1T ES2587903T3 (es) 2011-12-14 2012-12-13 Compuestos de imidazolidinadiona y sus usos
EP12858174.1A EP2792674B1 (en) 2011-12-14 2012-12-13 Imidazolidinedione compounds and their uses
JP2014546301A JP5933746B2 (ja) 2011-12-14 2012-12-13 イミダゾリジンジオン系化合物およびその用途
US14/364,147 US9346764B2 (en) 2011-12-14 2012-12-13 Imidazolidinedione compounds and their uses
PCT/CN2012/086573 WO2013087004A1 (zh) 2011-12-14 2012-12-13 咪唑二酮类化合物及其用途
PL12858174.1T PL2792674T3 (pl) 2011-12-14 2012-12-13 Związki imidazolidynodionu i ich zastosowania
CN201280052853.9A CN104024228B (zh) 2011-12-14 2012-12-13 咪唑二酮类化合物及其用途
CA2859224A CA2859224C (en) 2011-12-14 2012-12-13 Imidazolidinedione compounds and their uses
HK14111671.7A HK1198166B (en) 2011-12-14 2012-12-13 Imidazolidinedione compounds and their uses
AU2012350482A AU2012350482B2 (en) 2011-12-14 2012-12-13 Imidazolidinedione compounds and their uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011104188590A CN103159680A (zh) 2011-12-14 2011-12-14 咪唑二酮类化合物及其用途

Publications (1)

Publication Number Publication Date
CN103159680A true CN103159680A (zh) 2013-06-19

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CN2011104188590A Pending CN103159680A (zh) 2011-12-14 2011-12-14 咪唑二酮类化合物及其用途
CN201280052853.9A Active CN104024228B (zh) 2011-12-14 2012-12-13 咪唑二酮类化合物及其用途

Family Applications After (1)

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Country Status (9)

Country Link
US (1) US9346764B2 (https=)
EP (1) EP2792674B1 (https=)
JP (1) JP5933746B2 (https=)
CN (2) CN103159680A (https=)
AU (1) AU2012350482B2 (https=)
CA (1) CA2859224C (https=)
ES (1) ES2587903T3 (https=)
PL (1) PL2792674T3 (https=)
WO (1) WO2013087004A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104803919A (zh) * 2014-01-26 2015-07-29 上海医药工业研究院 用于制备恩杂鲁胺中间体的方法
CN106432090A (zh) * 2015-10-30 2017-02-22 成都海创药业有限公司 一种氘代咪唑酮化合物的晶型及其制备方法和用途
CN106543085A (zh) * 2013-10-14 2017-03-29 杭州普晒医药科技有限公司 恩杂鲁胺的固态形式及其制备方法和用途
WO2018072300A1 (zh) * 2016-10-17 2018-04-26 成都海创药业有限公司 一种制备氘代咪唑二酮类化合物的方法
WO2019196945A1 (zh) * 2018-04-13 2019-10-17 成都海创药业有限公司 一种合成氘代酰胺及氘代磺酰胺的新方法
WO2021037198A1 (zh) * 2019-08-30 2021-03-04 润佳（苏州）医药科技有限公司 氘代化合物及其在治疗癌症方面的应用
CN114181155A (zh) * 2021-12-21 2022-03-15 上海朝晖药业有限公司 碘-恩杂鲁胺及其制备方法及其应用
CN115181043A (zh) * 2022-07-27 2022-10-14 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6469092B2 (ja) * 2013-05-29 2019-02-13 ヒノバ ファーマシューティカルズ インコーポレイテッド イミダゾリジンジオン化合物及び薬物組成物
JP6346944B2 (ja) * 2013-09-19 2018-06-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 組み合わせ薬物療法
WO2016051423A2 (en) * 2014-10-01 2016-04-07 Laurus Labs Private Limited An improved process for the preparation of enzalutamide
CN107303278B (zh) * 2016-04-25 2020-11-13 成都海创药业有限公司 一种hc-1119固体分散体及其制备方法
CA3053805C (en) 2017-02-13 2020-06-30 Kangpu Biopharmaceuticals, Ltd. Combination treating prostate cancer, pharmaceutical composition and treatment method
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
CA3095221A1 (en) * 2018-03-29 2019-10-03 Hinova Pharmaceuticals Inc. Deuterated imidazolidinedione compounds and their uses
KR102542275B1 (ko) * 2018-05-14 2023-06-12 하이노바 파마슈티컬스 인코포레이티드 Hc-1119 제제 및 그 제조방법 및 용도
US20210386826A1 (en) 2018-11-05 2021-12-16 Pfizer Inc. Combination for Treating Cancer
EP4122925A4 (en) * 2020-03-17 2024-04-17 Medshine Discovery Inc. Proteolysis regulator and method for using same
AU2021325426A1 (en) 2020-08-13 2023-03-09 Astellas Pharma Inc. Combination therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ564223A (en) * 2005-05-13 2011-03-31 Univ California Diarylhydantoin compounds for treating hormone refractory prostate cancer
SI2656842T1 (sl) 2006-03-27 2016-10-28 The Regents Of The University Of California Modulator androgenih receptorjev za zdravljenje raka prostate in bolezni, povezanih z androgenimi receptorji
WO2007127010A2 (en) * 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
CN101817787B (zh) 2009-02-26 2013-07-24 童友之 抗前列腺癌的雄性激素受体拮抗剂
US8809550B2 (en) 2009-09-10 2014-08-19 Youzhi Tong Androgen receptor antagonists and uses thereof
WO2013067151A1 (en) * 2011-11-02 2013-05-10 Medivation Prostate Therapeutics, Inc. Treatment methods using diarylthiohydantoin derivatives

