CN103025730A - 制备利奈唑胺的方法 - Google Patents

制备利奈唑胺的方法 Download PDF

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Publication number
CN103025730A
CN103025730A CN2011800328913A CN201180032891A CN103025730A CN 103025730 A CN103025730 A CN 103025730A CN 2011800328913 A CN2011800328913 A CN 2011800328913A CN 201180032891 A CN201180032891 A CN 201180032891A CN 103025730 A CN103025730 A CN 103025730A
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CN
China
Prior art keywords
fluoro
salt
described method
compound
amino
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Pending
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CN2011800328913A
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English (en)
Chinese (zh)
Inventor
J.R.麦克卡菲
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of CN103025730A publication Critical patent/CN103025730A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2011800328913A 2010-04-30 2011-04-28 制备利奈唑胺的方法 Pending CN103025730A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US32989210P 2010-04-30 2010-04-30
US61/329892 2010-04-30
US35985110P 2010-06-30 2010-06-30
US61/359851 2010-06-30
US37557610P 2010-08-20 2010-08-20
US61/375576 2010-08-20
US38953410P 2010-10-04 2010-10-04
US61/389534 2010-10-04
US42144210P 2010-12-09 2010-12-09
US61/421442 2010-12-09
PCT/US2011/034278 WO2011137222A1 (en) 2010-04-30 2011-04-28 Processes for preparing linezolid

Publications (1)

Publication Number Publication Date
CN103025730A true CN103025730A (zh) 2013-04-03

Family

ID=44861911

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800328913A Pending CN103025730A (zh) 2010-04-30 2011-04-28 制备利奈唑胺的方法

Country Status (15)

Country Link
US (2) US9206141B2 (https=)
EP (2) EP2563781B1 (https=)
JP (1) JP5865898B2 (https=)
KR (1) KR20130108975A (https=)
CN (1) CN103025730A (https=)
AU (1) AU2011245302A1 (https=)
BR (1) BR112012027901A2 (https=)
CA (1) CA2798101A1 (https=)
IL (1) IL222770A0 (https=)
MX (1) MX2012012627A (https=)
RU (1) RU2012151303A (https=)
SG (1) SG185103A1 (https=)
TW (1) TWI535715B (https=)
WO (1) WO2011137222A1 (https=)
ZA (1) ZA201208382B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110194750A (zh) * 2019-06-19 2019-09-03 四川美大康华康药业有限公司 一种利奈唑胺的制备方法及精制方法
CN112159368A (zh) * 2020-07-07 2021-01-01 杭州杜易科技有限公司 一种利奈唑胺中间体的合成方法
CN115684399A (zh) * 2022-10-27 2023-02-03 贵州健安德科技有限公司 一种氯醇亚胺的高效液相检测及含量测定方法

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* Cited by examiner, † Cited by third party
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JP5865898B2 (ja) * 2010-04-30 2016-02-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ リネゾリドを調製するためのプロセス
CN106279054A (zh) 2011-02-24 2017-01-04 李药业有限公司 利奈唑胺及其新中间体的新制备方法
WO2013072923A1 (en) * 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
CN103254148B (zh) 2012-02-15 2016-04-13 浙江海正药业股份有限公司 利奈唑胺中间体的制备方法
CN103288814B (zh) * 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法
US9562040B2 (en) 2012-04-06 2017-02-07 Indiana University Research And Technology Corporation Processes for preparing Rivaroxaban
ITMI20120655A1 (it) * 2012-04-19 2013-10-20 Bioindustria Lab Italiano M Edicinali Spa Procedimento per la preparazione di linezolid
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
CN103626712B (zh) * 2012-08-23 2016-06-01 重庆药友制药有限责任公司 一种用于制备利奈唑胺的中间体及其制备方法
WO2014045292A1 (en) * 2012-09-20 2014-03-27 Symed Labs Limited Improved process for the preparation of linezolid intermediate
WO2014170908A1 (en) * 2013-04-18 2014-10-23 Nosch Labs Private Limited Process for preparation of oxazolidinone derivatives
EP3250568A4 (en) * 2016-04-21 2018-08-01 Optimus Drugs Pvt Ltd An improved process for the preparation of linezolid
RU2760198C1 (ru) * 2020-12-16 2021-11-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Однореакторный способ получения полупродукта для синтеза линезолида

