CN103130876A - 一种高纯度多粘菌素b的制备方法 - Google Patents
一种高纯度多粘菌素b的制备方法 Download PDFInfo
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- CN103130876A CN103130876A CN2011103906245A CN201110390624A CN103130876A CN 103130876 A CN103130876 A CN 103130876A CN 2011103906245 A CN2011103906245 A CN 2011103906245A CN 201110390624 A CN201110390624 A CN 201110390624A CN 103130876 A CN103130876 A CN 103130876A
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- polymyxin
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多粘菌素 | R | R′ | X | 分子式 | Mr |
B1 | CH3 | CH3 | L-Leu | C56H98N16O13 | 1204 |
B2 | H | CH3 | L-Leu | C56H96N16O13 | 1190 |
B3 | CH3 | H | L-Leu | C56H96N16O13 | 1190 |
B1-I | CH3 | CH3 | L-Ile | C56H98N16O13 | 1204 |
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CN201110390624.5A CN103130876B (zh) | 2011-11-30 | 2011-11-30 | 一种高纯度多粘菌素b的制备方法 |
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CN201110390624.5A CN103130876B (zh) | 2011-11-30 | 2011-11-30 | 一种高纯度多粘菌素b的制备方法 |
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CN103130876A true CN103130876A (zh) | 2013-06-05 |
CN103130876B CN103130876B (zh) | 2014-07-23 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102863518A (zh) * | 2012-10-09 | 2013-01-09 | 湖北美林药业有限公司 | 一种多粘菌素b化合物及其制备方法 |
WO2016100578A2 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
CN106868079A (zh) * | 2017-04-26 | 2017-06-20 | 山东鲁抗医药股份有限公司 | 发酵硫酸多粘菌素b用培养基及发酵生产硫酸多粘菌素b的方法 |
CN107367562A (zh) * | 2017-08-03 | 2017-11-21 | 上海上药第生化药业有限公司 | 硫酸多黏菌素b的分析检测方法及应用 |
WO2018032505A1 (zh) * | 2016-08-19 | 2018-02-22 | 湖北瑞昊安科医药科技发展有限公司 | 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法 |
CN107759670A (zh) * | 2016-08-19 | 2018-03-06 | 湖北瑞昊安科医药科技发展有限公司 | 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法 |
CN111410682A (zh) * | 2020-04-28 | 2020-07-14 | 梯尔希(南京)药物研发有限公司 | 多粘菌素b相关化合物的环化制备方法 |
WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
CN116284254A (zh) * | 2023-02-28 | 2023-06-23 | 黄石曼菲特生物科技有限公司 | 一种从发酵液中提取高纯度高含量硫酸多粘菌素b单组分的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010058427A2 (en) * | 2008-11-24 | 2010-05-27 | Reliance Life Sciences Pvt. Ltd. | Process for production and purification of polymyxin b sulfate |
CN101974075A (zh) * | 2010-10-12 | 2011-02-16 | 山东鲁抗医药股份有限公司 | 从发酵技术培养物中提取多粘菌素b、e的方法 |
-
2011
- 2011-11-30 CN CN201110390624.5A patent/CN103130876B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010058427A2 (en) * | 2008-11-24 | 2010-05-27 | Reliance Life Sciences Pvt. Ltd. | Process for production and purification of polymyxin b sulfate |
WO2010058427A3 (en) * | 2008-11-24 | 2010-09-10 | Reliance Life Sciences Pvt. Ltd. | Process for production and purification of polymyxin b sulfate |
CN101974075A (zh) * | 2010-10-12 | 2011-02-16 | 山东鲁抗医药股份有限公司 | 从发酵技术培养物中提取多粘菌素b、e的方法 |
Non-Patent Citations (2)
Title |
---|
何凤云等: "多粘菌素B中多粘菌素B_1的制备方法研究", 《化工时刊》 * |
田东 等: "响应面法优化多粘菌素B的发酵条件", 《中国农学通报》 * |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102863518B (zh) * | 2012-10-09 | 2014-04-30 | 湖北美林药业有限公司 | 一种多粘菌素b化合物及其制备方法 |
CN102863518A (zh) * | 2012-10-09 | 2013-01-09 | 湖北美林药业有限公司 | 一种多粘菌素b化合物及其制备方法 |
US9771394B2 (en) | 2014-12-16 | 2017-09-26 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
WO2016100578A2 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
CN107759670B (zh) * | 2016-08-19 | 2020-12-04 | 湖北瑞昊安科医药科技发展有限公司 | 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法 |
WO2018032505A1 (zh) * | 2016-08-19 | 2018-02-22 | 湖北瑞昊安科医药科技发展有限公司 | 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法 |
CN107759670A (zh) * | 2016-08-19 | 2018-03-06 | 湖北瑞昊安科医药科技发展有限公司 | 硫酸多粘菌素b1、b2或其混合物的结晶及其制备方法 |
CN106868079A (zh) * | 2017-04-26 | 2017-06-20 | 山东鲁抗医药股份有限公司 | 发酵硫酸多粘菌素b用培养基及发酵生产硫酸多粘菌素b的方法 |
CN106868079B (zh) * | 2017-04-26 | 2020-12-08 | 山东鲁抗医药股份有限公司 | 发酵硫酸多粘菌素b用培养基及发酵生产硫酸多粘菌素b的方法 |
CN107367562A (zh) * | 2017-08-03 | 2017-11-21 | 上海上药第生化药业有限公司 | 硫酸多黏菌素b的分析检测方法及应用 |
WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
CN111410682A (zh) * | 2020-04-28 | 2020-07-14 | 梯尔希(南京)药物研发有限公司 | 多粘菌素b相关化合物的环化制备方法 |
CN116284254A (zh) * | 2023-02-28 | 2023-06-23 | 黄石曼菲特生物科技有限公司 | 一种从发酵液中提取高纯度高含量硫酸多粘菌素b单组分的方法 |
CN116284254B (zh) * | 2023-02-28 | 2023-08-04 | 黄石曼菲特生物科技有限公司 | 一种从发酵液中提取高纯度高含量硫酸多粘菌素b单组分的方法 |
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