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106543085A (zh) * 2013-10-14 2017-03-29 杭州普晒医药科技有限公司 恩杂鲁胺的固态形式及其制备方法和用途
CN104803919A (zh) * 2014-01-26 2015-07-29 上海医药工业研究院 用于制备恩杂鲁胺中间体的方法
CN106432090A (zh) * 2015-10-30 2017-02-22 成都海创药业有限公司 一种氘代咪唑酮化合物的晶型及其制备方法和用途
CN106432090B (zh) * 2015-10-30 2019-08-20 成都海创药业有限公司 一种氘代咪唑酮化合物的晶型及其制备方法和用途
WO2018072300A1 (zh) * 2016-10-17 2018-04-26 成都海创药业有限公司 一种制备氘代咪唑二酮类化合物的方法
WO2019196945A1 (zh) * 2018-04-13 2019-10-17 成都海创药业有限公司 一种合成氘代酰胺及氘代磺酰胺的新方法
CN110372598A (zh) * 2018-04-13 2019-10-25 成都海创药业有限公司 一种合成氘代酰胺及氘代磺酰胺的新方法
US11753392B2 (en) 2018-04-13 2023-09-12 Hinova Pharmaceuticals Inc. Method for synthesis of deuterated amide and deuterated sulfonamide
WO2021037198A1 (zh) * 2019-08-30 2021-03-04 润佳（苏州）医药科技有限公司 氘代化合物及其在治疗癌症方面的应用
CN114181155A (zh) * 2021-12-21 2022-03-15 上海朝晖药业有限公司 碘-恩杂鲁胺及其制备方法及其应用
CN115181043A (zh) * 2022-07-27 2022-10-14 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法
CN115181043B (zh) * 2022-07-27 2024-05-07 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法

Also Published As

Publication number Publication date
EP2792674B1 (en) 2016-05-25
PL2792674T3 (pl) 2016-12-30
US20140371284A1 (en) 2014-12-18
ES2587903T3 (es) 2016-10-27
CA2859224A1 (en) 2013-06-20
CN104024228B (zh) 2015-07-08
HK1198166A1 (en) 2015-03-13
EP2792674A4 (en) 2015-06-17
EP2792674A1 (en) 2014-10-22
US9346764B2 (en) 2016-05-24
AU2012350482A1 (en) 2014-07-10
AU2012350482B2 (en) 2017-02-16
CA2859224C (en) 2019-03-19
JP5933746B2 (ja) 2016-06-15
WO2013087004A1 (zh) 2013-06-20
JP2015501820A (ja) 2015-01-19
CN104024228A (zh) 2014-09-03

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Application publication date: 20130619