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US3725450A (en) * 1970-10-05 1973-04-03 Gen Mills Chem Inc Process for the preparation of isocyanates from acyl azides
US5278179A (en) * 1991-06-14 1994-01-11 Bayer Aktiengesellschaft Pesticides based on substituted oxazolidinones, new substituted oxazolidinones, and their preparation and use
WO1995023797A1 (en) * 1994-03-04 1995-09-08 Merck & Co., Inc. Process for making an epoxide
US5756834A (en) * 1995-11-11 1998-05-26 Hoechst Aktiengesellschaft Process for preparing fluorinated aromatics
WO2007116284A1 (en) * 2006-04-07 2007-10-18 Pfizer Products Inc. Process for preparing linezolid
US20080045708A1 (en) * 2000-05-18 2008-02-21 Wei Tian New Process for the Synthesis of Morpholinylbenzenes
CN101638392A (zh) * 2009-08-24 2010-02-03 浙江工业大学 一种列奈唑酮的制备新方法

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US4937331A (en) 1988-03-25 1990-06-26 President And Fellows Of Harvard College Chiral azetidinone epoxides
DK1028940T3 (da) 1997-11-07 2007-07-30 Pharmacia & Upjohn Co Llc Fremgangsmåde til fremstilling af oxazolidinoner
US6921825B2 (en) 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
US6444813B2 (en) * 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
DE60118241T2 (de) 2000-10-17 2006-12-28 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur herstellung von oxazolidinonverbindungen
AU2002310156A1 (en) 2001-06-05 2002-12-16 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzo-fused cycloalkyl urea compounds
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CN101220001A (zh) 2008-01-25 2008-07-16 浙江博泰化工有限公司 一种利奈唑酮的合成方法
JP5865898B2 (ja) * 2010-04-30 2016-02-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ リネゾリドを調製するためのプロセス

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* Cited by examiner, † Cited by third party
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US3725450A (en) * 1970-10-05 1973-04-03 Gen Mills Chem Inc Process for the preparation of isocyanates from acyl azides
US5278179A (en) * 1991-06-14 1994-01-11 Bayer Aktiengesellschaft Pesticides based on substituted oxazolidinones, new substituted oxazolidinones, and their preparation and use
WO1995023797A1 (en) * 1994-03-04 1995-09-08 Merck & Co., Inc. Process for making an epoxide
US5756834A (en) * 1995-11-11 1998-05-26 Hoechst Aktiengesellschaft Process for preparing fluorinated aromatics
US20080045708A1 (en) * 2000-05-18 2008-02-21 Wei Tian New Process for the Synthesis of Morpholinylbenzenes
WO2007116284A1 (en) * 2006-04-07 2007-10-18 Pfizer Products Inc. Process for preparing linezolid
CN101638392A (zh) * 2009-08-24 2010-02-03 浙江工业大学 一种列奈唑酮的制备新方法

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XINGXIAN ZHANG, 等: "An efficient and practical synthesis of antibacterial linezolid", 《JOURNAL OF CHEMICAL RESEARCH》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110194750A (zh) * 2019-06-19 2019-09-03 四川美大康华康药业有限公司 一种利奈唑胺的制备方法及精制方法
CN112159368A (zh) * 2020-07-07 2021-01-01 杭州杜易科技有限公司 一种利奈唑胺中间体的合成方法
CN115684399A (zh) * 2022-10-27 2023-02-03 贵州健安德科技有限公司 一种氯醇亚胺的高效液相检测及含量测定方法
CN115684399B (zh) * 2022-10-27 2024-12-20 贵州健安德科技有限公司 一种氯醇亚胺的高效液相检测及含量测定方法

Also Published As

Publication number Publication date
EP2563781B1 (en) 2016-10-26
MX2012012627A (es) 2013-05-09
EP2563781A4 (en) 2013-11-06
US20160024032A1 (en) 2016-01-28
RU2012151303A (ru) 2014-06-10
ZA201208382B (en) 2015-06-24
TWI535715B (zh) 2016-06-01
EP2899185A1 (en) 2015-07-29
IL222770A0 (en) 2012-12-31
BR112012027901A2 (pt) 2015-09-08
EP2563781A1 (en) 2013-03-06
US9206141B2 (en) 2015-12-08
JP2013525454A (ja) 2013-06-20
EP2899185B1 (en) 2018-01-31
US20130053557A1 (en) 2013-02-28
JP5865898B2 (ja) 2016-02-17
CA2798101A1 (en) 2011-11-03
KR20130108975A (ko) 2013-10-07
WO2011137222A1 (en) 2011-11-03
US9656973B2 (en) 2017-05-23
TW201144301A (en) 2011-12-16
AU2011245302A1 (en) 2012-11-22
SG185103A1 (en) 2012-12-28

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Application publication date: 20130403