CN102939290B - 2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.5]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途 - Google Patents
2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.5]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途 Download PDFInfo
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- CN102939290B CN102939290B CN201180014627.7A CN201180014627A CN102939290B CN 102939290 B CN102939290 B CN 102939290B CN 201180014627 A CN201180014627 A CN 201180014627A CN 102939290 B CN102939290 B CN 102939290B
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- Prior art keywords
- dihydro
- diazaspiro
- inden
- nonane
- acetyl
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- 0 CC(C*C(CC1)C(NN2)=C1N=C2I)(CC1)CC*1C(C*)=O Chemical compound CC(C*C(CC1)C(NN2)=C1N=C2I)(CC1)CC*1C(C*)=O 0.000 description 2
- CESURFROKLKXQI-GOSISDBHSA-N C(C1(C2)CCNCC1)N2[C@H](CCc1c2)c1ccc2-c1ncccn1 Chemical compound C(C1(C2)CCNCC1)N2[C@H](CCc1c2)c1ccc2-c1ncccn1 CESURFROKLKXQI-GOSISDBHSA-N 0.000 description 1
- CKYFZKMPRIVFKW-UHFFFAOYSA-N CC1(C)OB(c(cc2CC3)ccc2C3=O)OC1(C)C Chemical compound CC1(C)OB(c(cc2CC3)ccc2C3=O)OC1(C)C CKYFZKMPRIVFKW-UHFFFAOYSA-N 0.000 description 1
- IUQZUQHAPZPOPD-JOCHJYFZSA-N COC(N1CCC(C2)(CN2[C@H](CCc2c3)c2ccc3-c(nc2)ccc2C#N)CC1)=O Chemical compound COC(N1CCC(C2)(CN2[C@H](CCc2c3)c2ccc3-c(nc2)ccc2C#N)CC1)=O IUQZUQHAPZPOPD-JOCHJYFZSA-N 0.000 description 1
- UHUCZYJVWVZKAH-AREMUKBSSA-N COc1ccc(CC(N2CCC(C3)(CN3[C@H](CCc3c4)c3ccc4-c3ncccn3)CC2)=O)cc1 Chemical compound COc1ccc(CC(N2CCC(C3)(CN3[C@H](CCc3c4)c3ccc4-c3ncccn3)CC2)=O)cc1 UHUCZYJVWVZKAH-AREMUKBSSA-N 0.000 description 1
- NATXGJPPVHDYCP-HHHXNRCGSA-N Cc1cc(-c2ccc([C@@H](CC3)N(C4)CC4(CC4)CCN4C(Cc(cc4)ncc4OC)=O)c3c2)ncn1 Chemical compound Cc1cc(-c2ccc([C@@H](CC3)N(C4)CC4(CC4)CCN4C(Cc(cc4)ncc4OC)=O)c3c2)ncn1 NATXGJPPVHDYCP-HHHXNRCGSA-N 0.000 description 1
- VHFDGOBPNBOUNA-HXUWFJFHSA-N Cc1nccc(-c2ccc([C@@H](CC3)N(C4)CC44CCNCC4)c3c2)n1 Chemical compound Cc1nccc(-c2ccc([C@@H](CC3)N(C4)CC44CCNCC4)c3c2)n1 VHFDGOBPNBOUNA-HXUWFJFHSA-N 0.000 description 1
- IEUKCNPRRGOGDG-SECBINFHSA-N N[C@H](CC1)c(cc2)c1cc2Br Chemical compound N[C@H](CC1)c(cc2)c1cc2Br IEUKCNPRRGOGDG-SECBINFHSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31552210P | 2010-03-19 | 2010-03-19 | |
| US61/315,522 | 2010-03-19 | ||
| US201161444401P | 2011-02-18 | 2011-02-18 | |
| US61/444,401 | 2011-02-18 | ||
| PCT/IB2011/051035 WO2011114271A1 (en) | 2010-03-19 | 2011-03-11 | 2,3 dihydro-1h-inden-1-yl- 2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102939290A CN102939290A (zh) | 2013-02-20 |
| CN102939290B true CN102939290B (zh) | 2015-09-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180014627.7A Expired - Fee Related CN102939290B (zh) | 2010-03-19 | 2011-03-11 | 2,3-二氢-1h-茚-1-基-2,7-二氮杂螺[3.5]壬烷衍生物及其作为生长激素释放肽受体的拮抗剂或反向激动剂的用途 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8609680B2 (https=) |
| EP (1) | EP2547679B1 (https=) |
| JP (1) | JP5496409B2 (https=) |
| KR (1) | KR101455917B1 (https=) |
| CN (1) | CN102939290B (https=) |
| AR (1) | AR080688A1 (https=) |
| AU (1) | AU2011228699B2 (https=) |
| BR (1) | BR112012023664B1 (https=) |
| CA (1) | CA2792234C (https=) |
| CY (1) | CY1118721T1 (https=) |
| DK (1) | DK2547679T3 (https=) |
| ES (1) | ES2557895T3 (https=) |
| HR (1) | HRP20151232T1 (https=) |
| HU (1) | HUE025774T2 (https=) |
| IL (1) | IL221952A (https=) |
| ME (1) | ME02330B (https=) |
| MX (1) | MX2012010772A (https=) |
| PH (1) | PH12012501800A1 (https=) |
| PL (1) | PL2547679T3 (https=) |
| PT (1) | PT2547679E (https=) |
| RS (1) | RS54383B1 (https=) |
| RU (1) | RU2524341C2 (https=) |
| SG (1) | SG183812A1 (https=) |
| SI (1) | SI2547679T1 (https=) |
| TW (1) | TWI410423B (https=) |
| WO (1) | WO2011114271A1 (https=) |
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| IN2014DN09346A (https=) | 2012-06-13 | 2015-07-17 | Hoffmann La Roche | |
| KR102179599B1 (ko) | 2012-09-25 | 2020-11-19 | 에프. 호프만-라 로슈 아게 | 이환형 유도체 |
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| CN105764905B (zh) | 2013-11-26 | 2019-06-07 | 豪夫迈·罗氏有限公司 | 新的八氢-环丁二烯并[1，2-c；3，4-c’]二吡咯-2基 |
| HUE038764T2 (hu) | 2014-03-17 | 2018-11-28 | Remynd Nv | 2,7-Diazaspiro[3.5]nonán vegyületek |
| WO2015144609A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| CN106103446B (zh) | 2014-03-26 | 2019-07-30 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
| CN106749002A (zh) * | 2015-02-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一种含硝基喹啉结构的葡萄糖激酶活化剂及其用途 |
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| KR20180054830A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
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| KR102882225B1 (ko) | 2017-02-21 | 2025-11-07 | 엘지전자 주식회사 | 냉장고 |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| SG11201908560SA (en) | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| AU2018306619B2 (en) | 2017-07-28 | 2022-06-02 | Chemocentryx, Inc. | Immunomodulator compounds |
| CN108588215A (zh) * | 2018-05-03 | 2018-09-28 | 成都中创清科医学检验所有限公司 | 一种用于检测家族性高胆固醇血症易感性相关的snp位点的引物及其检测方法 |
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| CN111777559B (zh) * | 2019-04-23 | 2021-11-09 | 苏州大学 | 基于端炔制备多取代吡唑的方法 |
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